Cranberry

From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about a group of plant species. For the rock band, see The Cranberries. For other uses, see Cranberry (disambiguation).
Cranberry
Cranberry bog.jpg
Cranberry bush with fruit partially submerged
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Asterids
Order: Ericales
Family: Ericaceae
Genus: Vaccinium
Subgenus: Oxycoccus
Species

Vaccinium erythrocarpum
Vaccinium macrocarpon
Vaccinium microcarpum
Vaccinium oxycoccos

Cranberries are a group of evergreen dwarf shrubs or trailing vines in the subgenus Oxycoccus of the genus Vaccinium. In some methods of classification, Oxycoccus is regarded as a genus in its own right.[1] They can be found in acidic bogs throughout the cooler regions of the northern hemisphere.

Cranberries are low, creeping shrubs or vines up to 2 metres (7 ft) long and 5 to 20 centimetres (2 to 8 in) in height;[2] they have slender, wiry stems that are not thickly woody and have small evergreen leaves. The flowers are dark pink, with very distinct reflexed petals, leaving the style and stamens fully exposed and pointing forward. They are pollinated by bees. The fruit is a berry that is larger than the leaves of the plant; it is initially white, but turns a deep red when fully ripe. It is edible, with an acidic taste that can overwhelm its sweetness.

Cranberries are a major commercial crop in certain American states and Canadian provinces (see cultivation and uses below). Most cranberries are processed into products such as juice, sauce, jam, and sweetened dried cranberries, with the remainder sold fresh to consumers. Cranberry sauce is a traditional accompaniment to turkey at Thanksgiving dinners in the United States. [3]

Since the early 21st century within the global functional food industry, raw cranberries have been marketed as a "superfruit" due to their nutrient content and antioxidant qualities.[4][5]

Species and description[edit]

Approximate ranges of the cranberries in sect. Oxycoccus: Red: Common Cranberry. Orange: Small Cranberry. Green: American Cranberry.

There are three to four species of cranberry, classified in two sections:

Subgenus Oxycoccus, sect. Oxycoccus
  • Vaccinium oxycoccos or Oxycoccus palustris (Common Cranberry or Northern Cranberry) is widespread throughout the cool temperate northern hemisphere, including northern Europe, northern Asia and northern North America. It has small 5–10 mm leaves. The flowers are dark pink, with a purple central spike, produced on finely hairy stems. The fruit is a small pale pink berry, with a refreshing sharp acidic flavour.
  • Vaccinium microcarpum or Oxycoccus microcarpus (Small Cranberry) occurs in northern North America,[6] northern Europe and northern Asia, and differs from V. oxycoccos in the leaves being more triangular, and the flower stems hairless. Some botanists include it within V. oxycoccos.
  • Vaccinium macrocarpon or Oxycoccus macrocarpus (Large cranberry, American Cranberry, Bearberry) native to northern North America across Canada, and eastern United States, south to North Carolina at high altitudes). It differs from V. oxycoccos in the leaves being larger, 10–20 mm long, and in its slightly apple-like taste.
Subgenus Oxycoccus, sect. Oxycoccoides
Vaccinium oxycoccos flowers

Cranberries are related to bilberries, blueberries, and huckleberries, all in Vaccinium subgenus Vaccinium. These differ in having stouter, woodier stems forming taller shrubs, and in the bell-shaped flowers, the petals not being reflexed.

Some plants of the completely unrelated genus Viburnum are sometimes inaccurately called "highbush cranberries" (Viburnum trilobum).

Cranberries are susceptible to false blossom, a harmful but controllable phytoplasma disease common in the eastern production areas of Massachusetts and New Jersey.

Etymology and history[edit]

The Cranberry Harvest on the Island of Nantucket, Eastman Johnson, 1880.

The name cranberry derives from "craneberry", first named by early European settlers in America who felt the expanding flower, stem, calyx, and petals resembled the neck, head, and bill of a crane. Another name used in northeastern Canada is mossberry. The traditional English name for Vaccinium oxycoccos, fenberry, originated from plants found growing in fen (marsh) lands. In 17th-century New England cranberries were sometimes called "bearberries" as bears were often seen feeding on them.

