This article is about the 1964 Major League Baseball season only. For information on all
of baseball, see 1964 in baseball
The 1964 Major League Baseball season is best remembered for the end of the New York Yankees' dynasty, as they won their 29th American League Championship in 44 seasons. However, the Yankees lost the World Series to the St. Louis Cardinals in seven games. As of 2010, the Cardinals are the only National League team to have an edge over the Yankees in series played (3–2), amongst the non-expansion teams.
Regular season 
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Major league baseball final standings 
American League final standings 
National League final standings 
MLB statistical leaders 
American League 
National League 
- April 8 – Houston Colt .45s relief pitcher Jim Umbricht dies of cancer at the age of 33. The franchise would retire his number in 1965, by which time it is known as the Astros.
- June 21 – On Father's Day at Shea Stadium, Jim Bunning fans ten, drives in two runs, and pitches the first perfect game (excluding Don Larsen's 1956 World Series effort, and Harvey Haddix's 1959 extra-innings loss) since Charlie Robertson's on April 30, 1922, as the Philadelphia Phillies beat the New York Mets 6–0. Bunning also becomes the first pitcher to throw no-hitters in both leagues, and Gus Triandos becomes the first catcher to catch a no-hitter in each league. Bunning throws just 90 pitches in winning his second no-hitter. The next time Bunning faces the Mets he will shut them out, the first no-hit pitcher in the 20th century to do that. The Mets fare little better in the nightcap, as 18-year-old rookie Rick Wise pitches into the seventh inning to win his first game, giving up just three hits and three walks (Johnny Klippstein pitched the final three innings). The Phillies increase their National League lead to two games over the San Francisco Giants.
- August 12 – Mickey Mantle hits a home run from both sides of the plate in a 7–3 Yankees win over the Chicago White Sox. It is the tenth time in his career that he has done so and a major league record for switch-hit homers in a game.
- August 20 – At Comiskey Park, the Chicago White Sox complete a four-game sweep of the New York Yankees with a 5–0 shutout. As the Yankees' team bus heads to O'Hare International Airport after the game, pitcher Phil Linz takes out a harmonica and plays a plaintive version of "Mary Had a Little Lamb." Manager Yogi Berra tells Linz to put the harmonica away. When asked what Berra had said, Mickey Mantle tells Linz to "play it louder." Linz does so, prompting an unusually angry Berra to storm to the back to the bus and slap the harmonica out of Linz' hands; the instrument strikes Joe Pepitone's knee. The "Harmonica Incident" convinces the Yankee front office that Berra has lost control of the team and cannot command respect from his players. As a result, the decision is made to fire Berra at the end of the season.
- September 27 – Johnny Callison hits three home runs, but the Phillies lose to the Milwaukee Braves 14–8. The Phils suffer the seventh loss in their 10-game losing streak, while the Reds sweep the New York Mets (4–1 and 3–1). These results knock Philadelphia out of first place, with the Reds replacing them atop the NL standings. The Phillies would never return to first place in 1964.
- September 29 – The Pittsburgh Pirates blank the Reds 2–0 at Crosley Field (despite the Reds getting 11 hits off Bob Friend) to end the Reds' nine-game winning streak. Meanwhile, the St. Louis Cardinals defeat the Phillies 4–2 at Busch Stadium, the seventh win in the Cardinals' eight-game winning streak and the ninth loss in the Phillies' 10-game losing streak. The win, Ray Sadecki's 20th of the season, puts the Cardinals into a tie for first place with the Reds; St. Louis had been 11 games out of first on August 23.
- October 3 – As a result of the now-concluded Phillies' 10-game losing streak, this day begins with four teams still having a mathematical shot at the NL pennant. One of them, the San Francisco Giants, is eliminated with a 10–7 loss to the Chicago Cubs. At the end of the day's play, the Reds and the Cardinals are tied for first place, with the Phillies a game back. In recent days, the NL has had to scramble to schedule various possible playoffs.
- October 4 – The Phillies defeat the Reds, 10–0, in the last regular-season game for both teams unless there is a playoff; that result clinches (for the Cardinals) a tie for the NL pennant. At the end of that game, both teams are ½ game back of the Cardinals, and await the result of the Cardinals-Mets game. Then, the Cardinals, never in first place until the last week of the season, clinch their first pennant since 1946 with an 11–5 win over the Mets, who had just beaten the Cardinals twice in the two preceding days. The win by the Cardinals averts a three-way tie for the NL pennant, with the Phillies and the Reds both finishing one game back in a second-place tie.
- October 16 – The day after the final game of the World Series, the managerial posts of both pennant winning teams are vacant. In the morning, Johnny Keane, manager of the victorious St. Louis Cardinals, resigns, much to the surprise of owner Gussie Busch. Hours later, New York Yankee general manager Ralph Houk fires Yogi Berra as his manager, citing Berra's lack of control over team and his inability to command respect from his players. Less than a week later, Houk replaces Berra with Keane; meanwhile, Berra reunites with Casey Stengel as a coach with the New York Mets.
- December 1 – The Houston Colt .45s officially change their nickname to Astros. The change coincides with the team's impending move from Colt Stadium to the Harris County Domed Stadium, also known as the Astrodome. A change in name for the three-year old franchise is necessitated due to a dispute with the Colt firearm company; the Astros name is chosen due to Houston being the home of NASA's Manned Spacecraft Center (later the Lyndon B. Johnson Space Center).
- December 4:
- The Minnesota Twins acquire extremely versatile utility César Tovar from the Cincinnati Reds in exchange for pitcher Gerry Arrigo. Tovar will play eight seasons in Minnesota.
- MLB owners decide to use a free agent draft beginning in January 1965. The inverse order of the previous year's standings will be used to select players every four months.
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