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Interposed nucleus

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Interposed nucleus
Details
Identifiers
Latinnucleus interpositus anterior, nucleus interpositus posterior
NeuroLex IDnlx_anat_20081242
Anatomical terms of neuroanatomy

The interposed nucleus is the combined paired globose and emboliform nuclei, (deep cerebellar nuclei) on either side of the cerebellum.[1][2] It is located in the roof of the fourth ventricle, lateral to the fastigial nucleus. The emboliform nucleus is the anterior interposed nucleus, and the globose nucleus is the posterior interposed nucleus.[3]

The interposed nucleus is responsible for coordinating agonist/antagonist muscle pairs, and therefore a lesion in this area causes tremor.

Anatomy

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The interposed nucleus is located in the paravermis of the cerebellum.[citation needed]

The interposed nucleus is smaller than the dentate but larger than the fastigial nucleus.[citation needed]

Afferents

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The interposed nuclei receives Purkine cell terminal afferents from the paravermal cortex of the spinocerebellum, as well as collaterals of cerebellar afferents from the restiform body and ventral spinocerebellar tract.[2]

It receives input from the ipsilateral posterior external arcuate fibers (cuneocerebellar tract) and the dorsal spinocerebellar tract, which originate in the accessory cuneate nucleus and the posterior thoracic nucleus, respectively.[citation needed]

Efferents

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Afferents from the interposed nuclei leave the cerebellum through superior cerebellar peduncle. They project to:[2]

The rubrospinal and lateral corticospinal tracts are subsequently involved in control of the distal musculature of the extremities.

Function

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The interposed nucleus modulates muscle stretch reflexes of proximal limb muscles, and is also required in delayed Pavlovian conditioning.[4]

References

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  1. ^ Purves, Dale (2012). Neuroscience (5. ed.). Sunderland, Mass: Sinauer. p. 419. ISBN 9780878936953.
  2. ^ a b c Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 292. ISBN 978-1-118-67746-9.
  3. ^ Haines, Duane (2018). Fundamental neuroscience for basic and clinical applications (Fifth ed.). Philadelphia, PA: Elsevier. p. 396. ISBN 9780323396325.
  4. ^ Clark, Robert E.; Zhang, Andrew A.; Lavond, David G. (1992). "Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior". Behavioral Neuroscience. 106 (6): 879–888. doi:10.1037/0735-7044.106.6.879. PMID 1335267.
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