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{{PBB|geneid=8655}}
{{PBB|geneid=8655}}
'''Dynein light chain 1, cytoplasmic''' is a [[protein]] that in humans is encoded by the ''DYNLL1'' [[gene]].<ref name="pmid8628263">{{cite journal | author = Dick T, Ray K, Salz HK, Chia W | title = Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster | journal = Mol Cell Biol | volume = 16 | issue = 5 | pages = 1966–77 |date=June 1996 | pmid = 8628263 | pmc = 231184 | doi = }}</ref><ref name="pmid8864115">{{cite journal | author = Jaffrey SR, Snyder SH | title = PIN: an associated protein inhibitor of neuronal nitric oxide synthase | journal = Science | volume = 274 | issue = 5288 | pages = 774–7 |date=December 1996 | pmid = 8864115 | pmc = | doi =10.1126/science.274.5288.774 }}</ref><ref name="pmid16260502">{{cite journal | author = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=November 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8655| accessdate = }}</ref>
'''Dynein light chain 1, cytoplasmic''' is a [[protein]] that in humans is encoded by the ''DYNLL1'' [[gene]].<ref name="pmid8628263">{{cite journal | vauthors = Dick T, Ray K, Salz HK, Chia W | title = Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster | journal = Molecular and Cellular Biology | volume = 16 | issue = 5 | pages = 1966–77 | date = May 1996 | pmid = 8628263 | pmc = 231184 | doi = }}</ref><ref name="pmid8864115">{{cite journal | vauthors = Jaffrey SR, Snyder SH | title = PIN: an associated protein inhibitor of neuronal nitric oxide synthase | journal = Science | volume = 274 | issue = 5288 | pages = 774–7 | date = Nov 1996 | pmid = 8864115 | pmc = | doi = 10.1126/science.274.5288.774 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = The Journal of Cell Biology | volume = 171 | issue = 3 | pages = 411–3 | date = Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8655| accessdate = }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
⚫
| summary_text = Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.<ref name="entrez"/>
}}


⚫
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.<ref name="entrez"/>
==Interactions==
DYNLL1 has been shown to [[Protein-protein interaction|interact]] with [[DLGAP1]],<ref name=pmid10844022>{{cite journal |last=Naisbitt |first=S |authorlink= |author2=Valtschanoff J |author3=Allison D W |author4=Sala C |author5=Kim E |author6=Craig A M |author7=Weinberg R J |author8=Sheng M |date=June 2000 |title=Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein |journal=J. Neurosci. |volume=20 |issue=12 |pages=4524–34 |publisher= |location = UNITED STATES| issn = 0270-6474| pmid = 10844022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MYO5A]],<ref name=pmid10844022/> [[DYNC1I1]],<ref name=pmid12475239>{{cite journal |last=Diefenbach |first=Russell J |authorlink= |author2=Diefenbach Eve |author3=Douglas Mark W |author4=Cunningham Anthony L |date=December 2002 |title=The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 |journal=Biochemistry |volume=41 |issue=50 |pages=14906–15 |publisher= |location = United States| issn = 0006-2960| pmid = 12475239 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1021/bi026417u }}</ref> [[BCL2L11]],<ref name=pmid14561217>{{cite journal |last=Day |first=Catherine L |authorlink= |author2=Puthalakath Hamsa |author3=Skea Gretchen |author4=Strasser Andreas |author5=Barsukov Igor |author6=Lian Lu-Yun |author7=Huang David C S |author8=Hinds Mark G |date=February 2004 |title=Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands |journal=Biochem. J. |volume=377 |issue=Pt 3 |pages=597–605 |publisher= |location = England| issn = | pmid = 14561217 |doi = 10.1042/BJ20031251 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223895 }}</ref><ref name=pmid15193260>{{cite journal |last=Vadlamudi |first=Ratna K |authorlink= |author2=Bagheri-Yarmand Rozita |author3=Yang Zhibo |author4=Balasenthil Seetharaman |author5=Nguyen Diep |author6=Sahin Aysegul A |author7=den Hollander Petra |author8=Kumar Rakesh |date=June 2004 |title=Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes |journal=Cancer Cell |volume=5 |issue=6 |pages=575–85 |publisher= |location = United States| issn = 1535-6108| pmid = 15193260 |doi = 10.1016/j.ccr.2004.05.022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[NRF1]],<ref name=pmid11069771>{{cite journal |last=Herzig |first=R P |authorlink= |author2=Andersson U |author3=Scarpulla R C |date=December 2000 |title=Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila |journal=J. Cell. Sci. |volume=113 Pt 23 |issue= |pages=4263–73 |publisher= |location = ENGLAND| issn = 0021-9533| pmid = 11069771 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[IκBα]],<ref name=pmid9372968>{{cite journal |last=Crépieux |first=P |authorlink= |author2=Kwon H |author3=Leclerc N |author4=Spencer W |author5=Richard S |author6=Lin R |author7=Hiscott J |date=December 1997 |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain |journal=Mol. Cell. Biol. |volume=17 |issue=12 |pages=7375–85 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9372968 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=232593 }}</ref> [[PAK1]],<ref name=pmid15193260/> [[DLG4]]<ref name=pmid10844022/> and [[TP53BP1]].<ref name=pmid15611139>{{cite journal |last=Lo |first=Kevin W-H |authorlink= |author2=Kan Ho-Man |author3=Chan Ling-Nga |author4=Xu Wei-Guang |author5=Wang Ke-Peng |author6=Wu Zhenguo |author7=Sheng Morgan |author8=Zhang Mingjie |date=March 2005 |title=The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation |journal=J. Biol. Chem. |volume=280 |issue=9 |pages=8172–9 |publisher= |location = United States| issn = 0021-9258| pmid = 15611139 |doi = 10.1074/jbc.M411408200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
== Interactions ==

