L. infantum is a model system for studies of DNA repair
Comparative bioinformatic analyses showed that the size of the L. infantum BRCA2 protein is approximately three-times smaller (125kD) than its human counterpart. Furthermore analyses revealed that LiBRCA2 possesses key features of the BRCA2 family. The smaller size of the Leishmania BRCA2 DNA repair protein has been exploited to better understand its function in homologous recombination and its interaction with the LiRAD51 recombinase.
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