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Adenosylmethionine hydrolase

From Wikipedia, the free encyclopedia
adenosylmethionine hydrolase
Identifiers
EC no.3.3.1.2
CAS no.37288-62-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, an adenosylmethionine hydrolase (EC 3.3.1.2) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + H2O L-homoserine + methylthioadenosine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and H2O, whereas its two products are L-homoserine and methylthioadenosine.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds involving sulfur (thioether and trialkylsulfonium hydrolases). The systematic name of this enzyme class is S-adenosyl-L-methionine hydrolase. Other names in common use include S-adenosylmethionine cleaving enzyme, methylmethionine-sulfonium-salt hydrolase, and adenosylmethionine lyase.

References

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  • Mazelis M, Levin B, Mallinson N (1965). "Decomposition of methyl methionine sulfonium salts by a bacterial enzyme". Biochim. Biophys. Acta. 105 (1): 106–14. doi:10.1016/s0926-6593(65)80179-5. PMID 5849106.