Cytoreductive surgery
Cytoreductive surgery (CRS) is a surgical procedure that aims to reduce the amount of cancer cells in the abdominal cavity for patients with tumors that have spread intraabdominally (peritoneal carcinomatosis). It is often used to treat ovarian cancer but can also be used for other abdominal malignancies.
CRS is often used in combination with hyperthermic intraperitoneal chemotherapy (HIPEC); for some cancer diagnoses it considerably increases life expectancy and reduces the rate of cancer recurrence.
Its main developer was Paul Sugarbaker, who is known for the development of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy,[1] or HIPEC, a treatment alternately referred to as the Sugarbaker Procedure.[2][3]
Ovarian cancer
[edit]Among patients with stage III epithelial ovarian cancer, the addition of HIPEC to interval cytoreductive surgery resulted in longer recurrence-free survival and overall survival than surgery alone and did not result in higher rates of side effects.[4]
Colorectal cancer
[edit]Among colorectal cancer patients with peritoneal carcinomatosis cytoreductive surgery, with the addition of HIPEC can be used to prolong overall survival in patients.[5] In a typical case an incision is made from the sternum down to the pelvis, and cancerous cells are removed. Then heated chemotherapy liquid is poured in to destroy remaining cells. The procedure, which may take 15 hours, is risky, and followed by prolonged recovery.[6]
References
[edit]- ^ Neuwirth, Madalyn G.; Alexander, H. Richard; Karakousis, Giorgos C. (February 2016). "Then and now: cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), a historical perspective". Journal of Gastrointestinal Oncology. 7 (1): 18–28. doi:10.3978/j.issn.2078-6891.2015.106. PMC 4754315. PMID 26941981.
- ^ Pollack, Andrew (12 August 2011). "Hot Chemotherapy Bath: Patients See Hope, Critics Hold Doubts". The New York Times.
- ^ Wilber, Del Quentin (2012-11-25). "Surgeon performs controversial cancer surgery named after him". Washington Post. Retrieved 2018-04-22.
- ^ van Driel, Willemien J.; Koole, Simone N.; Sikorska, Karolina; Schagen van Leeuwen, Jules H.; Schreuder, Henk W.R.; Hermans, Ralph H.M.; de Hingh, Ignace H.J.T.; van der Velden, Jacobus; Arts, Henriëtte J.; Massuger, Leon F.A.G.; Aalbers, Arend G.J.; Verwaal, Victor J.; Kieffer, Jacobien M.; Van de Vijver, Koen K.; van Tinteren, Harm; Aaronson, Neil K.; Sonke, Gabe S. (18 January 2018). "Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer". New England Journal of Medicine. 378 (3): 230–240. doi:10.1056/NEJMoa1708618. hdl:1874/364110. PMID 29342393.
- ^ Huang, Chao-Qun; Min, Yao; Wang, Shu-Yi; Yang, Xiao-Jun; Liu, Yang; Xiong, Bin; Yonemura, Yutaka; Li, Yan (15 August 2017). "Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival for peritoneal carcinomatosis from colorectal cancer: a systematic review and meta-analysis of current evidence". Oncotarget. 8 (33): 55657–55683. doi:10.18632/oncotarget.17497. PMC 5589691. PMID 28903452.
- ^ Harcombe, Chloe (16 June 2024). "Bowel cancer patient issues warning about silent killer". BBC News.