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Clonaid

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File:RMX2010 Clonaid.jpg
The device at the bottom of this picture is the RMX2010 embryonic cell fusion machine developed by Clonaid.[1] The device on the top part of the picture (not made by Clonaid) is a low-end Tektronix oscilloscope commonly used in electrical engineering labs.
Part of a series of articles on the
Raëlian movement
Doctrines

Clonaid is the project name for a self-described "human cloning company" founded in 1997 and associated with the Raëlian Movement, which sees cloning as part of the path to immortality. In December 27, 2002, Clonaid's Chief Executive Officer Brigitte Boisselier claimed that a baby clone, named Eve, was born. Clonaid has claimed that 13 cloned babies had resulted out of 30 attempts at pregnancy.

Media subsequently covered the lead claim and fostered serious criticism and ethical debate that lasted more than a year. Florida attorney Bernard Siegel tried to appoint a different guardian for Eve and threatened to sue Clonaid. A terminology dispute over whether Clonaid is really a company or just a project name led to accusations that that the whole Clonaid project was a sham.

Some experts saw the cloning claim as plausible due to greater understanding of reproduction in humans versus animals as well as Clonaid's greater access to surrogates and donors willing to clone. However, scientists in the field condemned Clonaid for premature human experimentation and noted the high incidence of malformations and fetal deaths in animal cloning. Clonaid's defense was that animal In vitro fertilisation (IVF) faced similar problems in the past which are now resolved.

Plans to clone a human being

In May 31, 1997, New Scientist said the International Raëlian Movement had plans of setting up a company to fund the research and development of human cloning. This alarmed bioethicists who were opposed to such plans. They warned lawmakers against failing to regulate human cloning. At the time, European countries such as Britain had banned human cloning, but the United States had merely a moratorium on the use of federal funds for human cloning research. Former United States president Bill Clinton requested that private companies pass their own moratorium. Claude Vorilhon, the founder of Raëlism, was opposed to this move and denied that the technology used to clone was inherently dangerous.[2]

Clonaid revealed their purpose in more detail in June 9, 1997. In it was the intention to offer gay and infertile couples the chance to have genetically identical child and to become a step closer towards the goal of achieving eternal life. According to an internet announcement, the Raëlian leader and a group of investors founded a company in the Bahamas and called it Valiant Venture Ltd., whose mission was a project named Clonaid. Valiant Venture expected to have 1 million potential customers.[3]

In June 15, 1998, Brigitte Boisselier said the headquarters of Clonaid was located in Las Vegas, Nevada and had considerable private funding, but it was not enough to sustain the research that would allow them to clone humans. Although the project's ultimate objective was human cloning, she said that pet cloning would help finance the operations.[4] In December 19, a New Scientist article reported the cost of Clonaid services as being $200,000 US, lower than the $2.3 million dollars that researchers at Texas A&M University planned to use for cloning a dog named Missy. Mainstreams scientists said it was unlikely that Clonaid would be able to clone anything in the near future.[5]

Claude Vorilhon held a meeting in a Montreal hotel on September 21, 2000, where he announced that a wealthy American couple was willing to fund the Clonaid project. The first pending clone, according to Vorilhon at the time, was an American couple's 10-month old girl, who died due to a medical mistake. He said that the couple was willing to pay $500,000 to clone their deceased daughter, but the wife was not willing to be to surrogate mother. Jamie Grifo, a fertility specialist at the New York University School of Medicine and Nobel laureate Paul Berg of Stanford University said that Vorilhon was providing a false hope that the child was going to be the same one. Boisselier revealed the roles of four scientists she says were involved—"a biochemist, a geneticist, a cell fusion expert, and a French medical doctor"—but without revealing their identity. She did not identify of the wealthy American couple.[6]

According to cloning specialist and physiologist George Seidel of Colorado State University, cloning a human being would not be difficult if many people donated their eggs or offered their wombs for implantation of clone embryos. Lee Silver, a molecular biologist from Princeton, noted the advantages that Raëlians had, as a pro-cloning religious group, in finding willing surrogates. A biotechnology company called Advanced Cell Technology had cloned human embryo cells for medical purposes, and its CEO Michael West said that the directions for cloning a human being were available published scientific literature. Some experts noted that scientists reproductive chemistry is understood better in humans than in most animals. For this reason, they think that a higher rate of success is possible in human cloning compared animal cloning. Brigitte Boisselier anticipated that the work could begin on the preserved cells as soon as October, but there was no evidence that Clonaid had medical knowledge necessary for its success. There was no evidence that the Clonaid claim was a more than a publicity stunt.[6]

