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Tolloid-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TLL1 ; ASD6; TLL
External IDs OMIM606742 MGI106923 HomoloGene49202 GeneCards: TLL1 Gene
EC number 3.4.24.-
Species Human Mouse
Entrez 7092 21892
Ensembl ENSG00000038295 ENSMUSG00000053626
UniProt O43897 Q62381
RefSeq (mRNA) NM_001204760 NM_009390
RefSeq (protein) NP_001191689 NP_033416
Location (UCSC) Chr 4:
166.79 – 167.03 Mb
Chr 8:
64.01 – 64.21 Mb
PubMed search [1] [2]

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.[1][2]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.[2]


  1. ^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. 
  2. ^ a b "Entrez Gene: TLL1 tolloid-like 1". 

Further reading[edit]