Orotic acid

Orotic acid

Clinical data
ATC code	none
Identifiers
IUPAC name 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
CAS Number	65-86-1
PubChem CID	967
DrugBank	EXPT02447
CompTox Dashboard (EPA)	DTXSID0025814
ECHA InfoCard	100.000.563
Chemical and physical data
Formula	C5H4N2O4
Molar mass	156.10 g/mol g·mol−1
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Orotic acid is a heterocyclic compound and an acid; it is also known as pyrimidinecarboxylic acid. It was once believed to be part of the vitamin B complex and was called vitamin B₁₃, but it is now known that it is not a vitamin but is instead manufactured in the body by intestinal flora.

Its salts, known as orotates, are sometimes used as mineral carriers in some dietary supplements, to increase their bioavailability. Lithium orotate is the most frequently used in this manner.

Orotic Acid diseases

A buildup of orotic acid can lead to orotic aciduria.

In ornithine transcarbamoylase deficiency, a disorder of the urea cycle, excess carbamoyl phospate is converted into orotic acid. This typically leads to increased urinary orotic acid excretion.

See also

• Pyrimidine biosynthesis

References

• Orotic Acid antagonist: "6-Uracilsulfonic Acid, a Sulronic Acid Analog of Orotic Acid" Sheldon B. Greenbaum, J. Am. Chem. Soc., 1954, 76 (23), pp 6052–6054

External links

• Orotic+Acid at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview at ggc.org
• Overview at greatvistachemicals.com
• Overview of Potential Metabolic Antagonists