Annual U.S. Crops of Cranberries, 1907 to 1935

In North America, Native Americans were the first to use cranberries as food. Native Americans used cranberries in a variety of foods, especially for pemmican, wound medicine, and dye. Calling the red berries Sassamanash, Algonquian peoples may have introduced cranberries to starving English settlers in Massachusetts who incorporated the berries into traditional Thanksgiving feasts. American Revolutionary War veteran Henry Hall is credited as first to farm cranberries in the Cape Cod town of Dennis around 1816. In the 1820s cranberries were shipped to Europe.[7] Cranberries became popular for wild harvesting in the Nordic countries and Russia. In Scotland the berries were originally wild-harvested but, with the loss of suitable habitat, the plants have become so scarce that this is no longer done.

Cultivation[edit]

Geography and bog method[edit]

Cranberry harvest in New Jersey

Cranberries are a major commercial crop in the U.S. states of Massachusetts, New Jersey, Oregon, Washington, and Wisconsin, as well as in the Canadian provinces of British Columbia, New Brunswick, Ontario, Nova Scotia, Prince Edward Island, Newfoundland and Quebec. 20% of the world's cranberries are produced in British Columbia's Lower Mainland region. In the United States, Wisconsin is the leading producer of cranberries, with over half of U.S. production.[8] Massachusetts is the second largest U.S. producer. A very small production is found in southern Argentina and Chile, the Netherlands,[9] and Eastern Europe.[citation needed]

Historically, cranberry beds were constructed in wetlands. Today's cranberry beds are constructed in upland areas with a shallow water table. The topsoil is scraped off to form dykes around the bed perimeter. Clean sand is hauled into a depth of four to eight inches. The surface is laser leveled flat to provide even drainage. Beds are frequently drained with socked tile in addition to the perimeter ditch. In addition to making it possible to hold water, the dykes allow equipment to service the beds without driving on the vines. Irrigation equipment is installed in the bed to provide irrigation for vine growth and for spring and autumn frost protection.

Cultivation[edit]

Dried cranberries

Cranberry vines are propagated by moving vines from an established bed. The vines are spread on the surface of the sand of the new bed and pushed into the sand with a blunt disk. The vines are watered frequently during the first few weeks until roots form and new shoots grow. Beds are given frequent light application of nitrogen fertilizer during the first year. The cost of establishment for new cranberry beds is estimated to be about US$70,000 per hectare (approx. $28,300 per acre).

A common misconception about cranberry production is that the beds remain flooded throughout the year. During the growing season cranberry beds are not flooded, but are irrigated regularly to maintain soil moisture. Beds are flooded in the autumn to facilitate harvest and again during the winter to protect against low temperatures. In cold climates like Wisconsin, Maine, and eastern Canada, the winter flood typically freezes into ice, while in warmer climates the water remains liquid. When ice forms on the beds, trucks can be driven onto the ice to spread a thin layer of sand that helps to control pests and rejuvenate the vines. Sanding is done every three to five years.

Harvesting[edit]

Cranberry harvest (wet-picking)

Cranberries are harvested in the fall when the fruit takes on its distinctive deep red color. This is usually in September through the first part of November. To harvest cranberries, the beds are flooded with six to eight inches of water above the vines. A harvester is driven through the beds to remove the fruit from the vines. For the past 50 years, water reel type harvesters have been used. Harvested cranberries float in the water and can be corralled into a corner of the bed and conveyed or pumped from the bed. From the farm, cranberries are taken to receiving stations where they are cleaned, sorted, and stored prior to packaging or processing.

Although most cranberries are wet-picked as described above, 5–10% of the US crop is still dry-picked. This entails higher labor costs and lower yield, but dry-picked berries are less bruised and can be sold as fresh fruit instead of having to be immediately frozen or processed. Originally performed with two-handed comb scoops, dry picking is today accomplished by motorized, walk-behind harvesters which must be small enough to traverse beds without damaging the vines.

White cranberry juice is made from regular cranberries that have been harvested after the fruits are mature, but before they have attained their characteristic dark red color. Yields are lower on beds harvested early and the early flooding tends to damage vines, but not severely.

Cranberries for fresh market are stored in shallow bins or boxes with perforated or slatted bottoms, which deter decay by allowing air to circulate. Because harvest occurs in late autumn, cranberries for fresh market are frequently stored in thick walled barns without mechanical refrigeration. Temperatures are regulated by opening and closing vents in the barn as needed. Cranberries destined for processing are usually frozen in bulk containers shortly after arriving at a receiving station.

