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==Use in traditional Eastern medicine==
==Use in traditional Eastern medicine==
The sclerotia from which hen of the woods arises have been used in traditional [[Traditional Chinese Medicine|Chinese]] and [[Japan]]ese medicine to enhance the [[immune system]]. Researchers have also indicated that whole maitake has the ability to regulate [[blood pressure]], [[glucose]], [[insulin]], and both [[blood plasma|serum]] and [[liver]] [[lipid]]s, such as [[cholesterol]], [[triglyceride]]s, and [[phospholipid]]s, and may also be useful for weight loss.
The sclerotia from which hen of the woods arises have been used in traditional [[Traditional Chinese Medicine|Chinese]] and [[Japan]]ese medicine to enhance the [[immune system]]. Researchers have also indicated that whole maitake has the ability to regulate [[blood pressure]], [[glucose]], [[insulin]], and both [[blood plasma|serum]] and [[liver]] [[lipid]]s, such as [[cholesterol]], [[triglyceride]]s, and [[phospholipid]]s, and may also be useful for weight loss.{{Citation needed}}


Maitake is rich in [[mineral]]s (such as [[potassium]], [[calcium]], and [[magnesium]]), various [[vitamin]]s ([[Vitamin B2|B<sub>2</sub>]], [[Vitamin D2|D<sub>2</sub>]] and [[niacin]]), [[fiber]]s and [[amino acid]]s. One active constituent in Maitake for enhancing the immune activity was identified in the late 1980s as a protein-bound [[beta-glucan]] compound.
Maitake is rich in [[mineral]]s (such as [[potassium]], [[calcium]], and [[magnesium]]), various [[vitamin]]s ([[Vitamin B2|B<sub>2</sub>]], [[Vitamin D2|D<sub>2</sub>]] and [[niacin]]), [[fiber]]s and [[amino acid]]s. One active constituent in Maitake for enhancing the immune activity was identified in the late 1980s as a protein-bound [[beta-glucan]] compound.

Revision as of 18:08, 2 December 2012

Maitake
Scientific classification
Kingdom:
Fungi
Phylum:
Basidiomycota
Class:
Agaricomycetes
Order:
Polyporales
Family:
Meripilaceae
Genus:
Grifola
Species:
G. frondosa
Binomial name
Grifola frondosa
(Dicks.) Gray
Synonyms

Polyporus frondosus Fr.[1]

Grifola frondosa is a polypore mushroom that grows in clusters at the base of trees, particularly oaks. The mushroom is commonly known among English speakers as hen-of-the-woods, ram's head and sheep's head. In the United States' supplement market, as well as in Asian grocery stores, the mushroom is known by its Japanese name maitake (舞茸), which means "dancing mushroom". Throughout Italian American communities in the northeastern United States, it is commonly known as the signorina mushroom. G. frondosa should not be confused with Laetiporus sulphureus, another edible bracket fungus that is commonly called chicken of the woods or "sulphur shelf". The fungus becomes inedible like all polypores when they are older, because it is too tough to eat.

The fungus is native to the northeastern part of Japan and North America, and is prized in traditional Chinese and Japanese herbology as a medicinal mushroom, an aid to balance out altered body systems to a normal level. Due to the taste and texture of the mushroom, it is widely eaten in Japan, although the mushroom has been alleged to cause allergic reactions in rare cases.

Grifola frondosa
View the Mycomorphbox template that generates the following list
Pores on hymenium
Cap is offset or indistinct
Hymenium is decurrent
Lacks a stipe
Spore print is white
Ecology is parasitic
Edibility is choice

Description

Like the sulphur shelf mushroom, G. frondosa is a perennial fungus that often grows in the same place for a number of years in succession. It occurs most prolifically in the northeastern regions of the United States, but has been found as far west as Idaho.

G. frondosa grows from an underground tuber-like structure known as a sclerotium, about the size of a potato. The fruiting body, occurring as large as 100 cm, is a cluster consisting of multiple grayish-brown caps which are often curled or spoon-shaped, with wavy margins and 2–7 cm broad. The undersurface of each cap bears approximately one to three pores per millimeter, with the tubes rarely deeper than 3 mm. The milky-white stipe (stalk) has a branchy structure and becomes tough as the mushroom matures.

In Japan, the Maitake can grow to more than 50 pounds (20 kilograms), earning this giant mushroom the title "King of Mushrooms". Maitake is one of the major culinary mushrooms used in Japan, the others being shiitake, shimeji and enoki. They are used in a wide variety of dishes, often being a key ingredient in nabemono or cooked in foil with butter.

