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Diazepam binding inhibitor

From Wikipedia, the free encyclopedia
DBI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDBI, ACBD1, ACBP, CCK-RP, EP, Diazepam binding inhibitor, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor, acyl-CoA binding protein
External IDsOMIM: 125950; MGI: 94865; HomoloGene: 39086; GeneCards: DBI; OMA:DBI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001037999
NM_007830

RefSeq (protein)

NP_001033088
NP_031856

Location (UCSC)Chr 2: 119.37 – 119.37 MbChr 1: 120.04 – 120.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.[5][6]

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155368Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026385Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Todd S, Naylor SL (Dec 1992). "New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene". Somat Cell Mol Genet. 18 (4): 381–385. doi:10.1007/BF01235761. PMID 1440058. S2CID 46694856.
  6. ^ a b "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)".

Further reading

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