SLC22A2

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Solute carrier family 22 (organic cation transporter), member 2
Identifiers
Symbols SLC22A2 ; OCT2
External IDs OMIM602608 MGI1335072 HomoloGene68293 ChEMBL: 1743122 GeneCards: SLC22A2 Gene
RNA expression pattern
PBB GE SLC22A2 207429 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6582 20518
Ensembl ENSG00000112499 ENSMUSG00000040966
UniProt O15244 O70577
RefSeq (mRNA) NM_003058 NM_013667
RefSeq (protein) NP_003049 NP_038695
Location (UCSC) Chr 6:
160.59 – 160.7 Mb
Chr 17:
12.58 – 12.63 Mb
PubMed search [1] [2]

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[2]

See also[edit]

References[edit]

  1. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3-4): 198–200. doi:10.1159/000134720. PMID 9605850. 
  2. ^ a b "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.