Use in traditional Eastern medicine

The sclerotia from which hen of the woods arises have been used in traditional Chinese and Japanese medicine to enhance the immune system. Researchers have also indicated that whole maitake has the ability to regulate blood pressure, glucose, insulin, and both serum and liver lipids, such as cholesterol, triglycerides, and phospholipids, and may also be useful for weight loss.[citation needed]

Maitake is rich in minerals (such as potassium, calcium, and magnesium), various vitamins (B2, D2 and niacin), fibers and amino acids. One active constituent in Maitake for enhancing the immune activity was identified in the late 1980s as a protein-bound beta-glucan compound.

Maitake research

In 2009, a phase I/II human trial, conducted by Memorial Sloan–Kettering Cancer Center, showed Maitake could stimulate the immune systems of breast cancer patients.[2] Small experiments with human cancer patients, have shown Maitake can stimulate immune system cells, like NK cells.[3][4] In vitro research has also shown Maitake can stimulate immune system cells.[5] An in vivo experiment showed that Maitake could stimulate both the innate immune system and adaptive immune system.[6]

In vitro research has shown Maitake can induce apoptosis in cancer cell lines (human prostatic cancer cells, Hep 3B cells, SGC-7901 cells, murine skin carcinoma cells)[7][8][9][10] as well as inhibit the growth of various types of cancer cells (canine cancer cells, bladder cancer cells).[11][12][13] Small studies with human cancer patients, revealed a portion of the Maitake mushroom, known as the "Maitake D-fraction", possess anti-cancer activity.[14][15] In vitro research demonstrated the mushroom has potential anti-metastatic properties.[16] In 1997, the U.S. Food and Drug Administration (FDA) approved an Investigational New Drug Application for a portion of the mushroom.[17]

Research has shown Maitake has a hypoglycemic effect, and may be beneficial for the management of diabetes.[18][19][20][21][22][23] The reason Maitake lowers blood sugar is due to the fact the mushroom naturally contains an alpha glucosidase inhibitor.[24]

Maitake contains antioxidants and may partially inhibit the enzyme cyclooxygenase.[25] An experiment showed that an extract of Maitake inhibited angiogenesis via inhibition of the vascular endothelial growth factor (VEGF).[26]

Lys-N is a unique protease found in Maitake.[27] Lys-N is used for proteomics experiments due to its protein cleavage specificity.[28]

  • Maitake mushroom
    Maitake mushroom
  • Wild Hen of the Woods on an old oak tree.
    Wild Hen of the Woods on an old oak tree.
  • Wild Hen of the Woods.
    Wild Hen of the Woods.
  • Wild Hen of the Woods on an oak tree.
    Wild Hen of the Woods on an oak tree.
  • Close shot of Hen-of-the-woods
    Close shot of Hen-of-the-woods
  • Grifola frondosa cross-section measuring apx. 30x20cm.
    Grifola frondosa cross-section measuring apx. 30x20cm.
  • Several nice clusters
    Several nice clusters