In March 2001, Boisselier said that a woman would be pregnant with a cloned fetus in April. She said that cells had reached the blastocyst stage, but she refused to speak of any specific implantation or pregnancy associated with them. According to a CNN article that November, the Clonaid laboratory was outside the United States. Clonaid claimed that it had developed human cloned embryos before Advanced Cell Technology was able to do the same.[7] CNN could not confirm the unpublished work. Due to Clonaid's association with Raëlians and the lack of evidence for cloning, authorities remained skeptical as to whether Clonaid could clone anything at all.[8]

Alleged clone baby Eve

In December 27, 2002, Dr. Brigitte Boisselier, a Raëlian bishop and CEO of Clonaid, announced at press conference in Hollywood, Florida that Clonaid had successfully performed the first human reproductive cloning. Boisselier said that the mother delivered Eve by Caesarean section somewhere outside the United States and that both are healthy. Dr. Boisselier did not present the mother or child, or DNA samples that would allow for confirmation of her claim at the press conference. It has subsequently become apparent that she announced the birth prior to genetic testing to evaluate whether the child in question is actually a clone: Dr. Boisselier was therefore stating her belief that her procedure had resulted in a clone, not announcing results showing that the child was a clone.[9] The next day, CNN reports Boisselier as saying that four more clones are one the way.[10]

Two days later, Florida attorney Bernard Siegel filed a petition in the Broward County Circuit Court to have a temporary guardian appointed for the alleged cloned child. As the court case played out over the next month, Dr. Boisselier testified under oath that there was a cloned child, born in Israel. However, Clonaid did not present demonstrative evidence that the child really existed.[11] Bosselier said that Eve would travel to the United States that day for DNA tests. She said that a pediatrician saw Eve and her mother in good condition, but she refused to mention the location of the birth, the testing lab, or the mother's home, which she wanted to reveal at a later time. The mother was said to be 31 years old with an infertile husband.[12]

Michael Guillen, a former ABC science editor, made an agreement with Boisselier for him to choose independent experts to test for a DNA match. Clonaid refused to identify the independent experts, because if revealed too soon, others could track the baby from the testing place into the mother's house. Clonaid said the parents had the final say on whether they want to test the baby and that and that a Dutch lesbian couple would be the parents of the next cloned baby.[13] Bosselier said she would hand over evidence to show that a clone had in fact been born but was concerned that the details of Clonaid's cloning procedure might leak out.[12] The next day, Vorilhon claimed that the baby was healthy. He said those who are against cloning for ethical reasons would be dismayed if the clone baby was in good condition.[12]

Bosselier announced on the following New Year's Day that 20 more implantations of human clones were on the way after the first 10 which happened in the previous year. She said that other companies have used cloning procedures with different specifics that lead to their high failure rate. Clonaid said that if Eve was deformed, someone would abort her. Boisselier argued that procedures involving In vitro fertilisation, miscarriages were more likely than abortions and believed that the same was true for cloning. The human cloning claims were condemned by ethicists doubted by scientists.[12]

University of Wisconsin bioethicist Alta Charo said that even in other ape-like mammals, the risk for miscarriage, birth defects, and life problems remains high. Robert Lanza of Advanced Cell Technologies said that Clonaid has no record of accomplishment for cloning anything, but he said that if Clonaid actually succeeded, there would be public unrest that may lead to the banning of therapeutic cloning, which has the capacity to cure millions of patients. The Vatican said that the claims expressed a mentality that was brutal and lacked ethical consideration. The White House was also critical of the claims.[12]

Three days later, Boisselier claimed that another cloned baby was born to a Dutch lesbian couple in the Netherlands the previous day and stated that there would be four other cloned babies delivered by February 2003. She said that birth mother gave birth to her own clone. An official from the Dutch Health Ministry told Reuters that the Netherlands forbade human cloning but not the birth of baby clones.[14]

Tests cancelled

Micheal Guillen was disappointed when he discovered when Clonaid withdrew their offer to provide the tests. The company said that before the tests were done, the parents wanted to be sure that their baby would not be sent away, but an Florida attorney asked that a guardian for Eve be appointed and threatened the company with a lawsuit. Guillen, who is still skeptical, said it would be unwise to dismiss the Clonaid project without proper confirmation.[15]

