Talk:Sulbutiamine

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Pharmacology B‑class Mid‑importance

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B	This article has been rated as B-class on Wikipedia's content assessment scale.
Mid	This article has been rated as Mid-importance on the project's importance scale.

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Sulbutiamine structure

Can someone that understands this better look at the 'mechanisms of action' section and fix the wording of this sentence?:

"Sulbutiamine is a thiamine derivative which has two different properties in comparison with vitamin B1 as a result of structural modification of free thiamine, namely opening of the thiazole ring, esterification of the alcohol groups and dimerization, with formation of a disulfide bridge." 209.63.116.205 (talk) 16:51, 2 October 2008 (UTC)[reply]

I completely reworded that sentence and moved it to the article opening where it makes more sense. The structural characteristics of sulbutiamine should not be included in the "Mechanism of action" section unless a structure-activity relationship (SAR) is being discussed. Firewall62 (talk) 04:59, 23 December 2008 (UTC)[reply]

I just revised the article again and removed the wordy discussion about the structural characteristics of sulbutiamine. Those characteristics are obvious when comparing the structures of sulbutiamine and thiamine. Pointing them out isn't necessary. In my opinion, the article should focus more on the biochemistry and clinical pharmacology of sulbutiamine--information that can't be obtained simply by looking at the structure. Firewall62 (talk) 20:09, 30 March 2009 (UTC)[reply]

Article development and assessment change

Over the past week, I have made numerous content additions and improvements to the article. At this point, practically every published source on sulbutiamine has been incorporated into the article and cited. Compared to other drugs, there is not a lot of information on sulbutiamine, and the length of the article will invariably be limited by the number of reliable sources. However, I believe that the article is currently B quality on the assessment scale, and I would like to see it reach GA quality in the future. Firewall62 (talk) 19:39, 6 April 2009 (UTC)[reply]