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Pitrilysin metallopeptidase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PITRM1 ; MP1; PreP
External IDs MGI1916867 HomoloGene5742 GeneCards: PITRM1 Gene
RNA expression pattern
PBB GE PITRM1 205273 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10531 69617
Ensembl ENSG00000107959 ENSMUSG00000021193
UniProt Q5JRX3 Q8K411
RefSeq (mRNA) NM_001242307 NM_145131
RefSeq (protein) NP_001229236 NP_660113
Location (UCSC) Chr 10:
3.14 – 3.17 Mb
Chr 13:
6.55 – 6.58 Mb
PubMed search [1] [2]

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene.[1][2][3][4] It is also sometimes called metalloprotease 1 (MP1; ).

Model organisms[edit]

Model organisms have been used in the study of PITRM1 function. A conditional knockout mouse line called Pitrm1tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]


  1. ^ Marusov EV (Jul 1977). "[Ecological sterotypes of defensive behavior in fish under the action of chemical danger signals]". Nauchnye Doki Vyss Shkoly Biol Nauki (8): 67–9. PMID 1036083. 
  2. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851. 
  3. ^ Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M, Glaser E (Sep 2006). "Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP". J Biol Chem 281 (39): 29096–104. doi:10.1074/jbc.M602532200. PMID 16849325. 
  4. ^ "Entrez Gene: PITRM1 pitrilysin metallopeptidase 1". 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]