Carnosine synthase

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Enzyme[edit]

carnosine synthase
Identifiers
EC number 6.3.2.11
CAS number 9023-61-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a carnosine synthase (EC 6.3.2.11) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + beta-alanine \rightleftharpoons AMP + diphosphate + carnosine

The 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are AMP, diphosphate, and carnosine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is 'L-histidine:beta-alanine ligase (AMP-forming)'. Other names in common use include 'carnosine synthetase', 'carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'.

Gene[edit]

The gene encoding this enzyme has been identified by Jakub Drozak an coworkers in 2010.[1] The gene encoding the Carnosine synthase is ATPGD1, a member of the “ATP-grasp family” of ligases. Because of its involvement in the formation of carnosine, this gene is now also named 'CARNS1'.[2]

References[edit]

  1. ^ "Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).". PMID 20097752. 
  2. ^ http://www.genecards.org/cgi-bin/carddisp.pl?gene=CARNS1&search=abda0915c56ce01e508b3112e800e57e.  Missing or empty |title= (help);