Sean O'Brien Strub (born 1958) is a writer and activist who is the director of The Sero Project (www.theseroproject.com), a national network of people with HIV combating stigma and injustice. He founded POZ magazine and POZ en Español, (for people impacted by HIV/AIDS), Mamm (for women impacted by breast cancer), Real Health (an African-American health magazine) and Milford Magazine (a regional title distributed in the Delaware River Highlands area of northeast Pennsylvania).
He is a long-term AIDS survivor  and has been an outspoken advocate for the self-empowerment movement for people with HIV/AIDS. In 2009 he was president of Cable Positive, the cable and telecommunications' industry's AIDS response. From 2010 to 2012 he served on the board of directors of the Amsterdam-based Global Network of People Living with HIV/AIDS (GNP+) and was co-chair of their North American regional affiliate. He has been a leader in combating HIV-related criminalization and in 2010 launched the Positive Justice Project with the Center for HIV Law & Policy.
In 1990, he ran for the U.S. House of Representatives to represent New York's 22nd congressional district. He was the first openly HIV+ candidate for federal office in the U.S. and received 46% of the Democratic primary vote. He was a long-time member of ACT UP New York. Strub produced an off-Broadway play, The Night Larry Kramer Kissed Me, written by and starring David Drake, in 1992.
Strub co-authored Rating America's Corporate Conscience (Addison-Wesley, 1985), a guide to corporate social responsibility, with Steve Lydenberg and Alice Tepper Marlin and Cracking the Corporate Closet (HarperBusiness, 1995) with Daniel B. Baker and Bill Henning. His memoir, Body Counts: A Memoir of Politics, Sex, AIDS and Survival (Scribner) will be published in January, 2014.
He is an inaugural member of the WikiQueer Global Advisory Board.
Strub was one of the first people on the scene of the murder of John Lennon in December 1980. Jeanne Downey, a TV reporter with Channel 2 - CBS interviewed Mr. Strub within an hour after Lennon had been killed. "Was there any kind of an exchange, do you know," Downey asked, "between Lennon and the suspect?" To that, Strub replied: "That's what the doorman said that there had been some sort of altercation or argument."
In 1981 Strub got playwright Tennessee Williams to sign the first fundraising letter for the Human Rights Campaign Fund, a then newly formed political action committee which grew to become the largest organization in the U.S. advocating for LGBT equality. In 1989 Strub asked pop artist Keith Haring to create a logo and poster to launch National Coming Out Day, now also a part of the Human Rights Campaign. Strub was one of the AIDS activists who put a giant condom over then-US Senator Jesse Helms' suburban Washington home in 1991.
- Sean O. Strub, Bio, retrieved 2008-09-02
- In a Changing Era, a Reminder of AIDS from the New York Times October 11, 2009
- What's Wrong With The AIDS Movement from DIRELAND December 1, 2005
- "''Rachel Maddow Introduces Sean Strub''". Youtube.com. 2009-04-10. Retrieved 2013-12-05.
- Fighting AIDS, Peer to Peer from New York Times May 11, 2009
- Sender, Katherine (2005), Business, not politics, Columbia University Press, p. 255, ISBN 0-231-12734-0
- Theatre On Stage and Off from New York Times March 26, 1993
- Endean, Steve (2006), Bringing Lesbian and Gay Rights Into The Mainstream: Twenty Years of Progress, Routledge, p. 241, ISBN 1-56023-526-8
- D'Emilio, John (2002), The World Turned: Essays on Gay History, Politics and Culture, Duke University Press, p. 193, ISBN 978-0-8223-2930-5
- Vaid, Urvashi (1995), Virtual Equality, Simon&Schuster, p. 226, ISBN 0-385-47298-6
- Sherman, Phillip (1994), Uncommon Heroes: A Celebration of Heroes and Role Models for Gay and Lesbian Americans, Fletcher Press, p. 257
- Levin, Sue (1998), In The Pink, The Making of Successful Gay and Lesbian-owned Businesses, Routledge, p. 96, ISBN 0-7890-0579-4
- Badgett, M.V. Lee (2003), Money, Myths and Change: The Economic Lives of Lesbians and Gay Men, University of Chicago Press, p. 114, ISBN 0-226-03401-1
- Bailey, Robert W. (1999), Gay Politics, Urban Politics: Identity and Economics in the Urban Setting, Columbia University Press, p. xii, ISBN 0-231-09663-1
- Gluckman, Amy (1997), Homo Economics: Capitalism, Community, and Lesbian and Gay Life, Routledge, p. 12, ISBN 0-415-91379-9
- Chasin, Alexandra (2001), Selling Out: The Gay and Lesbian Movement Goes to Market, Palgrave Macmillan, p. 268, ISBN 0-312-23926-2
- A Village Home for a Man About Town from the New York Times October 21, 2008
- A Tour of Milford, Pennsylvania from Travel+Leisure March, 2009
- "WikiQueer:Global Advisory Board". WikiQueer. Retrieved March 27, 2013.
- Clendinen, Dudley (2001), Out For Good, Simon&Schuster, p. 440, ISBN 0684867435
- Sears, James Thomas (2005), Youth, Education and Sexualities, Greenwood Publishing Group, p. 583, ISBN 0-313-32748-3
- Condomizing Jesse Helms from Huffington PostJuly 17, 2008