DYNLL1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[BCL2L11]],<ref name = pmid14561217>{{cite journal | vauthors = Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG | title = Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands | journal = The Biochemical Journal | volume = 377 | issue = Pt 3 | pages = 597–605 | date = Feb 2004 | pmid = 14561217 | pmc = 1223895 | doi = 10.1042/BJ20031251 }}</ref><ref name = pmid15193260>{{cite journal | vauthors = Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R | title = Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes | journal = Cancer Cell | volume = 5 | issue = 6 | pages = 575–85 | date = Jun 2004 | pmid = 15193260 | doi = 10.1016/j.ccr.2004.05.022 }}</ref>
* [[DLG4]]<ref name = pmid10844022/>
* [[DLGAP1]],<ref name = pmid10844022>{{cite journal | vauthors = Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M | title = Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein | journal = The Journal of Neuroscience | volume = 20 | issue = 12 | pages = 4524–34 | date = Jun 2000 | pmid = 10844022 | doi = }}</ref>
* [[DYNC1I1]],<ref name = pmid12475239>{{cite journal | vauthors = Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL | title = The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 | journal = Biochemistry | volume = 41 | issue = 50 | pages = 14906–15 | date = Dec 2002 | pmid = 12475239 | doi = }}</ref>
* [[IκBα]],<ref name = pmid9372968>{{cite journal | vauthors = Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J | title = I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7375–85 | date = Dec 1997 | pmid = 9372968 | pmc = 232593 | doi = }}</ref>
* [[MYO5A]],<ref name = pmid10844022/>
* [[NRF1]],<ref name = pmid11069771>{{cite journal | vauthors = Herzig RP, Andersson U, Scarpulla RC | title = Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila | journal = Journal of Cell Science | volume = 113 Pt 23 | issue = | pages = 4263–73 | date = Dec 2000 | pmid = 11069771 | doi = }}</ref>
* [[PAK1]],<ref name = pmid15193260/> and
* [[TP53BP1]].<ref name = pmid15611139>{{cite journal | vauthors = Lo KW, Kan HM, Chan LN, Xu WG, Wang KP, Wu Z, Sheng M, Zhang M | title = The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 9 | pages = 8172–9 | date = Mar 2005 | pmid = 15611139 | doi = 10.1074/jbc.M411408200 }}</ref>
{{Div col end}}

== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | date = Sep 1994 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J | title = I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7375–85 | date = Dec 1997 | pmid = 9372968 | pmc = 232593 | doi = }}
| citations =
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 |display-authors=etal}}
* {{cite journal | vauthors = Tochio H, Ohki S, Zhang Q, Li M, Zhang M | title = Solution structure of a protein inhibitor of neuronal nitric oxide synthase | journal = Nature Structural Biology | volume = 5 | issue = 11 | pages = 965–9 | date = Nov 1998 | pmid = 9808041 | doi = 10.1038/2940 }}
*{{cite journal | author=Crépieux P, Kwon H, Leclerc N |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375–85 |year= 1997 |pmid= 9372968 |doi= | pmc=232593 |display-authors=etal}}
* {{cite journal | vauthors = Rodríguez-Crespo I, Straub W, Gavilanes F, Ortiz de Montellano PR | title = Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition | journal = Archives of Biochemistry and Biophysics | volume = 359 | issue = 2 | pages = 297–304 | date = Nov 1998 | pmid = 9808772 | doi = 10.1006/abbi.1998.0928 }}
*{{cite journal | author=Tochio H, Ohki S, Zhang Q |title=Solution structure of a protein inhibitor of neuronal nitric oxide synthase |journal=Nat. Struct. Biol. |volume=5 |issue= 11 |pages= 965–9 |year= 1998 |pmid= 9808041 |doi= 10.1038/2940 |display-authors=etal}}
* {{cite journal | vauthors = Fan JS, Zhang Q, Li M, Tochio H, Yamazaki T, Shimizu M, Zhang M | title = Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme | journal = The Journal of Biological Chemistry | volume = 273 | issue = 50 | pages = 33472–81 | date = Dec 1998 | pmid = 9837926 | doi = 10.1074/jbc.273.50.33472 }}
*{{cite journal | author=Rodríguez-Crespo I, Straub W, Gavilanes F, Ortiz de Montellano PR |title=Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition |journal=Arch. Biochem. Biophys. |volume=359 |issue= 2 |pages= 297–304 |year= 1998 |pmid= 9808772 |doi=10.1006/abbi.1998.0928 }}
* {{cite journal | vauthors = Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A | title = The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex | journal = Molecular Cell | volume = 3 | issue = 3 | pages = 287–96 | date = Mar 1999 | pmid = 10198631 | doi = 10.1016/S1097-2765(00)80456-6 }}
*{{cite journal | author=Fan JS, Zhang Q, Li M |title=Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33472–81 |year= 1999 |pmid= 9837926 |doi=10.1074/jbc.273.50.33472 |display-authors=etal}}
* {{cite journal | vauthors = Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J | title = Structure of the PIN/LC8 dimer with a bound peptide | journal = Nature Structural Biology | volume = 6 | issue = 8 | pages = 735–40 | date = Aug 1999 | pmid = 10426949 | doi = 10.1038/11501 }}
*{{cite journal | author=Puthalakath H, Huang DC, O'Reilly LA |title=The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex |journal=Mol. Cell |volume=3 |issue= 3 |pages= 287–96 |year= 1999 |pmid= 10198631 |doi=10.1016/S1097-2765(00)80456-6 |display-authors=etal}}
* {{cite journal | vauthors = Epstein E, Sela-Brown A, Ringel I, Kilav R, King SM, Benashski SE, Yisraeli JK, Silver J, Naveh-Many T | title = Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules | journal = The Journal of Clinical Investigation | volume = 105 | issue = 4 | pages = 505–12 | date = Feb 2000 | pmid = 10683380 | pmc = 289163 | doi = 10.1172/JCI8557 }}
*{{cite journal | author=Liang J, Jaffrey SR, Guo W |title=Structure of the PIN/LC8 dimer with a bound peptide |journal=Nat. Struct. Biol. |volume=6 |issue= 8 |pages= 735–40 |year= 1999 |pmid= 10426949 |doi= 10.1038/11501 |display-authors=etal}}
* {{cite journal | vauthors = Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M | title = Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein | journal = The Journal of Neuroscience | volume = 20 | issue = 12 | pages = 4524–34 | date = Jun 2000 | pmid = 10844022 | doi = }}
*{{cite journal | author=Epstein E, Sela-Brown A, Ringel I |title=Dynein light chain binding to a 3′-untranslated sequence mediates parathyroid hormone mRNA association with microtubules |journal=J. Clin. Invest. |volume=105 |issue= 4 |pages= 505–12 |year= 2000 |pmid= 10683380 |doi=10.1172/JCI8557 | pmc=289163 |display-authors=etal}}
* {{cite journal | vauthors = Jacob Y, Badrane H, Ceccaldi PE, Tordo N | title = Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein | journal = Journal of Virology | volume = 74 | issue = 21 | pages = 10217–22 | date = Nov 2000 | pmid = 11024152 | pmc = 102062 | doi = 10.1128/JVI.74.21.10217-10222.2000 }}