Food uses[edit]

Cranberries

As fresh cranberries are hard and bitter, about 95% of cranberries are processed and used to make cranberry juice and sauce. They are also sold dried and sweetened.[10]

Cranberry juice is usually sweetened or blended with other fruit juices to reduce its natural tartness. Many cocktails, including the Cosmopolitan, are made with cranberry juice. At one teaspoon of sugar per ounce, cranberry juice cocktail is more highly sweetened than even soda drinks that have been linked to obesity.[11]

Usually cranberries as fruit are cooked into a compote or jelly, known as cranberry sauce. Such preparations are traditionally served with roast turkey, as a staple of English Christmas dinners, and the Canadian and US holiday Thanksgiving. The berry is also used in baking (muffins, scones, cakes and breads). In baking it is often combined with orange or orange zest. Less commonly, innovative cooks use cranberries to add tartness to savory dishes such as soups and stews.[10]

Fresh cranberries can be frozen at home, and will keep up to nine months; they can be used directly in recipes without thawing.[12]

Cranberry wine is made in some of the cranberry-growing regions of the United States and Canada from either whole cranberries, cranberry juice or cranberry juice concentrate.

Potential health effects[edit]

Nutrients[edit]

Cranberries, raw
Nutritional value per 100 g (3.5 oz)
Energy 46 kcal (190 kJ)
12.2 g
Sugars 4.04 g
Dietary fiber 4.6 g
0.13 g
0.39 g
Vitamins
Vitamin A equiv.
(0%)
3 μg
(0%)
36 μg
91 μg
Thiamine (B1)
(1%)
0.012 mg
Riboflavin (B2)
(2%)
0.02 mg
Niacin (B3)
(1%)
0.101 mg
(6%)
0.295 mg
Vitamin B6
(4%)
0.057 mg
Folate (B9)
(0%)
1 μg
Vitamin C
(16%)
13.3 mg
Vitamin E
(8%)
1.2 mg
Vitamin K
(5%)
5.1 μg
Trace metals
Calcium
(1%)
8 mg
Iron
(2%)
0.25 mg
Magnesium
(2%)
6 mg
Manganese
(17%)
0.36 mg
Phosphorus
(2%)
13 mg
Potassium
(2%)
85 mg
Sodium
(0%)
2 mg
Zinc
(1%)
0.1 mg
Other constituents
Water 87.13 g

Percentages are roughly approximated using US recommendations for adults.
Source: USDA Nutrient Database

Raw cranberries have moderate levels of vitamin C, dietary fiber and the essential dietary mineral, manganese, (each nutrient having more than 10% of the Daily Value per 100 g serving; see right table) as well as other essential micronutrients in minor amounts.[13]

Phytochemicals[edit]

Raw cranberries are a source of polyphenols which are under active research for possible benefits to the cardiovascular system and immune system, and as anti-cancer agents,[14][15] such as in isolated prostate cancer cells.[16] However, it is uncertain whether polyphenols account for the benefits of diets rich in plant foods like cranberries.[15]

Cranberry juice contains a high molecular weight non-dializable material that is under research for its potential to affect formation of plaque by Streptococcus mutans pathogens that cause tooth decay.[17] Cranberry juice components are also being studied for possible effects on kidney stone formation.[18][19]

One study showed that cranberries had a high amount of total polyphenols[20] and tannins having laboratory evidence for inhibition of anti-clotting properties and urinary tract infections in women,[21] but a review of available research concluded that there is insufficient scientific support for efficacy of cranberry compounds in treating UTIs.[22] Long-term tolerance is also an issue.[22]

Raw cranberries and cranberry juice are abundant food sources of polyphenols such as proanthocyanidins, flavonols [23] and quercetin.[24][25] These compounds have shown possible activity as anti-cancer agents in vitro.[26][27][28][29][30] However, their effectiveness in humans remains unknown, and is limited by poor absorption into cells and rapid excretion.

