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Revision as of 03:49, 27 January 2024 by Maxim Masiutin(talk | contribs)(Removed 18 name-list-style and display-authors attributes from cite entries that match that of "cs1 config" to exclude the article from Category:CS1 maint: overridden setting. Put the {{Short description}} template first as prescribed by MOS:ORDER.)
Importin-7 is a protein that in humans is encoded by the IPO7gene.[5][6]
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.[6]
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