SLC22A11

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Solute carrier family 22 (organic anion/urate transporter), member 11
Identifiers
Symbols SLC22A11 ; OAT4; hOAT4
External IDs OMIM607097 HomoloGene81863 GeneCards: SLC22A11 Gene
RNA expression pattern
PBB GE SLC22A11 220100 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55867 n/a
Ensembl ENSG00000168065 n/a
UniProt Q9NSA0 n/a
RefSeq (mRNA) NM_018484 n/a
RefSeq (protein) NP_060954 n/a
Location (UCSC) Chr 11:
64.32 – 64.34 Mb
n/a
PubMed search [1] n/a

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.[1][2][3][4]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.[4]

See also[edit]

References[edit]

  1. ^ Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem 275 (6): 4507–12. doi:10.1074/jbc.275.6.4507. PMID 10660625. 
  2. ^ Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633. 
  3. ^ Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol 18 (2): 430–9. doi:10.1681/ASN.2006040415. PMID 17229912. 
  4. ^ a b "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.