Talk:Azathioprine

What do we mean by Safe?

Stating a drug as being safe is an overly generalised and inappropriate comment. Indeed this drug may be associated with increased cancer risk and has been known to cause Hepatic VOD. It carries with it some risks vis-à-vis reproduction. I doubt if the normal reader would consider "safe" the appropriate word, certainly as a clinical scientist I do not. It would be more appropriate to view these issues in terms of cost to benefit analysis.

Given the use of this wording I doubt the objectiveness of the perspective of this article, thus I removed the word safe to allow the reader, given the side-effects listed and those mentioned here, to draw their own conclusions. SMSIRL 02:23, 12 May 2006 (UTC)

Mergefrom suggestion (Imuran)

My understanding is that in most cases stand-alone articles for brands of drugs for which there is a generic article aren't encouraged. My reading of the content of Imuran suggests there isn't much specifically about the brand vs. the substance in that stub-article. I'll leave it to a second- or third-opinion to actually enact or approve the merger. Regards, --User:Ceyockey (talk to me) 16:08, 3 December 2006 (UTC)

Side effects

"Side effects are uncommon, but include nausea, HA and rash."

What is HA? Harksaw 18:31, 1 October 2007 (UTC)

--- i was wondering the same thing - headache???? Woood 14:31, 2 October 2007 (UTC)

I'm guessing "HA" might mean uncontrollable laughter?

IBD

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2036.2008.03732.x large series in IBD. JFW | T@lk 13:41, 15 May 2008 (UTC)

Drug Interactions

Azathioprine appears to be a potent antagonist of warfarin and may be hazardous to patients with an underlying hypercoaguable state. --lbeben 01:48, 23 November 2008 (UTC) —Preceding unsigned comment added by Lbeben (talk • contribs)

Error in image

The image in the Azathioprine article says HC3 when it should say H3C. I don't know how to edit the image so could someone who know how to do that correct it? Thanks. HowardRubin (talk) 03:43, 7 September 2009 (UTC)

Use in cases of eczema / atopic dermatitis

This information might be added to this article.

In the spring of 2006 researchers reported on a study funded by the British Skin Foundation (Dr. Simon Meggitt, Royal Victoria infirmary & Prof. Nick Reynolds, Newcastle University) that azathioprine holds great promise for the treatment of moderate to severe eczema and atopic dermatitis. As a result of this study and other anecdotal evidence in the 40 year history of azathioprine use, the (British) National Eczema Society now lists azathioprine as a third-line treatment for severe to moderate cases of these skin diseases.

S. Meggitt, J. Gray, N. Reynolds Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial The Lancet, Volume 367, Issue 9513, Pages 839-846, 2006.

S. Brown, N.J. Reynolds Atopic and non-atopic eczema British Medical Journal, Issue 332, Pages 584-588, 2006.

--Symmerhill (a.k.a. Summerhill) (talk) 19:52, 27 October 2009 (UTC)

Pronunciation

How do you pronounce "Azathioprine"? is it AY-zuh-THIGH-oh-preen or uh-ZATH-ee-oh-preen or something else? nohat (talk) 21:47, 21 May 2010 (UTC)

I've added the pronunciation as per John C. Wells's Long Pronunciation Dictionary: AZ-uh-THIGH-oh-preen. +Angr 16:25, 23 May 2010 (UTC)