Talk:Fexofenadine

Expansion

This article needs to be expanded Jdoelder (talk) 20:19, 21 May 2009 (UTC)

In terms of mechanism of action. Jdoelder (talk) 18:43, 30 May 2009 (UTC)

OTC in U.S.A.?

Is there any indication that this will go over-the-counter in the U.S.A like Claritin and Zyrtec? I hope it will be OTC sooon as it seems to be the best and safest of the three. —Preceding unsigned comment added by 4.224.3.34 (talk) 01:15, 6 July 2008 (UTC)

Yes. The FDA approved Allegra for OTC sale at the end of Jan 2011, with sales expected to start in March 2011 in the USA.

Reference: [[1]] —Preceding unsigned comment added by 76.103.51.142 (talk) 01:01, 4 February 2011 (UTC)

question

does anyone know which enantiomer of the molecule works the best? Or is it exactly equal? Sikkema (talk) 14:27, 4 June 2008 (UTC)

Does anyone know if the body develops a tolerance for this? I seem to respond less well to doses (to combat serious hay fever) of 300 mg/day than I used to.... any response welcome... 77.251.51.253 (talk) 19:52, 1 June 2008 (UTC)

when I typed in "fexofenadine" to the search it gave no results

works for me. Maybe you mistyped it and didn't notice? Graham 11:42, 6 April 2006 (UTC)

In the opening section, the article mentions "potentially fatal contraindications". But there is no citation for this statement, and there is no other mention of it in the article. Even in the "overdose" section, it does not seem to support this statement. How often is this an issue? How many people have died in this way? I think the statement that I quoted above should be removed, unless it can be supported with some facts. Deepfryer99 21:26, 26 August 2007 (UTC)

The statement clearly concerns terfenadine, an older drug which was replaced by fexofenadine. Further details and links can be found in the terfenadine article. — Jan (158.195.162.8 (talk) 20:33, 29 May 2008 (UTC))

The History section mentions AMRI with no explanation or link. — Jan (158.195.162.8 (talk) 20:24, 29 May 2008 (UTC)

Wh

OK to remove specific dosing instructions?

Per this email thread? Thanks, GChriss <always listening><c> 05:22, 8 February 2008 (UTC)

Dosing Instructions?

According to the offical allegra website, their dosing instructions state:

It is recommended that the administration of ALLEGRA-D 12 HOUR with food should be avoided.

Link: http://products.sanofi-aventis.us/allegra_D12/allegra_d12.html#dosage

I would appreciate it if anyone could weigh in on this. Thanks! monkeynoze (talk) 22:33, 26 May 2008 (UTC)

The intake of food could possibly diminish the effects of the drug, simply because eating adds a lot of material to the intestines, so that the adsorption into the body is not that quick. No harmful interactions are expected. Sikkema (talk) 14:30, 4 June 2008 (UTC)

Synthesis

SVG file contained has the organolithium compound incorrectly drawn with a cyanide group. I've quickly switched it over with the GIF version which is correct, but someone with more time on their hands might want to rework the SVG file. —Preceding unsigned comment added by 86.136.142.224 (talk) 14:14, 16 May 2010 (UTC)

can tb. fexofenadine used during pregnancy?

can tb. fexofenadine used during pregnancy? — Preceding unsigned comment added by 118.102.186.1 (talk) 07:26, 16 July 2011 (UTC)

Inconsistency Between Intro & Side Effects & Mechanism Of Actions Sections

The following 3 copy and pastes from the article seem to provide conflicting conclusions, about the way the drug works and also whether it can or cannot cause drowsiness. The intro section says it does not readily cross the blood-brain barrier, so it causes less drowsiness. The Side Effects section says that drowsiness and sleepiness are two of the most common side effects. And the Mechanism of Action section says that it cannot cross the blood-brain barrier and therefore does not cause drowsiness.

If the last statement is accurate, that would seem to make an awfully strong selling point for using this drug for allergy relief. But the other two sections cast doubt on whether that is true or not. I don't know if this is just a difference of opinion from different article sources, or whether the science is inconclusive. But this would seem to be a great thing to get clarification/corrections on, for people like me who don't know what to believe after reading this.

Here are the 3 copy and pastes from the article sections:

(from introduction) Fexofenadine, like other second- and third-generation antihistamines, does not readily cross the blood–brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.

Side effects The most common side effects are headache, nausea, dizziness, drowsiness and sleepiness;

Mechanism of action Fexofenadine cannot cross the blood–brain barrier and therefore does not cause drowsiness.

Vol-Addict