Gajendra Pal Singh Raghava

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Dr. G. P. S. Raghava

Dr. G.P.S. Raghava
Born Uttar Pradesh, India
Residence India
Nationality Indian
Fields Bioinformatics
Institutions Institute of Microbial Technology
Bioinformatics Centre

Gajendra Pal Singh Raghava is a bio-informatician and head of the Bioinformatics Centre at the Institute of Microbial Technology (IMTECH).

Contents

[edit] Personal

[edit] Early years and Education

Raghava was born in village Nagla Karan, Buland Shahr (UP), India in 1963. He did his B.Sc./M.Sc. from N.A.S. College, Meerut, UP in 1982. His major subjects were Physics, Chemistry and Mathematics. He did his M.Sc in Physics with specialization in electronics from N.A.S. College, Meerut, UP in 1984. He did his M.Tech from Indian Institute of Technology (I.I.T.), New Delhi in 1986. In 1996 he received a doctorate in bioinformatics from Institute of Microbial Technology and Panjab University, Chandigarh. His thesis was on "Computer Aided Prediction of Protein Conformation from Amino Acid Sequences of Biotechnological Relevance".

[edit] Career and Higher Studies

He joined the Institute of Microbial Technology, Chandigarh in 1986 as a computer scientist and developer. He become head of the Bioinformatics Centre in 1994. He is also coordinator of the distributed information centre supported by DBT under the BTISNET programme, where his primary duty is to build and maintain infrastructure required for protein modeling and engineering.

He worked as a postdoctoral fellow at Oxford university as well as at the European Bioinformatics Institute (EBI) at Cambridge for two years (1996–98). During this period he learned and developed a number of web servers for application in computational biology, particularly in protein modelling.

[edit] Achievements and Awards

Dr G P S Raghava receiving India Research Front Award 2009
Dr G P S Raghava receiving S. S. Bhatnagar Award from Prime Minister Dr Manmohan Singh
Dr G P S Raghava receiving National Bioscience Award from Science and Technology minister Shri Kapil Sibal

[edit] Positions

[edit] Research interests

He developed a method for calculating concentration of antibodies and antigens from ELISA data, and he a prediction method for protein secondary structure prediction. In 1999 he established his research group at IMTECH with emphasis on protein structure prediction and genome annotation. In 2001, his group also focused on "Computer aided vaccine design" with emphasis on subunit vaccine design. Since 2006, his group is trying to integrate bioinformatics, chemoinformatics, pharmaco-informatics and clinical informatics in order to develop a single plate form for designing drugs in silico.

[edit] Web Services and Software

He is an adherent of public domain software or open source software, and his group both uses and develops free software for academic use. Recently his group have initiated a web portal Computational Resource for Drug Discovery (CRDD) under Open Source Drug Discovery . Services provided from his group can be broadly classified in the following categories.

[edit] Computer-aided Protein Structure Prediction

Table I Computer-aided Protein Structure Prediction software
APSSP2 PROCLASS PSA RPFOLD BTEVAL BetatPred2 BetatPred CHpredict AR_NHPred
TBBPred BetaTurns BhairPred OXBench StruComp GammaPred AlphaPred PepStr SarPred

[edit] Immunoinformatics: Subunit Vaccine design

Table II Immunoinformatics software
PROPRED1 nHLApred MMBpred Pcleavage TAPpred CTLpred PROPRED
HLADR4pred MHC2pred MHC MHCbench AbAg BCEpred ABCpred
BCIPep HLApred MHCBN HaptenDB HLA_affi FDR4 Tmhcpred
CBtope NPtope

[edit] Genome Annotation

Table III Genome Annotation software
FTG GWBLAST GWFASTA EGPred SVMgene
SRF MyPattern GeneBench FTGPred CDpred
DNAbinder Polyapred Pprint ECGpred SGpred
PHDcleav siRNApred DesiRm MARSpred Iccaars

[edit] Functional Annotation of Proteins

Table IV Functional Annotation software
AC2Dgel NRpred GPCRpred GPCRsclass ESLpred PSLpred BTXpred Mitpred ESLpred2
SRTpred Oxypred VGIchan HSLpred DNAsize GSTpred Mango LGEpred CytoPred
NTXpred VICMpred AlgPred PseaPred RSL-Pred AntiBP COPid siRNAPred ISSPred
SubMitPred CyclinPred ChemoPred TBPred ProPrint plPred PseaPred2 ChloroPred SPred
PFMPred CancerPred

[edit] Chemoinformatics and Pharmacoinformatics

Table V Chemoinformatics and Pharmacoinformatics software
DADPRED DMKPred KiDoQ AntiBP AntiBP2 TOXIpred

[edit] Unclassified webservers and webpages

Table VI
Crag CRIP HIVbio BioTherapy GDPbio DrugPedia
LibNet Address RBpred Hplot Mafft SFEpred
OC Web Protanal Strucomp Sci. Writ Aasim BioSuite

[edit] Databases

List of Databases developed
MHCBN BCIPEP HaptenDB FSGP PRRDB HMRbase
AntigenDB PolysacDB OXDBase BIAdb SFdbase HIVsir

[edit] News from Group

  • OSCAT2012 : 2nd International conference on open source for computer-aided Translational medicine.
  • PreMier: Identification of Mannose Interacting Residues Using Local Composition". Plos ONE 6: e24039
  • TumorHope : A database of tumor homing peptides
  • ccPDB: Compilation and creation of datasets from protein data bank. Nucleic Acids research, 2011
  • GenomeABC : A server for Benchmarking of Genome Assemblers.
  • DESTAMP: Designing of stable antibacterial peptides.
  • DRONA: Prediction of nucleic acids (DNA RNA) interacting residues in proteins

[edit] External links

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