PPIH: Difference between revisions

PPIH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MZW, 1QOI
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	OMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,676,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,177,743 bp
RNA expression pattern
	Top expressed in
	embryo; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; granulocyte; ; secondary oocyte; ; rectum; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; lymph node;
	Top expressed in
	ventricular zone; ; embryo; ; spermatocyte; ; embryo; ; yolk sac; ; morula; ; blastocyst; ; spermatid; ; genital tubercle; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonucleoprotein complex binding; isomerase activity; protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding; unfolded protein binding;
Cellular component	cytoplasm; nuclear speck; U4/U6 x U5 tri-snRNP complex; spliceosomal complex; nucleus; nucleoplasm; U4/U6 snRNP;
Biological process	mRNA splicing, via spliceosome; mRNA processing; positive regulation of viral genome replication; protein folding; RNA splicing; protein-containing complex assembly; protein peptidyl-prolyl isomerization; angiogenesis; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10465
	66101
	ENSG00000171960
	ENSMUSG00000060288
	O43447
	Q9D868
	NM_006347; NM_001330510
	NM_001110129; NM_001110130; NM_028677
	NP_001317439; NP_006338
	NP_001103599; NP_001103600; NP_082953
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 01:25, 4 January 2019

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
^ Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
^ "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

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 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Reidt U |title=Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7439–42 |year= 2000 |pmid= 10713041 |doi=10.1074/jbc.275.11.7439  |name-list-format=vanc| author2=Reuter K  | author3=Achsel T  | display-authors=3  | last4=Ingelfinger  | first4=D  | last5=Lührmann  | first5=R  | last6=Ficner  | first6=R  }}
+*{{cite journal  | author=Reidt U |title=Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7439–42 |year= 2000 |pmid= 10713041 |doi=10.1074/jbc.275.11.7439  |name-list-format=vanc| author2=Reuter K  | author3=Achsel T  | display-authors=3  | last4=Ingelfinger  | first4=D  | last5=Lührmann  | first5=R  | last6=Ficner  | first6=R  |url=http://pubman.mpdl.mpg.de/pubman/item/escidoc:600339/component/escidoc:2224255/600339.pdf}}
 *{{cite journal  |vauthors=Horowitz DS, Lee EJ, Mabon SA, Misteli T |title=A cyclophilin functions in pre-mRNA splicing |journal=EMBO J. |volume=21 |issue= 3 |pages= 470–80 |year= 2002 |pmid= 11823439 |doi=10.1093/emboj/21.3.470  | pmc=125845  }}
 *{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}

Revision as of 01:25, 4 January 2019

References

Further reading