*{{cite journal | author=Naisbitt S, Valtschanoff J, Allison DW |title=Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein |journal=J. Neurosci. |volume=20 |issue= 12 |pages= 4524–34 |year= 2000 |pmid= 10844022 |doi= |display-authors=etal}}
* {{cite journal | vauthors = Herzig RP, Andersson U, Scarpulla RC | title = Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila | journal = Journal of Cell Science | volume = 113 Pt 23 | issue = | pages = 4263–73 | date = Dec 2000 | pmid = 11069771 | doi = }}
*{{cite journal | author=Jacob Y, Badrane H, Ceccaldi PE, Tordo N |title=Cytoplasmic Dynein LC8 Interacts with Lyssavirus Phosphoprotein |journal=J. Virol. |volume=74 |issue= 21 |pages= 10217–22 |year= 2000 |pmid= 11024152 |doi=10.1128/JVI.74.21.10217-10222.2000 | pmc=102062 }}
* {{cite journal | vauthors = Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T | title = The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase | journal = Genes to Cells | volume = 5 | issue = 11 | pages = 905–911 | date = Nov 2000 | pmid = 11122378 | doi = 10.1046/j.1365-2443.2000.00374.x }}
*{{cite journal | author=Herzig RP, Andersson U, Scarpulla RC |title=Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila |journal=J. Cell. Sci. |volume=113 Pt 23 |issue= |pages= 4263–73 |year= 2001 |pmid= 11069771 |doi= }}
* {{cite journal | vauthors = Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M | title = The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif | journal = The Journal of Biological Chemistry | volume = 276 | issue = 17 | pages = 14059–66 | date = Apr 2001 | pmid = 11148209 | doi = 10.1074/jbc.M010320200 }}
*{{cite journal | author=Haraguchi K, Satoh K, Yanai H |title=The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase |journal=Genes Cells |volume=5 |issue= 11 |pages= 905–911 |year= 2001 |pmid= 11122378 |doi=10.1046/j.1365-2443.2000.00374.x |display-authors=etal}}
* {{cite journal | vauthors = Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P, Sung C, Chao MV | title = Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor | journal = The Journal of Neuroscience | volume = 21 | issue = 3 | pages = RC125 | date = Feb 2001 | pmid = 11157096 | doi = }}
*{{cite journal | author=Lo KW, Naisbitt S, Fan JS |title=The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14059–66 |year= 2001 |pmid= 11148209 |doi= 10.1074/jbc.M010320200 |display-authors=etal}}
* {{cite journal | vauthors = Fan J, Zhang Q, Tochio H, Li M, Zhang M | title = Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain | journal = Journal of Molecular Biology | volume = 306 | issue = 1 | pages = 97–108 | date = Feb 2001 | pmid = 11178896 | doi = 10.1006/jmbi.2000.4374 }}
*{{cite journal | author=Yano H, Lee FS, Kong H |title=Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor |journal=J. Neurosci. |volume=21 |issue= 3 |pages= RC125 |year= 2001 |pmid= 11157096 |doi= |display-authors=etal}}
* {{cite journal | vauthors = Bielli A, Thörnqvist PO, Hendrick AG, Finn R, Fitzgerald K, McCaffrey MW | title = The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1 | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 5 | pages = 1141–53 | date = Mar 2001 | pmid = 11243854 | doi = 10.1006/bbrc.2001.4468 }}
*{{cite journal | author=Fan J, Zhang Q, Tochio H |title=Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain |journal=J. Mol. Biol. |volume=306 |issue= 1 |pages= 97–108 |year= 2001 |pmid= 11178896 |doi= 10.1006/jmbi.2000.4374 |display-authors=etal}}
* {{cite journal | vauthors = Yu J, Yu L, Chen Z, Zheng L, Chen X, Wang X, Ren D, Zhao S | title = Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors | journal = Brain Research. Molecular Brain Research | volume = 99 | issue = 2 | pages = 145–9 | date = Mar 2002 | pmid = 11978406 | doi = 10.1016/S0169-328X(02)00104-3 }}
*{{cite journal | author=Bielli A, Thörnqvist PO, Hendrick AG |title=The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1 |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1141–53 |year= 2001 |pmid= 11243854 |doi= 10.1006/bbrc.2001.4468 |display-authors=etal}}
* {{cite journal | vauthors = Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M | title = Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes | journal = The Journal of Neuroscience | volume = 22 | issue = 13 | pages = 5393–402 | date = Jul 2002 | pmid = 12097491 | doi = 20026552 }}
*{{cite journal | author=Yu J, Yu L, Chen Z |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145–9 |year= 2002 |pmid= 11978406 |doi=10.1016/S0169-328X(02)00104-3 |display-authors=etal}}
*{{cite journal | author=Fuhrmann JC, Kins S, Rostaing P |title=Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5393–402 |year= 2002 |pmid= 12097491 |display-authors=etal}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8655}}
{{PDB Gallery|geneid=8655}}