Many scientists expected any human clone to encounter health problems. Nevertheless, a spokeswoman for the Japanese Raëlian Movement[16] claimed that a baby boy, cloned from a comatose two year-old of a Japanese couple, was born the previous day. Boisselier said that a surrogate participated since the biological mother was 41 and more likely to have a miscarriage. Scientists know that many cloned animals suffer arthritis and ailments with the lungs and liver, and they are concerned that too many unanswered questions surround the prospect of safe cloning of humans. Clonaid set up press conferences in which they described their method of cloning, but they did not give any details. However, they did say that the third cloning was different, in that did not involve a mothers egg, but the surrogate's egg with the injection of the boy's DNA.[17]

Clonaid representative Thomas Kaenzig refused to testify in a court hearing, but Florida judge John Frusciante was able to convince Kaenzig through a telephone to reveal some of the details. Kaenzig testified that Clonaid left him ignorant of cloning project and that it was not even a corporation. Next Tuesday, the judge summoned Kaenzig and Brigitte Boisselier to a Florida court on January 29, 2003 and warned the two that they would be condemned if they did not show.[16] According to sealed court documents received by the Boston Globe, Clonaid had two employees but no address or board of directors.[18]

In June 2, 2003, CBS News reported that Clonaid™ was not a company. Boisselier revealed that in a strict sense, Clonaid™ was just the product name, even though the website[19] touts it as the company name. According to Boisselier, Mark and Tracy Hunt, who were seeking clone their dead son, invested $500,000 in the former Clonaid lab in West Virginia and its equipment, which the Food and Drug Administration shut down. The Clonaid CEO proposed a cloning lab on Brazilian island for creating the next generation of clone babies.[20] Four months later, Clonaid said that five baby clones were born between 26 December 2002 and February 4, 2003 which had developed normally.[21]

On the following February, Clonaid claimed that a sixth clone baby was born in Australia.[22] Additionally, it claimed to have produced human embryos in South Korea. The small number of companies that have access to cloning technology has resulted skepticism by cloning experts in Korea, who accused Clonaid of defaming the now debunked stem cell work of Doctor Hwang Woo-suk.[23] By March, Clonaid claimed that eight extra baby clones had been brought to term for a total of thirteen baby clones.[24] In June, Florida attorney Bernard Siegel decided to meet with United Nations delegates and organized Nobel laureates to promote his cause to ban reproductive human cloning.[25] By Novemeber 19, the United Nations decided it could not make a united agreement on the extent of the human cloning ban, so it began to aim for a non-binding declaration instead.[26]

RMX 2010

What is verifiable at least is the existence of the RMX 2010, the latest embryonic cell fusion device developed by Clonaid itself and available for purchase according to the Clonaid website.

Clonaid, a human cloning firm, has established an affiliate company in Korea, participants at the International Bio Expo in Japan said Thursday. Participants and foreign media who attended the first biotechnology exposition in Tokyo, said that Clonaid's vice president Thomas Kaenzig claimed that BioFusion Tech Inc., a South Korean company owned by Clonaid, had developed an "embryonic cell fusion system or RMX2010." The sources in Japan said that the RMX2010 allegedly creates a stable electronic pulse required to develop human embryos to the blastocyst stage. The blastocyst stage is the state an embryo reaches five or six days after it has been fertilized, which is a critical step to instigate the cloning procedure. They also said that Kaenzig believes human cloning will become "commonplace" within ten years, though he failed to comment on any advances the company has made toward actually cloning a human being. Related to this, an official at BioFusion Tech Inc. confirmed that the company was set up two months ago as a wholly owned subsidiary of Clonaid and that there were currently three Korean technicians and six foreign employees working at the company. The BioFusion employee also said that about 10 Koreans have asked for cloning services, which according to the company Web site (www.clonaid.com) can cost around $200,000.[27]

— Korea Herald

CNN Money has listed the RMX 2010 as the fourth "Dumbest Moment in Business 2003", stating "Clonaid sells the RMX 2010, a $9,220 contraption that ... well, nobody's quite sure what it does. To help clarify the matter, Clonaid lends one to a British science museum--under strict orders not to open it to find out what's inside."[28]

Summary of skepticism

Scientists interviewed about the announcement averred skepticism regarding both the authenticity and the ethics of Clonaid's procedures. These included Lord Robert Winston[29], head of the IVF research team at London's Hammersmith Hospital, and Tanja Dominko[30] of the Oregon Regional Primate Center's monkey cloning project. Scientists with experience in animal cloning have encountered low rates of success per implantation, where cloned fetuses are often malformed and dead before birth. Regardless, people continue to be surprised that Clonaid appears to have overcome those problems; either Clonaid has been extremely lucky in discovering a superior method of cloning, or the company is making false claims.[17]

