Slow-reacting substance of anaphylaxis

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LTC4
LTD4
LTE4

The Slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2]. Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.[citation needed]

[edit] References

  1. ^ "Dorland's Medical Dictionary". http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_s_27zPzhtm. Retrieved December 15, 2006. 
  2. ^ Howard R. Morris, Graham W. Taylor, Priscilla J. Piper, John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". http://www.nature.com/nature/journal/v285/n5760/abs/285104a0.html. Retrieved December 15, 2006. 

[edit] External links
Precursor
Prostanoids
Precursor
Active
D/J
E/F
I
A2 · B2
Leukotrienes (LT)
Precursor
Initial
A4 · B4
SRS-A
C4 · D4 · E4
Nonclassic
By function

bronchoconstriction (PGD2, TXA2, LTC4, LTD4, LTE4)

vasoconstriction (PGF2α, TXA2, TXB2) · vasodilation (PGE2, PGI2, LTC4, LTD4, LTE4)

platelets: induce (TXA2) inhibit (PGD2, PGI2) · leukocytes: induce (TXA2, LTB4) inhibit (PGD2, PGE2)

fever stimulation: (PGE2)

labor stimulation: (PGE2 (Dinoprostone), PGF2α (Dinoprost))

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)


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