There is evidence of a port at Uphill since Roman times, probably for the export of lead from the Mendip Hills. It continued as a small landing stage for many centuries including the import of coal and iron and the export of local produce.
The Bristol to Exeter railway line runs through a steep cutting between Uphill and nearby Bleadon. This cutting is spanned by a high brick bridge known as "Devil's Bridge" and designed by Isambard Kingdom Brunel. The former Bleadon and Uphill railway station served the village from 1871 until 1964.
Uphill is situated at the south end of Weston Bay, where the River Axe flows into the Bristol Channel, and was once a busy port. The Mendip Way long-distance footpath has its western trailhead at Uphill near the wharf.
The village is dominated on its southern side by a large hill, the southern slope of which and the quarry at its western end form the Uphill Cliff Site of Special Scientific Interest, notable for its species-rich calcareous grassland. It consists of species-rich calcareous grassland and rock-face situated on Carboniferous Limestone. Steeper banks and knolls in the grassland have a flora which includes orchids Somerset Hair Grass Koeleria vallesiana, and Honewort Trinia glauca and the Goldilocks Aster linosyris along with several species of butterfly and Weevil (Curculionoidea).
A tower on the hill is the remains of a 14th-century windmill.
The present day Church of St Nicholas is situated on lower ground towards the north end of the village.
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