From 2004 to 2006, Spence was a judge and mentor on Trouble TV's Bump'n'Grind. Shortly after, Spence became a judge on the television series Cirque de Celebrité on Sky1 from 2006 to 2007 and the American version Celebrity Circus for NBC in 2008. In 2009, Spence was artistic director of the Covent Garden dance studio, commonly known as Pineapple, when he appeared on a docu-soap Pineapple Dance Studios beginning 14 February 2010 which was a huge hit. However, after initially indicating that a second series would be produced, Sky1 reverted this decision, due to failing to come to terms with studio owner Debbie Moore.  Spence was then given his own Sky1 series, Louie Spence's Showbusiness in 2011; however, with the loss of the brand name, the show failed to take off and was cancelled after one season.
On 22 August 2013, Spence entered the Celebrity Big Brother house to participate in the twelfth series. On the first day, he was chosen to be a 'Cult celebrity' meaning he had the power to nominate housemates for the first eviction. Throughout his time in the house, Spence survived three evictions, however he was evicted two days before the final.
Beginning on 1 February 2015, Spence took part in the second series of reality programme The Jump and was eliminated on Day 2.