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Pitrilysin metallopeptidase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PITRM1 ; MP1; PreP
External IDs MGI1916867 HomoloGene5742 GeneCards: PITRM1 Gene
RNA expression pattern
PBB GE PITRM1 205273 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10531 69617
Ensembl ENSG00000107959 ENSMUSG00000021193
UniProt Q5JRX3 Q8K411
RefSeq (mRNA) NM_001242307 NM_145131
RefSeq (protein) NP_001229236 NP_660113
Location (UCSC) Chr 10:
3.14 – 3.17 Mb
Chr 13:
6.55 – 6.58 Mb
PubMed search [1] [2]

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene.[1][2][3][4] It is also sometimes called metalloprotease 1 (MP1; ).


  1. ^ Marusov EV (Jul 1977). "[Ecological sterotypes of defensive behavior in fish under the action of chemical danger signals]". Nauchnye Doki Vyss Shkoly Biol Nauki (8): 67–9. PMID 1036083. 
  2. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851. 
  3. ^ Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M, Glaser E (Sep 2006). "Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP". J Biol Chem 281 (39): 29096–104. doi:10.1074/jbc.M602532200. PMID 16849325. 
  4. ^ "Entrez Gene: PITRM1 pitrilysin metallopeptidase 1". 

Further reading[edit]