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Revision as of 17:06, 25 November 2015

Template:PBB Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.[1][2][3][4]

Function

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.[4]

Interactions

DYNLL1 has been shown to interact with:

References

  1. ^ Dick T, Ray K, Salz HK, Chia W (May 1996). "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster". Molecular and Cellular Biology. 16 (5): 1966–77. PMC 231184. PMID 8628263.
  2. ^ Jaffrey SR, Snyder SH (Nov 1996). "PIN: an associated protein inhibitor of neuronal nitric oxide synthase". Science. 274 (5288): 774–7. doi:10.1126/science.274.5288.774. PMID 8864115.
  3. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". The Journal of Cell Biology. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  4. ^ a b "Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1".
  5. ^ Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (Feb 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
  6. ^ a b Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R (Jun 2004). "Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell. 5 (6): 575–85. doi:10.1016/j.ccr.2004.05.022. PMID 15193260.
  7. ^ a b c Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (Jun 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–34. PMID 10844022.
  8. ^ Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. PMID 12475239.
  9. ^ Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J (Dec 1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain". Molecular and Cellular Biology. 17 (12): 7375–85. PMC 232593. PMID 9372968.
  10. ^ Herzig RP, Andersson U, Scarpulla RC (Dec 2000). "Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila". Journal of Cell Science. 113 Pt 23: 4263–73. PMID 11069771.
  11. ^ Lo KW, Kan HM, Chan LN, Xu WG, Wang KP, Wu Z, Sheng M, Zhang M (Mar 2005). "The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation". The Journal of Biological Chemistry. 280 (9): 8172–9. doi:10.1074/jbc.M411408200. PMID 15611139.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J (Dec 1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain". Molecular and Cellular Biology. 17 (12): 7375–85. PMC 232593. PMID 9372968.
  • Tochio H, Ohki S, Zhang Q, Li M, Zhang M (Nov 1998). "Solution structure of a protein inhibitor of neuronal nitric oxide synthase". Nature Structural Biology. 5 (11): 965–9. doi:10.1038/2940. PMID 9808041.
  • Rodríguez-Crespo I, Straub W, Gavilanes F, Ortiz de Montellano PR (Nov 1998). "Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition". Archives of Biochemistry and Biophysics. 359 (2): 297–304. doi:10.1006/abbi.1998.0928. PMID 9808772.
  • Fan JS, Zhang Q, Li M, Tochio H, Yamazaki T, Shimizu M, Zhang M (Dec 1998). "Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme". The Journal of Biological Chemistry. 273 (50): 33472–81. doi:10.1074/jbc.273.50.33472. PMID 9837926.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A (Mar 1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex". Molecular Cell. 3 (3): 287–96. doi:10.1016/S1097-2765(00)80456-6. PMID 10198631.
  • Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J (Aug 1999). "Structure of the PIN/LC8 dimer with a bound peptide". Nature Structural Biology. 6 (8): 735–40. doi:10.1038/11501. PMID 10426949.
  • Epstein E, Sela-Brown A, Ringel I, Kilav R, King SM, Benashski SE, Yisraeli JK, Silver J, Naveh-Many T (Feb 2000). "Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules". The Journal of Clinical Investigation. 105 (4): 505–12. doi:10.1172/JCI8557. PMC 289163. PMID 10683380.
  • Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (Jun 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–34. PMID 10844022.
  • Jacob Y, Badrane H, Ceccaldi PE, Tordo N (Nov 2000). "Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein". Journal of Virology. 74 (21): 10217–22. doi:10.1128/JVI.74.21.10217-10222.2000. PMC 102062. PMID 11024152.
  • Herzig RP, Andersson U, Scarpulla RC (Dec 2000). "Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila". Journal of Cell Science. 113 Pt 23: 4263–73. PMID 11069771.
  • Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T (Nov 2000). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes to Cells. 5 (11): 905–911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378.
  • Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P, Sung C, Chao MV (Feb 2001). "Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor". The Journal of Neuroscience. 21 (3): RC125. PMID 11157096.
  • Fan J, Zhang Q, Tochio H, Li M, Zhang M (Feb 2001). "Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain". Journal of Molecular Biology. 306 (1): 97–108. doi:10.1006/jmbi.2000.4374. PMID 11178896.
  • Bielli A, Thörnqvist PO, Hendrick AG, Finn R, Fitzgerald K, McCaffrey MW (Mar 2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochemical and Biophysical Research Communications. 281 (5): 1141–53. doi:10.1006/bbrc.2001.4468. PMID 11243854.
  • Yu J, Yu L, Chen Z, Zheng L, Chen X, Wang X, Ren D, Zhao S (Mar 2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Research. Molecular Brain Research. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
  • Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M (Jul 2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes". The Journal of Neuroscience. 22 (13): 5393–402. doi:20026552. PMID 12097491. {{cite journal}}: Check |doi= value (help)
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