See also

References

  1. ^ McIlvaine, Charles; Robert K. Macadam; and Robert L. Shaffer. 1973. One Thousand American Fungi. Dover Publications. New York. 729 pp. (Polyporus frondosus, pp. 482-483 & Plate CXXVIII.)
  2. ^ Deng G, Lin H, Seidman A; et al. (2009). "A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects". Journal of Cancer Research and Clinical Oncology. 135 (9): 1215–21. doi:10.1007/s00432-009-0562-z. PMID 19253021. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Kodama N, Komuta K, Nanba H (2003). "Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients". Journal of Medicinal Food. 6 (4): 371–7. doi:10.1089/109662003772519949. PMID 14977447.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Kodama N, Komuta K, Sakai N, Nanba H (2002). "Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells". Biological & Pharmaceutical Bulletin. 25 (12): 1647–50. doi:10.1248/bpb.25.1647. PMID 12499658. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H (2005). "Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa". Oncology Reports. 13 (3): 497–502. PMID 15706424. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. ^ Kodama N, Murata Y, Nanba H (2004). "Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice". Journal of Medicinal Food. 7 (2): 141–5. doi:10.1089/1096620041224012. PMID 15298759.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Fullerton SA, Samadi AA, Tortorelis DG; et al. (2000). "Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide)". Molecular Urology. 4 (1): 7–13. PMID 10851301. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  8. ^ Lin JT, Liu WH (2006). "o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis". Journal of Agricultural and Food Chemistry. 54 (20): 7564–9. doi:10.1021/jf0616762. PMID 17002422. {{cite journal}}: Unknown parameter |month= ignored (help)
  9. ^ Cui FJ, Li Y, Xu YY; et al. (2007). "Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801". Toxicology in Vitro. 21 (3): 417–27. doi:10.1016/j.tiv.2006.10.004. PMID 17150327. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  10. ^ Gu YH, Belury MA (2005). "Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes". Cancer Letters. 220 (1): 21–8. doi:10.1016/j.canlet.2004.06.037. PMID 15737684. {{cite journal}}: Unknown parameter |month= ignored (help)
  11. ^ Konno S (2004). "Potential growth inhibitory effect of maitake D-fraction on canine cancer cells". Veterinary Therapeutics. 5 (4): 263–71. PMID 15719326.
  12. ^ Konno S (2007). "Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts" (PDF). Alternative Medicine Review. 12 (1): 63–8. PMID 17397268. {{cite journal}}: Unknown parameter |month= ignored (help)
  13. ^ Nanba H (1995). "Activity of maitake D-fraction to inhibit carcinogenesis and metastasis". Annals of the New York Academy of Sciences. 768 (1): 243–5. doi:10.1111/j.1749-6632.1995.tb12130.x. PMID 8526356. {{cite journal}}: Unknown parameter |month= ignored (help)
  14. ^ Kodama N, Komuta K, Nanba H (2002). "Can maitake MD-fraction aid cancer patients?" (PDF). Alternative Medicine Review. 7 (3): 236–9. PMID 12126464. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  15. ^ Nanba H, Kubo K (1997). "Effect of Maitake D-fraction on cancer prevention". Annals of the New York Academy of Sciences. 833 (1 Cancer): 204–7. doi:10.1111/j.1749-6632.1997.tb48611.x. PMID 9616756. {{cite journal}}: Unknown parameter |month= ignored (help)
  16. ^ Masuda Y, Murata Y, Hayashi M, Nanba H (2008). "Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells". Biological & Pharmaceutical Bulletin. 31 (6): 1104–8. doi:10.1248/bpb.31.1104. PMID 18520039. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  17. ^ http://sci.cancerresearchuk.org/labs/med_mush/final_pdfs/chapt7.pdf[dead link]
  18. ^ Konno S, Tortorelis DG, Fullerton SA, Samadi AA, Hettiarachchi J, Tazaki H (2001). "A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients". Diabetic Medicine. 18 (12): 1010. doi:10.1046/j.1464-5491.2001.00532-5.x. PMID 11903406. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  19. ^ Hong L, Xun M, Wutong W (2007). "Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice". The Journal of Pharmacy and Pharmacology. 59 (4): 575–82. doi:10.1211/jpp.59.4.0013. PMID 17430642. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  20. ^ Kubo K, Aoki H, Nanba H (1994). "Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I". Biological & Pharmaceutical Bulletin. 17 (8): 1106–10. doi:10.1248/bpb.17.1106. PMID 7820117. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  21. ^ Lo HC, Hsu TH, Chen CY (2008). "Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats". The American Journal of Chinese Medicine. 36 (2): 265–85. doi:10.1142/S0192415X0800576X. PMID 18457360.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  22. ^ Manohar V, Talpur NA, Echard BW, Lieberman S, Preuss HG (2002). "Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice". Diabetes, Obesity & Metabolism. 4 (1): 43–8. doi:10.1046/j.1463-1326.2002.00180.x. PMID 11874441. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  23. ^ Horio H, Ohtsuru M (2001). "Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats". Journal of Nutritional Science and Vitaminology. 47 (1): 57–63. doi:10.3177/jnsv.47.57. PMID 11349892. {{cite journal}}: Unknown parameter |month= ignored (help)
  24. ^ Matsuur H, Asakawa C, Kurimoto M, Mizutani J (2002). "Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa". Bioscience, Biotechnology, and Biochemistry. 66 (7): 1576–8. doi:10.1271/bbb.66.1576. PMID 12224646. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  25. ^ Zhang Y, Mills GL, Nair MG (2002). "Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa". Journal of Agricultural and Food Chemistry. 50 (26): 7581–5. doi:10.1021/jf0257648. PMID 12475274. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  26. ^ Lee JS, Park BC, Ko YJ; et al. (2008). "Grifola frondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation". Journal of Medicinal Food. 11 (4): 643–51. doi:10.1089/jmf.2007.0629. PMID 19053855. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  27. ^ Nonaka, T (1998-07). "Kinetic characterization of lysine-specific metalloendopeptidases from Grifola frondosa and Pleurotus ostreatus fruiting bodies". Journal of Biochemistry. 124 (1): 157–162. ISSN 0021-924X. PMID 9644258. Retrieved 2010-07-01. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  28. ^ Taouatas, Nadia (2008-05). "Straightforward ladder sequencing of peptides using a Lys-N metalloendopeptidase". Nat Meth. 5 (5): 405–407. doi:10.1038/nmeth.1204. ISSN 1548-7091. PMID 18425140. {{cite journal}}: |access-date= requires |url= (help); Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
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