Cranberry tannins may interact with proteins and possibly digestive enzymes, α-amylase and glucoamylase, which in turn may affect starch hydrolysis, as shown in one in vitro study.[31]

Potential anti-adhesion properties[edit]

There is potential benefit of cranberry juice consumption (300 mL of cranberry juice per day) against bacterial infections in the urinary system.[32] Laboratory research shows that a possible effect may occur from a component of the juice inhibiting bacterial attachment to the bladder and urethra.[33][34][35]

The effect may not result from the acidic nature of polyphenols but possibly to a specific A type proanthocyanidin which is thought to inhibit adherence of E. coli and other fimbriated bacteria to uroepithelial cells.[36][37]

Although promising for anti-bacterial activity, long-term consumption of cranberry juice has not been adequately proven to reduce urinary tract infections. However, there is preliminary evidence for possible effects against urinary tract infections in women.[38][39] Similar applications have not been successfully proven in other clinical trials of consuming cranberry juice or tablets by people with spinal cord injury associated with bladder catheterization, neurogenic bladder or infrequent urination, any of which may be associated with increased susceptibility to bacterial infections.[40][41][42]

In a 2014 review of a product containing high content of cranberry proanthocyanidins, the European Food Safety Authority concluded there was insufficient evidence for a cause and effect relationship between consumption of cranberry proanthocyanidins and a lower risk of urinary tract infection.[43]

Possible contraindications[edit]

An autumn 2004 caution from the Committee on Safety of Medicines, the UK agency dealing with drug safety, advised patients taking warfarin not to drink cranberry juice after adverse effects (such as increased incidence of bruising) were reported, possibly resulting from the presence of salicylic acid native to polyphenol-rich plants such as the cranberry. However, during 2006–08, several reviews of case reports and pilot studies failed to confirm this effect, collectively indicating no statistically significant interaction between daily consumption of 250 mL cranberry juice and warfarin in the general population.[44][45] A gene (VKORC1, CYP2C9) has been shown to change warfarin sensitivity. This gene may also contribute to bruising susceptibility as a result of cranberries for carriers of the gene. A couple of possible cases of warfarin interaction with cranberry have been reported.[46]

Marketing and economics[edit]

History[edit]

In 1550, James White Norwood made reference to Indians using cranberries. In James Rosier's book The Land of Virginia there is an account of Europeans coming ashore and being met with Indians bearing bark cups full of cranberries. In Plymouth, Massachusetts, there is a 1633 account of the husband of Mary Ring auctioning her cranberry-dyed petticoat for 16 shillings. In 1640's Key Into the Language Roger Williams described cranberries, referring to them as "bearberries" because bears ate them. In 1648, preacher John Elliott was quoted in Thomas Shepard's book Clear Sunshine of the Gospel with an account of the difficulties the Pilgrims were having in using the Indians to harvest cranberries as they preferred to hunt and fish. In 1663, the Pilgrim cookbook appears with a recipe for cranberry sauce. In 1667, New Englanders sent to King Charles 10 barrels of cranberries, 3 barrels of codfish and some Indian corn as a means of appeasement for his anger over their local coining of the Pine Tree shilling. In 1669, Captain Richard Cobb had a banquet in his house (to celebrate both his marriage to Mary Gorham and his election to the Convention of Assistance), serving wild turkey with sauce made from wild cranberries. In the 1672 book New England Rarities Discovered author John Josselyn described cranberries, writing:

"Sauce for the Pilgrims, cranberry or bearberry, is a small trayling plant that grows in salt marshes that are overgrown with moss. The berries are of a pale yellow color, afterwards red, as big as a cherry, some perfectly round, others oval, all of them hollow with sower (sic) astringent taste; they are ripe in August and September. They are excellent against the Scurvy. They are also good to allay the fervor of hoof diseases. The Indians and English use them mush, boyling (sic) them with sugar for sauce to eat with their meat; and it is a delicate sauce, especially with roasted mutton. Some make tarts with them as with gooseberries."

The Compleat Cook's Guide, published in 1683, made reference to cranberry juice.[citation needed] In 1703, cranberries were served at the Harvard University commencement dinner.[citation needed] In 1787, James Madison wrote Thomas Jefferson in France for background information on constitutional government to use at the Constitutional Convention. Jefferson sent back a number of books on the subject and in return asked for a gift of apples, pecans and cranberries.[citation needed] William Aiton, a Scottish botanist, included an entry for the cranberry in volume II of his 1789 work Hortus Kewensis. He notes that Vaccinium macrocarpon (American cranberry) was cultivated by James Gordon in 1760.[citation needed] In 1796, cranberries were served at the first celebration of the landing of the Pilgrims, and Amelia Simmons (an American orphan) wrote a book entitled American Cookery which contained a recipe for cranberry tarts.[citation needed] In 1816, Henry Hall first commercially grew cranberries in East Dennis, Massachusetts on Cape Cod.[citation needed] In 1843, Eli Howes planted his own crop of cranberries on Cape Cod, using the "Howes" variety.[citation needed] In 1847, Cyrus Cahoon planted a crop of "Early Black" variety near Pleasant Lake, Harwich, Massachusetts.[citation needed] In 1860, Edward Watson, a friend of Henry David Thoreau, wrote a poem called "The Cranberry Tart."[citation needed]

