METAP1

METAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Identifiers
Aliases	METAP1, MAP1A, MetAP1A, methionyl aminopeptidase 1
External IDs	OMIM: 610151 MGI: 1922874 HomoloGene: 6488 GeneCards: METAP1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	99,062,813 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	138,195,276 bp
RNA expression pattern
	Top expressed in
	endometrium; ; rectum; ; urinary bladder; ; hair follicle; ; oral cavity; ; ascending aorta; ; right ventricle; ; thymus; ; smooth muscle tissue; ; corpus epididymis;
	Top expressed in
	primitive streak; ; lens; ; vastus lateralis muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; hair follicle; ; crypt of lieberkuhn of small intestine; ; digastric muscle; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; aminopeptidase activity; metalloexopeptidase activity; hydrolase activity; metal ion binding;
Cellular component	cytosol; cytoplasm;
Biological process	peptidyl-methionine modification; platelet aggregation; N-terminal protein amino acid modification; regulation of translation; proteolysis; regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23173
	75624
	ENSG00000164024
	ENSMUSG00000005813
	P53582
	Q8BP48
	NM_015143
	NM_175224
	NP_055958
	NP_780433
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.^[5]^[6]^[7] Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164024 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005813 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H; et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett. 9 (4): 295–303. doi:10.2174/0929866023408607. PMID 12144506.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "Entrez Gene: METAP1 methionyl aminopeptidase 1".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading