Libman–Sacks endocarditis

From Wikipedia, the free encyclopedia
  (Redirected from Libman-Sacks endocarditis)
Jump to: navigation, search
Libman–Sacks endocarditis
Classification and external resources
ICD-10 I39, M32.1
ICD-9 710.0
DiseasesDB 29254
eMedicine med/1295
MeSH D008180

Libman–Sacks endocarditis (often misspelled Libmann-Sachs) is a form of nonbacterial endocarditis that is seen in systemic lupus erythematosus. It is one of the most common cardiac manifestations of lupus (the most common being pericarditis).[1]

It was first described by Emanuel Libman and Benjamin Sacks at Mount Sinai Hospital in New York City in 1924.[2][3] The association between Libman–Sacks endocarditis and antiphospholipid syndrome was first noted in 1985.


The vegetations are small and formed from strands of fibrin, neutrophils, lymphocytes, and histiocytes. The mitral valve is typically affected, and the vegetations occur on the ventricular and atrial surface of the valve. Libman-Sacks lesions rarely produce significant valve dysfunction and the lesions only rarely embolize.[4]


The pathology is the same as nonbacterial thrombotic endocarditis except focal necrosis (hematoxylin bodies) can be found only in Libman–Sacks endocarditis.[citation needed]


  1. ^ "Libman-Sakcs endocarditis". Mosby’s Medical, Nursing & Allied Health Dictionary (Fourth ed.). Mosby-YearBook, Inc. 1994. p. 907. 
  2. ^ Libman, E.; Sacks, B. (1924). "A hitherto undescribed form of valvular and mural endocarditis". Arch Intern Med 33 (6): 701–737. doi:10.1001/archinte.1924.00110300044002. 
  3. ^ " Libman-Sacks Endocarditis". Retrieved 2008-08-11. 
  4. ^ Doherty, N. E.; Siegel, R. J. (1985). "Cardiovascular manifestations of systemic lupus erythematosus". Am Heart J 110 (6): 1257–1265. doi:10.1016/0002-8703(85)90023-7. PMID 3907317.