Buccal administration: Difference between revisions
Content deleted Content added
m Task 18 (cosmetic): eval 3 templates: del empty params (5×); |
Tags: Mobile edit Mobile app edit Android app edit |
||
| Line 1: | Line 1: | ||
'''Buccal administration''' is a [[Topical medication|topical]] [[route of administration]] by which [[medication|drug]]s held or applied in the [[buccal space|bucca]]l ({{IPAc-en|ˈ|b|ʌ|k|əl}}) area (in the [[cheek]]) diffuse through the [[oral mucosa]] ([[Tissue (biology)|tissues]] which line the [[Human mouth|mouth]]) and enter directly into the [[systemic circulation|bloodstream]]. Buccal administration may provide better [[bioavailability]] of some drugs and a more rapid [[onset of action]] compared to oral administration because the medication does not pass through the [[Human digestive system|digestive system]] and thereby avoids [[first pass metabolism]].<ref name=Sattar>{{cite journal | last1 = Sattar | first1 = M | last2 = Sayed | first2 = OM | last3 = Lane | first3 = ME | date = Aug 2014 | title = Oral transmucosal drug delivery--current status and future prospects | journal = Int J Pharm | volume = 471 | issue = 1-2| pages = 498–506 | doi = 10.1016/j.ijpharm.2014.05.043 | pmid = 24879936 }}</ref> |
'''Buccal administration''' is a [[Topical medication|topical]] [[route of administration]] by which [[medication|drug]]s held or applied in the [[buccal space|bucca]]l ({{IPAc-en|ˈ|b|ʌ|k|əl}}) area (in the [[cheek]]) diffuse through the [[oral mucosa]] ([[Tissue (biology)|tissues]] which line the [[Human mouth|mouth]]) and enter directly into the [[systemic circulation|bloodstream]]. Buccal administration may provide better [[bioavailability]] of some drugs and a more rapid [[onset of action]] compared to oral administration because the medication does not pass through the [[Human digestive system|digestive system]] and thereby avoids [[first pass metabolism]].<ref name=Sattar>{{cite journal | last1 = Sattar | first1 = M | last2 = Sayed | first2 = OM | last3 = Lane | first3 = ME | date = Aug 2014 | title = Oral transmucosal drug delivery--current status and future prospects | journal = Int J Pharm | volume = 471 | issue = 1-2| pages = 498–506 | doi = 10.1016/j.ijpharm.2014.05.043 | pmid = 24879936 }}</ref> |
||
As of May 2014, the psychiatric drug [[asenapine]]; the opioid drugs [[buprenorphine]], [[naloxone]], and [[fentanyl]]; the cardiovascular drug [[nitroglycerin]]; the nausea medication [[ |
As of May 2014, the psychiatric drug [[asenapine]]; the opioid drugs [[buprenorphine]], [[naloxone]], and [[fentanyl]]; the cardiovascular drug [[nitroglycerin]]; the nausea medication [[prochlorperazine]]; the hormone replacement therapy [[testosterone (medication)|testosterone]]; and [[nicotine]] as a smoking cessation aid were commercially available in buccal forms,<ref name=Sattar/> as was [[midazolam]], an [[anticonvulsant]], used to treat acute [[epileptic seizures]].<ref>{{cite journal | last1 = Brigo | first1 = F | display-authors = etal | year = 2015 | title = Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis | journal = Epilepsy Behav | volume = 49 | page = 325–36 | doi = 10.1016/j.yebeh.2015.02.030 | pmid = 25817929 }}</ref> |
||
Buccal administration of [[vaccines]] has been studied, but there are challenges to this approach due to [[immune tolerance]] mechanisms that prevent the body from over-reacting to [[immunogen]]s encountered in the course of daily life.<ref>{{cite journal | last1 = Kraan | first1 = H | display-authors = etal | date = Sep 2014 | title = Buccal and sublingual vaccine delivery | journal = J Control Release | volume = 190 | pages = 580–92 | doi = 10.1016/j.jconrel.2014.05.060 | pmid = 24911355 | doi-access = free }}</ref> |
Buccal administration of [[vaccines]] has been studied, but there are challenges to this approach due to [[immune tolerance]] mechanisms that prevent the body from over-reacting to [[immunogen]]s encountered in the course of daily life.<ref>{{cite journal | last1 = Kraan | first1 = H | display-authors = etal | date = Sep 2014 | title = Buccal and sublingual vaccine delivery | journal = J Control Release | volume = 190 | pages = 580–92 | doi = 10.1016/j.jconrel.2014.05.060 | pmid = 24911355 | doi-access = free }}</ref> |
||
Revision as of 16:40, 11 August 2021
Buccal administration is a topical route of administration by which drugs held or applied in the buccal (/ˈbʌkəl/) area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream. Buccal administration may provide better bioavailability of some drugs and a more rapid onset of action compared to oral administration because the medication does not pass through the digestive system and thereby avoids first pass metabolism.[1]
As of May 2014, the psychiatric drug asenapine; the opioid drugs buprenorphine, naloxone, and fentanyl; the cardiovascular drug nitroglycerin; the nausea medication prochlorperazine; the hormone replacement therapy testosterone; and nicotine as a smoking cessation aid were commercially available in buccal forms,[1] as was midazolam, an anticonvulsant, used to treat acute epileptic seizures.[2]
Buccal administration of vaccines has been studied, but there are challenges to this approach due to immune tolerance mechanisms that prevent the body from over-reacting to immunogens encountered in the course of daily life.[3]
See also
References
- ^ a b Sattar, M; Sayed, OM; Lane, ME (Aug 2014). "Oral transmucosal drug delivery--current status and future prospects". Int J Pharm. 471 (1–2): 498–506. doi:10.1016/j.ijpharm.2014.05.043. PMID 24879936.
- ^ Brigo, F; et al. (2015). "Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis". Epilepsy Behav. 49: 325–36. doi:10.1016/j.yebeh.2015.02.030. PMID 25817929.
- ^ Kraan, H; et al. (Sep 2014). "Buccal and sublingual vaccine delivery". J Control Release. 190: 580–92. doi:10.1016/j.jconrel.2014.05.060. PMID 24911355.
-solution.jpg)
