ARHGAP5

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Rho GTPase activating protein 5
Protein ARHGAP5 PDB 2EE4.png
Rendering based on PDB 2EE4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGAP5 ; GFI2; RhoGAP5; p190-B; p190BRhoGAP
External IDs OMIM602680 MGI1332637 HomoloGene907 GeneCards: ARHGAP5 Gene
RNA expression pattern
PBB GE ARHGAP5 217936 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 394 11855
Ensembl ENSG00000100852 ENSMUSG00000035133
UniProt Q13017 E9PYT0
RefSeq (mRNA) NM_001030055 NM_009706
RefSeq (protein) NP_001025226 NP_033836
Location (UCSC) Chr 14:
32.55 – 32.63 Mb
Chr 12:
52.52 – 52.57 Mb
PubMed search [1] [2]

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.[1][2]

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions[edit]

ARHGAP5 has been shown to interact with Rnd1,[3] Rnd2,[3] Rnd3[3] and RHOA.[3]

References[edit]

  1. ^ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (Feb 1996). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J Biol Chem 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347. 
  2. ^ a b "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5". 
  3. ^ a b c d Wennerberg, Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 

Further reading[edit]