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Solute carrier family 22 (organic cation transporter), member 2
Symbols SLC22A2 ; OCT2
External IDs OMIM602608 MGI1335072 HomoloGene68293 ChEMBL: 1743122 GeneCards: SLC22A2 Gene
RNA expression pattern
PBB GE SLC22A2 207429 at tn.png
More reference expression data
Species Human Mouse
Entrez 6582 20518
Ensembl ENSG00000112499 ENSMUSG00000040966
UniProt O15244 O70577
RefSeq (mRNA) NM_003058 NM_013667
RefSeq (protein) NP_003049 NP_038695
Location (UCSC) Chr 6:
160.59 – 160.7 Mb
Chr 17:
12.58 – 12.63 Mb
PubMed search [1] [2]

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[2]

See also[edit]


  1. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3-4): 198–200. doi:10.1159/000134720. PMID 9605850. 
  2. ^ a b "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.