Cranberry sales in the United States have traditionally been associated with holidays of Thanksgiving and Christmas. Until the 1930s most of the crop was sold fresh.[citation needed]

In the U.S., large scale cranberry cultivation has been developed as opposed to other countries.[citation needed] American cranberry growers have a long history of cooperative marketing. As early as 1904, John Gaynor, a Wisconsin grower, and A.U. Chaney, a fruit broker from Des Moines, Iowa, organized Wisconsin growers into a cooperative called the Wisconsin Cranberry Sales Company to receive a uniform price from buyers.[citation needed] Growers in New Jersey and Massachusetts were also organized into cooperatives, creating the National Fruit Exchange that marketed fruit under the Eatmor brand.[citation needed] The success of cooperative marketing almost led to its failure. With consistent and high prices, area and production doubled between 1903 and 1917 and prices fell. In 1918, US$54,000 was spent on advertising, leading to US$1 million in increased sales.[citation needed]

With surplus cranberries and changing American households some enterprising growers began canning cranberries that were below-grade for fresh market. Competition between canners was fierce because profits were thin. The Ocean Spray cooperative was established in 1930 through a merger of three primary processing companies: Ocean Spray Preserving company, Makepeace Preserving Co, and Cranberry Products Co. The new company was called Cranberry Canners, Inc. and used the Ocean Spray label on their products. Since the new company represented over 90% of the market, it would have been illegal (cf. antitrust) had attorney John Quarles not found an exemption for agricultural cooperatives. Morris April Brothers were the producers of Eatmor brand cranberry sauce, in Tuckahoe, New Jersey; Morris April Brothers brought an action against Ocean Spray for violation of the Sherman Antitrust Act and won $200,000 in real damages plus triple damages, in 1958, just in time for the Great Cranberry Scare of 1959. As of 2006, about 65% of the North American industry belongs to the Ocean Spray cooperative. (The percentage may be slightly higher in Canada than in the U.S.)

A turning point for the industry occurred on November 9, 1959, when the secretary of the United States Department of Health, Education, and Welfare Arthur S. Flemming announced that some of the 1959 crop was tainted with traces of the herbicide aminotriazole. The market for cranberries collapsed and growers lost millions of dollars.[10][47] However, the scare taught the industry that they could not be completely dependent on the holiday market for their products: they had to find year-round markets for their fruit. They also had to be exceedingly careful about their use of pesticides.

After the aminotriazole scare, Ocean Spray reorganized and spent substantial sums on product development. New products such as cranberry/apple juice blends were introduced, followed by other juice blends.

A Federal Marketing Order that is authorized to synchronize supply and demand was approved in 1962. The order has been renewed and modified slightly in subsequent years, but it has allowed for more stable marketing. The market order has been invoked during six crop years: 1962 (12%), 1963 (5%), 1970 (10%), 1971 (12%), 2000 (15%), and 2001 (35%). Even though supply still exceeds demand, there is little will to invoke the Federal Marketing Order out of the realization that any pullback in supply by U.S. growers would easily be filled by Canadian production.

Prices and production increased steadily during the 1980s and 1990s. Prices peaked at about $65.00 per barrel (29 ¢/kg—a cranberry barrel equals 100 pounds or 45.4 kg.) in 1996 then fell to $18.00 per barrel (8.2 ¢/kg) in 2001. The cause for the precipitous drop was classic oversupply. Production had outpaced consumption leading to substantial inventory in freezers or as concentrate.