Clonaid charges up to $200,000 for its "cloning" services.[6] Clonaid has not shown verifiable evidence of any human cloning, despite claims that they would do this within days of their initial announcement. They claim that the parents of the first cloned child had second thoughts about submitting their child to scientific tests, following the U.S court order in January 2003.[16]

References

  1. ^ RMX2010 ‘Embryonic Cell Fusion Machine’, 2002., Science and Society Picture Library. Retrieved 20 October 2006.
  2. ^ Cohen, Philip, Cult's bizarre vision rekindles cloning debate, New Scientist. 31 May 1997. Retrieved 9 September 2007.
  3. ^ SWISS GROUP LAUNCHES FIRM TO MARKET HUMAN CLONING, San Jose Mercury News. 9 June 1997. Retrieved 9 September 2007. (highlight)
  4. ^ Is cloning Spot the next step towards cloning human being? Clonaid betting on it, Transplant News. 15 June 1998. Retrieved 9 September 2007. (highlight)
  5. ^ From little seeds…, New Scientist. 19 December 1998. Retrieved 9 September 2007.
  6. ^ a b c Weiss, Rick, Human Cloning's 'Numbers Game', Washington Post. 10 October 2000. Retrieved 9 September 2007.
  7. ^ Pro-cloning group claims to have embryos, CNN. 28 November 2001. Retrieved 9 September 2007.
  8. ^ Clonaid Claims It Has Cloned a Baby Girl, CNN. 27 December 2002. Retrieved 9 September 2007.
  9. ^ Young, Emma, First cloned baby "born on 26 December", MacNeil/Lehrer Productions. 27 December 2002. Retrieved 12 September 2007.
  10. ^ Clonaid Claims of Human Clone Scoffed At By Most Scientist, CNN International. 28 December 2002. Retrieved 9 September 2007.
  11. ^ Where is the Clone?, CNN. 9 September 2007.
  12. ^ a b c d e CNN.com - Clonaid: Baby 'clone' returns home - Jan. 1, 2003, CNN. 1 January 2003. Retrieved 9 September 2007.
  13. ^ Wired News: Clonaid Baby: A Clone or a Fake?, Wired News. 30 December 2002. Retrieved 9 September 2007.
  14. ^ Dutch lesbian 'has clone baby 2', Cable News Network. January 4 2007. Retrieved 10 February 2007.
  15. ^ Reporter caught in the wreckage of Clonaid story, USA Today. 7 January 2003. Retrieved 9 September 2007.
  16. ^ a b c Clonaid exec expected in court Wednesday, CNN. 28 January 2003. Retrieved 9 September 2007.
  17. ^ a b Clonaid says it's cloned first boy, CNN. 23 January 2003. Retrieved 9 September 2007.
  18. ^ Little behind Clonaid, files reveal, Milwaukee Journal Sentinel. 27 April 2003. Retrieved 9 September 2007.
  19. ^ The first human cloning company, Clonaid.com. Retrieved 10 September 2007.
  20. ^ Clonaid Nothing But Double Talk?, CBS News. 2 June 2003. Retrieved 9 September 2007.
  21. ^ 5 Babies Update, Clonaid.com. 15 October 2003. Retrieved 3 February 2007.
  22. ^ Sixth Cloned Baby Born Down-Under !, Clonaid.com. 9 February 2004. Retrieved 3 February 2007.
  23. ^ Clonaid Claims Embryos Needed for Human Cloning Produced in Korea, Chosun Ilbo. 24 February 2004. Retrieved 9 September 2007.
  24. ^ Alive and Well, Clonaid.com. 28 March 2004. Retrieved 3 February 2007.
  25. ^ Clone Newcomer Bends U.N.'s Ear, Wired News. Retrieved 11 September 2007.
  26. ^ U.N. Deadlocks on Cloning Ban, Wired News. 19 November 2004. Retrieved 11 September 2007.
  27. ^ Human cloning firm sets up affiliate in Korea, Korea Herald. 13 July 2002. Retrieved 19 July 2002.
  28. ^ The 101 Dumbest Moments In Business 2003 EDITION, CNN Money. 1 April 2003. Retrieved 10 March 2007.
  29. ^ Todd, Stephanie, Scientists scoff at cloned baby claim, Scotsman.com. Retrieved 10 February 2007.
  30. ^ Cloning news received with widespread skepticism, India Times. Retrieved 10 February 2007.

Further reading

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