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Rho GTPase activating protein 5
Protein ARHGAP5 PDB 2EE4.png
Rendering based on PDB 2EE4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGAP5 ; GFI2; RhoGAP5; p190-B; p190BRhoGAP
External IDs OMIM602680 MGI1332637 HomoloGene907 GeneCards: ARHGAP5 Gene
RNA expression pattern
PBB GE ARHGAP5 217936 at tn.png
More reference expression data
Species Human Mouse
Entrez 394 11855
Ensembl ENSG00000100852 ENSMUSG00000035133
UniProt Q13017 E9PYT0
RefSeq (mRNA) NM_001030055 NM_009706
RefSeq (protein) NP_001025226 NP_033836
Location (UCSC) Chr 14:
32.55 – 32.63 Mb
Chr 12:
52.52 – 52.57 Mb
PubMed search [1] [2]

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.[1][2]

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.[2]


ARHGAP5 has been shown to interact with Rnd1,[3] Rnd2,[3] Rnd3[3] and RHOA.[3]


  1. ^ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (Feb 1996). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J Biol Chem 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347. 
  2. ^ a b "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5". 
  3. ^ a b c d Wennerberg, Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 

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