Cranberry handlers (processors) include Ocean Spray, Cliffstar Corporation, Northland Cranberries Inc.[Sun Northland LLC], Clement Pappas & Co., Decas Cranberry Products as well as a number of small handlers and processors.[48]

Cranberry Marketing Committee[edit]

The Cranberry Marketing Committee of the United States of America is an organization that represents 100% of the United States cranberry handlers in four marketing order districts. The committee was established in 1963 as a Federal Marketing Order to safeguard the orderly supply of a quality product. The Cranberry Marketing Committee, based in Wareham, Massachusetts, represents 18 cranberry handlers which represents about 1,200 United States cranberry growers located in Oregon, Connecticut, Massachusetts, Michigan, Minnesota, New Jersey, New York, Rhode Island, Washington, and Wisconsin. The authority for the actions taken by the Cranberry Marketing Committee are provided in Chapter IX, Title 7, Code of Federal Regulations which is called the Federal Cranberry Marketing Order. The Order is part of the Agricultural marketing Agreement Act of 1937. The act identifies cranberries as a commodity good that can be regulated by Congress. The Federal Cranberry Marketing Order has been altered over the years to expand the Cranberry Marketing Committees ability to develop projects in the United States and around the world. The Cranberry Marketing Committee currently runs promotional programs in the United States, South Korea, the Netherlands, Austria, Australia, Switzerland, France, Poland, Czech Republic, Germany, and Mexico. [49]

Regulation[edit]

Problems may arise with the lack of validation of a quantifying method for the quantification of A-type proanthocyanidins. For instance, in the case of cranberry extracts, it can be performed using several existing methods including for example the European Pharmacopoeia method, LC-MS[50] or a modified 4-dimethylaminocinnamaldehyde (DMAC) colorimetric method.[51] This can lead to difficulties in evaluating the real quality of extracts from different origins: assessments show that quality varies greatly from one commercial product to another.[52]

References[edit]

