Organic cation transport proteins

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An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are members of the solute carrier family, subfamily 22. This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier proteins than the organic anion transporters.

Proteins[edit]

Abbreviation Protein name Location Transported solute(s) Associated disorder(s)
SLC22A1 Solute carrier family 22 member 1 Liver, Brain (Cerebellum)
SLC22A2 Solute carrier family 22 member 2 Primarily in kidney, also in brain
SLC22A3 Solute carrier family 22 member 3 Brain and kidney Histamine Dopamine Serotonin Norepinephrine MPP+
SLC22A4 Solute carrier family 22 member 4 Sodium ion and Ergothioneine
SLC22A5 Solute carrier family 22 member 5 Primary carnitine deficiency
SLC22A6 Solute carrier family 22 member 6
SLC22A7 Solute carrier family 22 member 7
SLC22A8 Solute carrier family 22 member 8
SLC22A9 Solute carrier family 22 member 9
SLC22A10 Solute carrier family 22 member 10
SLC22A11 Solute carrier family 22 member 11
SLC22A12 Solute carrier family 22 member 12 Kidney Uric acid Hyperuricemia and hypouricemia
SLC22A13 Solute carrier family 22 member 13
SLC22A14 Solute carrier family 22 member 14
SLC22A15 Solute carrier family 22 member 15
SLC22A16 Solute carrier family 22 member 16
SLC22A17 Solute carrier family 22 member 17
SLC22A18 Solute carrier family 22 member 18 Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer
SLC22A19 Solute carrier family 22 member 19
SLC22A20 Solute carrier family 22 member 20

References[edit]