FSHB

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Follicle stimulating hormone, beta polypeptide
Protein FSHB PDB 1fl7.png
PDB rendering based on 1fl7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol FSHB
External IDs OMIM136530 MGI95582 HomoloGene430 GeneCards: FSHB Gene
RNA expression pattern
PBB GE FSHB 214489 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2488 14308
Ensembl ENSG00000131808 ENSMUSG00000027120
UniProt P01225 Q60687
RefSeq (mRNA) NM_000510 NM_008045
RefSeq (protein) NP_000501 NP_032071
Location (UCSC) Chr 11:
30.25 – 30.26 Mb
Chr 2:
107.06 – 107.06 Mb
PubMed search [1] [2]

Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded by the FSHB gene.[1][2][3] Alternative splicing results in two transcript variants encoding the same protein.

Function[edit]

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]

References[edit]

  1. ^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163. 
  2. ^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J Protein Chem 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250. 
  3. ^ a b "Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide". 

Further reading[edit]

  • Barrios-De-Tomasi J, Timossi C, Merchant H et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones". Mol. Cell. Endocrinol. 186 (2): 189–98. doi:10.1016/S0303-7207(01)00657-8. PMID 11900895. 
  • Saxena BB, Rathnam P (1976). "Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands". J. Biol. Chem. 251 (4): 993–1005. PMID 1249074. 
  • Keene JL, Matzuk MM, Otani T et al. (1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells". J. Biol. Chem. 264 (9): 4769–75. PMID 2494176. 
  • Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids". Mol. Endocrinol. 2 (9): 806–15. doi:10.1210/mend-2-9-806. PMID 3139991. 
  • Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)". J. Clin. Endocrinol. Metab. 39 (1): 203–5. doi:10.1210/jcem-39-1-203. PMID 4835136. 
  • Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone". Biochim. Biophys. Acta 624 (2): 428–35. doi:10.1016/0005-2795(80)90084-7. PMID 6774759. 
  • Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men". Cell Tissue Res. 278 (3): 595–600. doi:10.1007/BF00331379. PMID 7850869. 
  • Matthews CH, Borgato S, Beck-Peccoz P et al. (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone". Nat. Genet. 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432. 
  • Layman LC, Lee EJ, Peak DB et al. (1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene". N. Engl. J. Med. 337 (9): 607–11. doi:10.1056/NEJM199708283370905. PMID 9271483. 
  • Cargill M, Altshuler D, Ireland J et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1–3): 67–71. doi:10.1016/S0167-0115(99)00022-1. PMID 10395410. 
  • Ben-Menahem D, Hyde R, Pixley M et al. (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry 38 (46): 15070–7. doi:10.1021/bi991510c. PMID 10563789. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Fox KM, Dias JA, Van Roey P (2001). "Three-dimensional structure of human follicle-stimulating hormone". Mol. Endocrinol. 15 (3): 378–89. doi:10.1210/me.15.3.378. PMID 11222739. 
  • Amoresano A, Orrù S, Siciliano RA et al. (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain". Biol. Chem. 382 (6): 961–8. doi:10.1515/BC.2001.120. PMID 11501762. 
  • Walton WJ, Nguyen VT, Butnev VY et al. (2001). "Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. Clin. Endocrinol. Metab. 86 (8): 3675–85. doi:10.1210/jc.86.8.3675. PMID 11502795.