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Tumor protein p53 binding protein 1
Protein TP53BP1 PDB 1gzh.png
PDB rendering based on 1gzh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TP53BP1 ; 53BP1; p202; p53BP1
External IDs OMIM605230 MGI1351320 HomoloGene4137 GeneCards: TP53BP1 Gene
RNA expression pattern
PBB GE TP53BP1 203050 at tn.png
More reference expression data
Species Human Mouse
Entrez 7158 27223
Ensembl ENSG00000067369 ENSMUSG00000043909
UniProt Q12888 P70399
RefSeq (mRNA) NM_001141979 NM_001290830
RefSeq (protein) NP_001135451 NP_001277759
Location (UCSC) Chr 15:
43.4 – 43.51 Mb
Chr 2:
121.19 – 121.27 Mb
PubMed search [1] [2]

Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.[1][2][3]

Clinical significance[edit]

53BP1 is underexpressed in most cases of triple-negative breast cancer.[4]


53BP1 has been shown to interact with Histone H4 dimethylated or monomethylated at Lysine 20,[5] Replication protein A1,[6] RPA2,[6] E2F1,[7] Ataxia telangiectasia mutated,[8][9] p53,[1][10][11][12][13][14][15] PAXIP1,[16][17] DYNLL1,[13] H2AFX[8][9][11] and Bloom syndrome protein.[11]


  1. ^ a b Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S (Jul 1994). "Two cellular proteins that bind to wild-type but not mutant p53". Proc Natl Acad Sci U S A 91 (13): 6098–102. doi:10.1073/pnas.91.13.6098. PMC 44145. PMID 8016121. 
  2. ^ Iwabuchi K, Li B, Massa HF, Trask BJ, Date T, Fields S (Nov 1998). "Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2". J Biol Chem 273 (40): 26061–8. doi:10.1074/jbc.273.40.26061. PMID 9748285. 
  3. ^ "Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". 
  4. ^ Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J (June 2010). "53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers". Nat. Struct. Mol. Biol. 17 (6): 688–95. doi:10.1038/nsmb.1831. PMC 2912507. PMID 20453858. 
  5. ^ Botuyan, Maria Victoria; Lee Joseph; Ward Irene M; Kim Ja-Eun; Thompson James R; Chen Junjie; Mer Georges (Dec 2006). "Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair". Cell 127 (7): 1361–73. doi:10.1016/j.cell.2006.10.043. ISSN 0092-8674. PMC 1804291. PMID 17190600. 
  6. ^ a b Yoo, E; Kim Byung U; Lee Seung Youn; Cho Chae Hyun; Chung Jay H; Lee Chang-Hun (Aug 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene (England) 24 (35): 5423–30. doi:10.1038/sj.onc.1208710. ISSN 0950-9232. PMID 15856006. 
  7. ^ Choubey, D; Li S J; Datta B; Gutterman J U; Lengyel P (Oct 1996). "Inhibition of E2F-mediated transcription by p202". EMBO J. (ENGLAND) 15 (20): 5668–78. ISSN 0261-4189. PMC 452311. PMID 8896460. 
  8. ^ a b Fernandez-Capetillo, Oscar; Chen Hua-Tang, Celeste Arkady, Ward Irene, Romanienko Peter J, Morales Julio C, Naka Kazuhito, Xia Zhenfang, Camerini-Otero R Daniel, Motoyama Noboru, Carpenter Phillip B, Bonner William M, Chen Junjie, Nussenzweig André (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nat. Cell Biol. (England) 4 (12): 993–7. doi:10.1038/ncb884. ISSN 1465-7392. PMID 12447390. 
  9. ^ a b Ward, Irene M; Minn Kay; Jorda Katherine G; Chen Junjie (May 2003). "Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX". J. Biol. Chem. (United States) 278 (22): 19579–82. doi:10.1074/jbc.C300117200. ISSN 0021-9258. PMID 12697768. 
  10. ^ Derbyshire, Dean J; Basu Balaku P; Serpell Louise C; Joo Woo S; Date Takayasu; Iwabuchi Kuniyoshi; Doherty Aidan J (Jul 2002). "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor". EMBO J. (England) 21 (14): 3863–72. doi:10.1093/emboj/cdf383. ISSN 0261-4189. PMC 126127. PMID 12110597. 
  11. ^ a b c Sengupta, Sagar; Robles Ana I, Linke Steven P, Sinogeeva Natasha I, Zhang Ran, Pedeux Remy, Ward Irene M, Celeste Arkady, Nussenzweig André, Chen Junjie, Halazonetis Thanos D, Harris Curtis C (Sep 2004). "Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest". J. Cell Biol. (United States) 166 (6): 801–13. doi:10.1083/jcb.200405128. ISSN 0021-9525. PMC 2172115. PMID 15364958. 
  12. ^ Ekblad, Caroline M S; Friedler Assaf; Veprintsev Dmitry; Weinberg Richard L; Itzhaki Laura S (Mar 2004). "Comparison of BRCT domains of BRCA1 and 53BP1: A biophysical analysis". Protein Sci. (United States) 13 (3): 617–25. doi:10.1110/ps.03461404. ISSN 0961-8368. PMC 2286730. PMID 14978302. 
  13. ^ a b Lo, Kevin W-H; Kan Ho-Man; Chan Ling-Nga; Xu Wei-Guang; Wang Ke-Peng; Wu Zhenguo; Sheng Morgan; Zhang Mingjie (Mar 2005). "The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation". J. Biol. Chem. (United States) 280 (9): 8172–9. doi:10.1074/jbc.M411408200. ISSN 0021-9258. PMID 15611139. 
  14. ^ Joo, Woo S; Jeffrey Philip D; Cantor Sharon B; Finnin Michael S; Livingston David M; Pavletich Nikola P (Mar 2002). "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes Dev. (United States) 16 (5): 583–93. doi:10.1101/gad.959202. ISSN 0890-9369. PMC 155350. PMID 11877378. 
  15. ^ Derbyshire, Dean J; Basu Balaku P; Date Takayasu; Iwabuchi Kuniyoshi; Doherty Aidan J (Oct 2002). "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 58 (Pt 10 Pt 2): 1826–9. doi:10.1107/S0907444902010910. ISSN 0907-4449. PMID 12351827. 
  16. ^ Jowsey, Paul A; Doherty Aidan J; Rouse John (Dec 2004). "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation". J. Biol. Chem. (United States) 279 (53): 55562–9. doi:10.1074/jbc.M411021200. ISSN 0021-9258. PMID 15456759. 
  17. ^ Manke, Isaac A; Lowery Drew M; Nguyen Anhco; Yaffe Michael B (Oct 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science (United States) 302 (5645): 636–9. doi:10.1126/science.1088877. PMID 14576432. 

Further reading[edit]