George H. Park, a local builder-contractor, began construction in the Italianate style in 1884 at the behest of Charles Baker. The hotel opened in 1885 under the name, Baker Hotel, although Baker had already sold the building to Stephen Smeede for $12,000. In 1892, Smeede improved the property and changed the name to Hotel Eugene. It was again changed to Hotel Smeede in 1907, and in 1914 it became the Smeede Hotel.
The hotel remained in continuous operation until the early 1970s. The Eugene Renewel Agency purchased the three-story structure and began renovations in 1971 for commercial office space. In 1973 the Lane County Pioneer Museum applied to place the building on the National Register of Historic Places.
See also 
- National Register of Historic Places listings in Lane County, Oregon
- Walling, Illustrated History of Lane County (Portland, 1884), p. 441.