Tyrothricin

Tyrothricin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	D06AX08 (WHO) R02AB02 (WHO) S01AA05 (WHO);
Identifiers
CAS Number	1404-88-2 ;
PubChem CID	452550;
ChemSpider	398608;
UNII	877376V2XW;
KEGG	D06262 ;
ChEMBL	ChEMBL577736;
CompTox Dashboard (EPA)	DTXSID4045846 ;
ECHA InfoCard	100.014.337
	(verify)

Tyrothricin is an antibiotic mixture which was isolated from Brevibacillus brevis by Rene Dubos in the late 1930s. It was later shown by Dubos and Rollin Hotchkiss to be a mixture of two different antibiotics: gramicidin and tyrocidine.^[1]

Both gramicidin and tyrocidine are short polypeptides which disrupt the cell membranes of some, primarily Gram-positive, bacteria. Tyrothricin and its component antibiotics are too toxic to be taken internally but are sometimes used as topical antibiotics.

Tyrothricin, and its component antibiotics, belongs to the pharmacologically related group of polypeptide antibiotic compounds including colistin, polymyxin B, and bacitracin. There is no cross-resistance to these three agents.

References

^ Hotchkiss RD, Dubos RJ (December 1940). "Bactericidal fractions from an aerobic sporulating bacillus" (PDF). Journal of Biological Chemistry. 136 (3): 803–804. doi:10.1016/S0021-9258(18)73041-X.

[1] Hotchkiss RD, Dubos RJ (December 1940). "Bactericidal fractions from an aerobic sporulating bacillus" (PDF). Journal of Biological Chemistry. 136 (3): 803–804. doi:10.1016/S0021-9258(18)73041-X.

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