It is a basic dodgeball game with sheer simplicity aimed at a very young audience. The game starts in a specially designed arena, where monsters are lined up like in actual dodgeball and throw laugh balls at each other. There are a total of seven arenas and other bonus stages and mini-games which will be unlocked as the game progresses.
As seen in the movie, the monsters of Monsters, Inc. need to come up with another source of power for their worlds. So they gather their power from kid's laughter by throwing laugh balls at each other and each monster will react differently upon contact. The ultimate goal is to knock off your opponent and fill the laughter canister with children's laughter first. There are a total of 13 monsters among which a player can choose among five to start with. More playable monsters and stages will be unlocked as the game progresses in single-player mode. Each arena is based on a scene from the movie and has five different objectives, like obtaining the most points from pure hits, hitting targets, holding on a special ball longest and more. Only after completing them the player can move on to the next arena. Also, there are different types of balls which are fast, slow, sticky and explosive. The game has both single-player mode and multi-player mode with up to four players. In both modes the winner is the first monster to knock off the opponents.