  1. ^ Steven Clemants. "Vaccinium oxycoccos: Small Cranberry, Technical Page". Brooklyn Botanic Garden. 
  2. ^ "About Cranberries". Cranberry Institute. Retrieved 2009-11-13. 
  3. ^ Carol Cloud Bailey (2009-11-19). "Garden Tips: Give thanks for cranberries, grown with a taste of Florida". TCPalm.com. Scripps Interactive Newspapers Group. Retrieved 2009-11-20. 
  4. ^ "Cranberries: How Ocean Spray made them the world’s most successful superfruit". New Nutrition Business. Retrieved 21 October 2011. 
  5. ^ "Newsroom – 'Superfruits' the future of health". HortResearch. Archived from the original on 23 Mar 2010. Retrieved 10 April 2014. 
  6. ^ "borealforest.org". Lakehead University Faculty of Natural Resources Management. 
  7. ^ "History". Cranberries.org. Retrieved 2009-11-13. 
  8. ^ United States Department of Agriculture (18 August 2010). "Wisconsin -Cranberries". Retrieved 31 July 2011 
  9. ^ "Cranberry Terschelling BV". Retrieved 19 November 2011. 
  10. ^ a b c Zeldes, Leah A. (November 25, 2009). "Eat this! Cranberries more than a thanksgiving condiment". Dining Chicago. Chicago's Restaurant & Entertainment Guide, Inc. Retrieved Nov 25, 2009. 
  11. ^ Calvan, Bobby Caina. "Cranberry industry seeks to avoid school ban." Boston Globe, 25 June 2012.
  12. ^ "The American Cranberry-Basic Information on Cranberries". Library.wisc.edu. Retrieved 2010-10-04. 
  13. ^ "Nutrition facts for raw cranberries". Nutritiondata.com. Conde Nast. 2013. Retrieved 19 January 2014. 
  14. ^ Seifried HE, Anderson DE, Fisher EI, Milner JA (September 2007). "A review of the interaction among dietary antioxidants and reactive oxygen species". J Nutr Biochem. 18 (9): 567–79. doi:10.1016/j.jnutbio.2006.10.007. PMID 17360173. 
  15. ^ a b Halliwell B (January 2007). "Dietary polyphenols: good, bad, or indifferent for your health?". Cardiovasc Res. 73 (2): 341–7. doi:10.1016/j.cardiores.2006.10.004. PMID 17141749. 
  16. ^ MacLean MA, Scott BE, Deziel BA, Nunnelley MC, Liberty AM, Gottschall-Pass KT, Neto CC, Hurta RA"North American cranberry (Vaccinium macrocarpon) stimulates apoptotic pathways in DU145 human prostate cancer cells in vitro." Nutr Cancer. 2011 Jan;63(1):109-20
  17. ^ "Blocking tooth decay". Webmd.com. 2005-11-23. Retrieved 2009-11-13. 
  18. ^ McHarg T, Rodgers A, Charlton K (November 2003). "Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation". BJU Int. 92 (7): 765–8. doi:10.1046/j.1464-410X.2003.04472.x. PMID 14616463. 
  19. ^ Kessler T, Jansen B, Hesse A (October 2002). "Effect of blackcurrant-, cranberry- and plum juice consumption on risk factors associated with kidney stone formation". Eur J Clin Nutr 56 (10): 1020–3. doi:10.1038/sj.ejcn.1601442. PMID 12373623. 
  20. ^ Vinson JA, Su X, Zubik L, Bose P (November 2001). "Phenol antioxidant quantity and quality in foods: fruits". J Agric Food Chem. 49 (11): 5315–21. doi:10.1021/jf0009293. PMID 11714322. 
  21. ^ Efros M. Bromberg W. Cossu L. Nakeleski E. Katz AE."Novel concentrated cranberry liquid blend, UTI-STAT with Proantinox, might help prevent recurrent urinary tract infections in women." Urology. 76(4):841-5, 2010 Oct.
  22. ^ a b Jepson, RG; Williams, G; Craig, JC (Oct 17, 2012). "Cranberries for preventing urinary tract infections". In Jepson, Ruth G. Cochrane database of systematic reviews (Online) 10: CD001321. doi:10.1002/14651858.CD001321.pub5. PMID 23076891. 
  23. ^ Vvedenskaya, Irina O; Vorsa, Nicholi (2004). "Flavonoid composition over fruit development and maturation in American cranberry, Vaccinium macrocarpon Ait". Plant Science 167 (5): 1043. doi:10.1016/j.plantsci.2004.06.001. 
  24. ^ Duthie SJ, Jenkinson AM, Crozier A, et al. (March 2006). "The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers". Eur J Nutr 45 (2): 113–22. doi:10.1007/s00394-005-0572-9. PMID 16032375. 
  25. ^ Zheng W, Wang SY (January 2003). "Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries". J Agric Food Chem. 51 (2): 502–9. doi:10.1021/jf020728u. PMID 12517117. 
  26. ^ Cancer Research Society Newsletter : The Cranberry – A Natural and Delicious Antidote
  27. ^ Neto CC (June 2007). "Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases". Mol Nutr Food Res 51 (6): 652–64. doi:10.1002/mnfr.200600279. PMID 17533651. 
  28. ^ Ferguson PJ, Kurowska EM, Freeman DJ, Chambers AF, Koropatnick J (2006). "In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract". Nutr Cancer 56 (1): 86–94. doi:10.1207/s15327914nc5601_12. PMID 17176222. 
  29. ^ Seeram NP, Adams LS, Zhang Y, et al. (December 2006). "Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro". J Agric Food Chem. 54 (25): 9329–39. doi:10.1021/jf061750g. PMID 17147415. 
  30. ^ Sun J, Chu YF, Wu X, Liu RH (December 2002). "Antioxidant and antiproliferative activities of common fruits". J Agric Food Chem. 50 (25): 7449–54. doi:10.1021/jf0207530. PMID 12452674. 
  31. ^ Inhibition of a-amylase and glucoamylase by tannins extracted from cocoa, pomegranates, cranberries and grapes. Ann Barrett, Christine A Hughey, Christine Straut, Amy B. Howell, Tshinanne Ndou, Zifei Dai, and Gonul Kaletunc. J. Agric. Food Chem. doi:10.1021/jf304876g Publication Date (Web): January 5, 2013
  32. ^ Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 1994;271:751-754.
  33. ^ "Cranberry juice creates energy barrier that keeps bacteria away from cells, study shows". Eurekalert.org. 2008-07-21. Retrieved 2009-11-13. 
  34. ^ "Compounds in cranberry juice show promise as alternatives to antibiotics". Physorg.com. 2006-09-11. Retrieved 2009-11-13. 
  35. ^ "How Cranberry Juice Can Prevent Urinary Tract Infections". Sciencedaily.com. 2008-07-25. Retrieved 2009-11-13. 
  36. ^ Zafriri D, Ofek I, Adar R, Pocino M, Sharon N. Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells. Antimicrob Agents Chemother 1989;33:92-98.
  37. ^ Ofek I, Goldhar J, Zafriri D, Lis H, Adar R, Sharon N. Anti-Escherichia coli adhesin activity of cranberry and blueberry juices. N Engl J Med 1991;324:1599-1599.
  38. ^ Jepson RG, Mihaljevic L, Craig J (2004). "Cranberries for preventing urinary tract infections". In Jepson, Ruth. Cochrane Database Syst Rev (2): CD001321. doi:10.1002/14651858.CD001321.pub3. PMID 15106157. 
  39. ^ Risco E, Miguélez C, Sánchez de Badajoz E, Rouseaud A.,"Effect of American cranberry (Cysticlean) on Escherichia coli adherence to bladder epithelial cells. In vitro and in vivo study." Arch Esp Urol. 2010 Jul-Aug;63(6):422-30
  40. ^ Linsenmeyer TA, Harrison B, Oakley A, Kirshblum S, Stock JA, Millis SR (2004). "Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study". J Spinal Cord Med 27 (1): 29–34. PMID 15156934. 
  41. ^ Waites KB, Canupp KC, Armstrong S, DeVivo MJ (2004). "Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury". J Spinal Cord Med 27 (1): 35–40. PMID 15156935. 
  42. ^ Lee BB, Haran MJ, Hunt LM, et al. (August 2007). "Spinal-injured neuropathic bladder antisepsis (SINBA) trial". Spinal Cord 45 (8): 542–50. doi:10.1038/sj.sc.3101974. PMID 17043681. 
  43. ^ "Scientific Opinion on the substantiation of a health claim related to CranMax® and reduction of the risk of urinary tract infection by inhibiting the adhesion of certain bacteria in the urinary tract pursuant to Article 14 of Regulation (EC) No 1924/20061". EFSA Journal (European Food Safety Authority) 12 (5): 3657. 2014. Retrieved 22 May 2014. 
  44. ^ Li Z, Seeram NP, Carpenter CL, Thames G, Minutti C, Bowerman S (December 2006). "Cranberry does not affect prothrombin time in male subjects on warfarin". J Am Diet Assoc 106 (12): 2057–61. doi:10.1016/j.jada.2006.09.012. PMID 17126638. 
  45. ^ Pham DQ, Pham AQ (March 2007). "Interaction potential between cranberry juice and warfarin". Am J Health Syst Pharm 64 (5): 490–4. doi:10.2146/ajhp060370. PMID 17322161. 
  46. ^ Hamann GL, Campbell JD, George CM.,"Warfarin-Cranberry Juice Interaction (March)." Ann Pharmacother. 2011 Mar 1;
  47. ^ ""Cranberry Blues" 1959 recording (mp3 file) by Robert Williams and the Groovers". Retrieved 2009-11-25. 
  48. ^ Roper TR, Vorsa N (1997). "Cranberry: Botany and Horticulture". In Janick J. Horticultural Reviews. New York: Wiley. pp. 215–6. ISBN 0-471-18907-3. 
  49. ^ http://www.uscranberries.com/About/
  50. ^ Tarascou, Isabelle; Mazauric, Jean-Paul; Meudec, Emmanuelle; Souquet, Jean-Marc; Cunningham, David; Nojeim, Steve; Cheynier, Véronique; Fulcrand, Hélène (2011). "Characterisation of genuine and derived cranberry proanthocyanidins by LC–ESI-MS". Food Chemistry 128 (3): 802. doi:10.1016/j.foodchem.2011.03.062. 
  51. ^ Prior, Ronald L; Fan, Ellen; Ji, Hongping; Howell, Amy; Nio, Christian; Payne, Mark J; Reed, Jess (2010). "Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders". Journal of the Science of Food and Agriculture 90 (9): 1473–8. doi:10.1002/jsfa.3966. PMID 20549799. 
  52. ^ Sánchez-Patán, Fernando; Bartolomé, Begoña; Martín-Alvarez, Pedro J.; Anderson, Mark; Howell, Amy; Monagas, María (2012). "Comprehensive Assessment of the Quality of Commercial Cranberry Products. Phenolic Characterization and in Vitro Bioactivity". Journal of Agricultural and Food Chemistry 60 (13): 3396–408. doi:10.1021/jf204912u. PMID 22439747. 

Further reading[edit]

Books
  • Cole, S. / Gifford, L. (2009). The Cranberry: Hard Work and Holiday Sauce. Tilbury House Publishers. ISBN 978-0-88448-316-8
  • Trehane, J. (2009). Blueberries, Cranberries and Other Vacciniums. Timber Press. ISBN 978-1-60469-072-9

External links[edit]