Cathepsin A

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Cathepsin A
Protein CTSA PDB 1ivy.png
PDB rendering based on 1ivy.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM613111 MGI97748 HomoloGene80163 IUPHAR: 1581 ChEMBL: 6115 GeneCards: CTSA Gene
EC number
RNA expression pattern
PBB GE CTSA 200661 at tn.png
More reference expression data
Species Human Mouse
Entrez 5476 19025
Ensembl ENSG00000064601 ENSMUSG00000017760
UniProt P10619 P16675
RefSeq (mRNA) NM_000308 NM_001038492
RefSeq (protein) NP_000299 NP_001033581
Location (UCSC) Chr 20:
44.52 – 44.53 Mb
Chr 2:
164.83 – 164.84 Mb
PubMed search [1] [2]

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.[1]


This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.[2]

Clinical significance[edit]

Deficiencies in this gene are linked to multiple forms of galactosialidosis.[1]


Cathepsin A has been shown to interact with NEU1.[3]


  1. ^ a b "Entrez Gene: CTSA cathepsin A". 
  2. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Robbins, Stanley L.; Abbas, Abul K.; Fausto, Nelson (2007). "Table 7-6". Robbins basic pathology (8th ed.). Saunders/Elsevier. ISBN 1-4160-2973-7. 
  3. ^ van der Spoel, A; Bonten E; d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A". EMBO J. (ENGLAND) 17 (6): 1588–97. doi:10.1093/emboj/17.6.1588. ISSN 0261-4189. PMC 1170506. PMID 9501080. 

Further reading[edit]

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