Hypoalbuminemia (or hypoalbuminaemia) is a medical condition where blood levels of albumin are abnormally low. It is a type of hypoproteinemia.
Albumin is a major protein in the human body, making up about 55-60% of total human plasma protein by mass. Many hormones, drugs, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active. For example, calcium binds to albumin and hypoalbuminemia leads to an increase in free ionized calcium.