The son of William Jenyns, he was born at Wolverhampton before 1450. He settled in London, became a prominent member of the Merchant Taylors' Company, and served the office of Master in 1489. He grew rich, and was an alderman of the city of London. He became Sheriff of London in 1498, and was chosen Lord Mayor in 1508. He was present at the funeral of Henry VII, and was knighted at the coronation of Henry VIII.
Jenyns obtained a license, 22 September 1512, to found the Wolverhampton grammar school, and applied the Rushocke estate to its maintenance. The school remained under the control of the Merchant Taylors' Company until 1766.
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