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{{Drugbox
{{Drugbox
| verifiedrevid = 443927967
| verifiedrevid = 443927967
⚫
| type = combo


<!--Combo data-->
<!--Combo data-->
⚫
| type = combo
| component1 = Clindamycin phosphate
| component1 = Clindamycin phosphate
| class1 = [[Antibiotic]]
| class1 = [[Antibiotic]]
| component2 = Tretinoin
| component2 = Tretinoin
| class2 = [[Retinoid|Topical retinoid]]
| class2 = [[Retinoid|Topical retinoid]]
| component3 =
| class3 =
| component4 = <!-- Drugname, automatically linked -->
| class4 = <!-- Group, manual link using [[..|..]] -->


<!--Clinical data-->
<!--Clinical data-->
| tradename = Ziana, Veltin, Acnatac, others
| tradename = Ziana, others
| MedlinePlus = a609005
| MedlinePlus = a609005
| licence_EU = <!-- EMEA requires brand name -->
| licence_US = Ziana
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = C
| pregnancy_category =
| pregnancy_category =
⚫
| routes_of_administration = [[Topical]]
| ATC_prefix = D10
| ATC_suffix = AD51
⚫
| ATC_supplemental =

| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US =
| legal_US =
| legal_status = Rx
| legal_status = Rx-only
| dependency_liability =
⚫
| routes_of_administration = [[Topical]]


<!--Identifiers-->
<!--Identifiers-->
| CAS_number = 337954-93-5
| CAS_number = 337954-93-5
| ATC_prefix = D10
| PubChem =
| ATC_suffix = AD51
| DrugBank =
⚫
| ATC_supplemental =
| PubChem =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| KEGG = D11084
| KEGG = D11084
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID =
| ChemSpiderID =


<!--Chemical data-->
<!--Chemical data-->
}}
}}


'''Clindamycin/tretinoin''' is a [[Topical gels|topical gel]] used in the treatment of [[acne]]. The two active ingredients are the antibiotic [[clindamycin]] phosphate (1.2%) and [[tretinoin]] (0.025%), a [[retinoid]].<ref>{{cite web |url=http://www.ziana.com |title=Ziana Gel |access-date=2008-11-16}}</ref> The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.<ref>{{Cite web|title=BNF is only available in the UK|url=https://www.nice.org.uk/bnf-uk-only|access-date=2021-10-05|website=NICE}}</ref> The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.<ref>{{cite journal | vauthors = Zasada M, Budzisz E | title = Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments | journal = Postepy Dermatologii I Alergologii | volume = 36 | issue = 4 | pages = 392–397 | date = August 2019 | pmid = 31616211 | pmc = 6791161 | doi = 10.5114/ada.2019.87443 }}</ref> The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.<ref>{{cite web |url=http://www.medicis.com/products/pi/pi_ziana.pdf |title=ZIANA Prescribing Information |access-date=2008-11-15 |archive-url=https://web.archive.org/web/20070617182911/http://www.medicis.com/products/pi/pi_ziana.pdf |archive-date=2007-06-17 |url-status=dead }}</ref> Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or [[colitis]]. Sun exposure while using this preparation can cause skin irritation.<ref>{{Cite journal |last=Kurokawa |first=Ichiro |date=2016-05-19 |title=Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris. |doi=10.3410/f.726161029.793518600 |doi-access=free }}</ref>
'''Clindamycin/tretinoin''' is a [[Topical gels|topical gel]] used in the treatment of [[acne]]. The two active ingredients are the antibiotic [[clindamycin]] phosphate (1.2%) and [[tretinoin]] (0.025%), a [[retinoid]].<ref>{{cite web |url=http://www.ziana.com |title=Ziana Gel |access-date=2008-11-16}}</ref> The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.<ref>{{Cite web|title=BNF is only available in the UK|url=https://www.nice.org.uk/bnf-uk-only|access-date=2021-10-05|website=NICE}}</ref> The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.<ref>{{cite journal | vauthors = Zasada M, Budzisz E | title = Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments | journal = Postepy Dermatologii I Alergologii | volume = 36 | issue = 4 | pages = 392–397 | date = August 2019 | pmid = 31616211 | pmc = 6791161 | doi = 10.5114/ada.2019.87443 }}</ref> The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.<ref>{{cite web |url=http://www.medicis.com/products/pi/pi_ziana.pdf |title=Ziana Prescribing Information |access-date=2008-11-15 |archive-url=https://web.archive.org/web/20070617182911/http://www.medicis.com/products/pi/pi_ziana.pdf |archive-date=2007-06-17 |url-status=dead }}</ref> Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or [[colitis]]. Sun exposure while using this preparation can cause skin irritation.<ref>{{Cite journal |last=Kurokawa |first=Ichiro |date=2016-05-19 |title=Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris. |doi=10.3410/f.726161029.793518600 |doi-access=free }}</ref>


== Citations ==
== Citations ==
{{reflist}}
{{reflist}}

== External links ==
* [http://www.ziana.com Official Website]


{{Acne Agents}}
{{Acne Agents}}
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[[Category:Anti-acne preparations]]
[[Category:Anti-acne preparations]]
[[Category:Combination drugs]]
[[Category:Combination drugs]]



{{dermatologic-drug-stub}}
{{dermatologic-drug-stub}}

Revision as of 06:46, 20 June 2024

Clindamycin/tretinoin
Combination of
Clindamycin phosphateAntibiotic
TretinoinTopical retinoid
Clinical data
Trade namesZiana, others
MedlinePlusa609005
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
KEGG
  (verify)

Clindamycin/tretinoin is a topical gel used in the treatment of acne. The two active ingredients are the antibiotic clindamycin phosphate (1.2%) and tretinoin (0.025%), a retinoid.[1] The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.[2] The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.[3] The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.[4] Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or colitis. Sun exposure while using this preparation can cause skin irritation.[5]

Citations

  1. ^ "Ziana Gel". Retrieved 2008-11-16.
  2. ^ "BNF is only available in the UK". NICE. Retrieved 2021-10-05.
  3. ^ Zasada M, Budzisz E (August 2019). "Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments". Postepy Dermatologii I Alergologii. 36 (4): 392–397. doi:10.5114/ada.2019.87443. PMC 6791161. PMID 31616211.
  4. ^ "Ziana Prescribing Information" (PDF). Archived from the original (PDF) on 2007-06-17. Retrieved 2008-11-15.
  5. ^ Kurokawa, Ichiro (2016-05-19). "Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris". doi:10.3410/f.726161029.793518600. {{cite journal}}: Cite journal requires |journal= (help)


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