Sumatriptan/naproxen: Difference between revisions
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'''Sumatriptan/naproxen sodium''', sold under the brand name '''Treximet''', is a combination medication used to treat [[migraines]] attacks.<ref name=NIH2019/> It is taken |
'''Sumatriptan/naproxen sodium''', sold under the brand name '''Treximet''', is a combination medication used to treat [[migraines]] attacks.<ref name=NIH2019/> It is taken through oral route.<ref name=NIH2019>{{cite web |title=DailyMed - sumatriptan succinate and naproxen sodium tablet, film coated |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=67311f35-35cc-469d-a6eb-cf615af5403a |website=dailymed.nlm.nih.gov |accessdate=6 March 2019}}</ref> |
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==Active ingredients== |
==Active ingredients== |
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It combines 85 mg of [[sumatriptan]], a selective 5-hydroxytryptamine1 (5-HT1) receptor subtype agonist and 500 mg of [[naproxen sodium]], a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs), in one tablet. |
It combines 85 mg of [[sumatriptan]], a selective 5-hydroxytryptamine1 (5-HT1) receptor subtype agonist and 500 mg of [[naproxen sodium]], a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs), in one tablet. |
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==Medical use== |
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A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.<ref>{{cite journal |last1=Law |first1=Simon |last2=Derry |first2=Sheena |last3=Moore |first3=R Andrew |title=Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults |journal=Cochrane Database of Systematic Reviews |date=2016 |issue=4 |doi=10.1002/14651858.CD008541.pub3}}</ref> |
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==Side effects== |
==Side effects== |
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Revision as of 08:23, 28 February 2021
| Combination of | |
|---|---|
| Sumatriptan | Triptan |
| Naproxen sodium | NSAID |
| Clinical data | |
| Trade names | Treximet, Trexima, others |
| Routes of administration | By mouth |
| Identifiers | |
| KEGG | |
Sumatriptan/naproxen sodium, sold under the brand name Treximet, is a combination medication used to treat migraines attacks.[1] It is taken through oral route.[1]
Active ingredients
It combines 85 mg of sumatriptan, a selective 5-hydroxytryptamine1 (5-HT1) receptor subtype agonist and 500 mg of naproxen sodium, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs), in one tablet.
Medical use
A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.[2]
Side effects
Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.[3]
References
- ^ a b "DailyMed - sumatriptan succinate and naproxen sodium tablet, film coated". dailymed.nlm.nih.gov. Retrieved 6 March 2019.
- ^ Law, Simon; Derry, Sheena; Moore, R Andrew (2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". Cochrane Database of Systematic Reviews (4). doi:10.1002/14651858.CD008541.pub3.
- ^ https://www.drugs.com/treximet.html
External links
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