Earth's second-largest annual animal migration (largest is the Serengeti migration), involving multiple species of antelope including reedbuck, tiang, and white-eared kob, takes place in the park, which is also home to iconic Africanmegafauna like the giraffe. It also contains large marshlands stretching up into Jonglei state. The park supports large bird populations. Though a major wildlife preserve, the park lies within a Total oil concession, potentially exposing it to surveying and drilling.
On 6 July 2011, three days before South Sudan formally seceded from Sudan, an administrative headquarters was officially opened at a ribbon-cutting ceremony led by Central Equatoria Governor Clement Wani and USAID's Sudan director William Hammink. Due to South Sudan's intense poverty and a lack of facilities, something the new administrative center is part of plans to alleviate, Bandingilo is one of the least touristed national parks in the world.