Talk:Nitric oxide

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
???	This article has not yet received a rating on Wikipedia's content assessment scale.
???	This article has not yet received a rating on the project's importance scale.

Template:Cell Signaling Project

How is it ?

The opening paragraph talks about NO being toxic but, down in the biological effects section, it is described as a muscle relaxant, vaso-dialator, etc.

I'm not clear what the "toxic" part is. Is NO more or less toxic than, say, Valium? I don't think "toxic" is used appropriately, here; should probably be replaced with "undesirable."

Wrong link to the Hazardous Chemical Database

The link in the article pointed to nitrogen selenide. R6144 11:52, 21 August 2005 (UTC)[reply]

structure

The structure,DUde thats not right as in whether it's linear, and etc, dipolee moment, polarity, or whatnot... should be added

Physical properties

What are the physical properties of nitric oxide? Color? Smell? See Nitrogen dioxide for an example. Twilight Realm 20:30, 12 October 2005 (UTC)[reply]

Name

I thought the suffixes -ous and -ic weren't used anymore. Instead of nitrogen monoxide redirecting here, shouldn't this article redirect there? I have the same complaint with nitrous oxide. Twilight Realm 20:30, 12 October 2005 (UTC)[reply]

It's me again. Actually, I just checked the talk page for nitrous oxide, and they said the common name should be used. So, as long as nitric oxide is the common name, I guess that's ok. But first I'd like some confirmation that this is the common name. Twilight Realm 20:30, 12 October 2005 (UTC)[reply]

Yet another edit. Go here to see my proposal on this topic. Twilight Realm 21:05, 12 October 2005 (UTC)[reply]

Environmental: While the article states that NO and NO2 contribute to the destruction of the ozone layer, this misses the important contribution of NO to ground level ozone production.

Bio-part of this article should be relocated?

A lot of nice bio-NO content in the present article, but it may be redundant with or more suitable for Endothelium-derived relaxing factor and signal transduction. IMHO.--Smokefoot 02:26, 28 August 2006 (UTC)[reply]

Chembox

I'm putting the old chembox here while I graft its info onto the new chembox.

Ben 20:13, 16 October 2006 (UTC)[reply]

**Properties**
General
Name	Nitrogen monoxide
File:Nitricoxide.png
Chemical formula	N O
Appearance	Colorless gas
Physical
Formula weight	30.0 amu
Melting point	109 K (-164 °C)
Boiling point	121 K (-152 °C)
Density	1.3 ×10³ kg/m³ (liquid)
Solubility	0.0056 g in 100g water
Thermochemistry
Δ_fH⁰_gas	90 kJ/mol
Δ_fH⁰_liquid	87.7 kJ/mol
S⁰_{gas, 1 bar}	211 J/mol·K
Safety
Ingestion	Used for medicinal purposes but has side effects and dangerous in overdose
Inhalation	Dangerous, may be fatal.
Skin	Irritant.
Eyes	May cause irritation
More info	Hazardous Chemical Database
SI units were used where possible. Unless otherwise stated, standard conditions were used. Disclaimer and references

Bonding

How does the oxygen bond to the nitrogen? I´ve learned the oxygen can only have two covalent bonds, and the nitrogen, three. If two electrons from each are in the bond, the nitrogen doesn´t have its octet complete. What happens, then? A.Z. 14:51, 2 November 2006 (UTC)[reply]

That's why it's considered a free radical. It has one electron which is usually shared along with another molecule's electron to form it's third bond, but instead there is no third bond and it is deemed a free radical. It doesn't like to be this way, that is why it is so reactive. You can see this in the structure you included with the single electron on top. 149.169.51.9 22:43, 19 December 2006 (UTC) Andrea[reply]

Minoxidil works through ATP-sensitive potassium channels

Minoxidil apparently works directly on ATP-sensitive potassium channels without stimulating cGMP or PKG. The Potassium hypothesis for hair growth has been supported by numerous agents that influence potassium flux altering hair growth. It appears to be direct on the dermal papillae and potassium channels, and not increased blood flow or PKG phosporylation cell signalling events. As far as NO and the hair follicle it is inducible by androgens and is present in follicle melanocytes (role in greying maybe) but I don't think it is exactly clear what role it plays (maybe associated with hair loss). I don't think the statements are accurate and upto date or appropriate for the topic of NO. Minoxidil maybe contains the molecular structure of NO but there is no proof that is how it effects hair growth. GetAgrippa 05:06, 4 February 2007 (UTC)[reply]

This sort of reminds me of some antidepressants as they were designed to modulate neutransmitter reuptake, etc. , yet the real function may have to do with neurogenesis in the hippocampus. Anyways, although minoxidil contains the NO structure the evidence doesn't support the effects on hair growth are NO mediated. GetAgrippa 03:22, 5 February 2007 (UTC)[reply]

N-O bond length

Bond length is given as 115 ppm. Anyone knows the source of this info? Preferably a scientfic paper. Thanks. -RTyg 131.130.30.233 14:35, 17 April 2007 (UTC)[reply]

NO-Xplode Redirect

NO-Xplode is a nutritional supplement, why does it redirect to Nitric Oxide? The page does not even mention the supplement. —The preceding unsigned comment was added by DaMenace123 (talk • contribs) 16:07, 16 May 2007 (UTC).[reply]

Vasodilation involves an increase in blood flow, the article states that dialtion induces a decrease in blood-flow, which is incorrect. Dilation does however create a decrease in blood pressure.

The entire Nutraceutical section needs rework. First off GNC is not the sole purveyor of NO "supplements", as a matter of fact the bigger name is Body Fortress. Of course I am too lazy to rewrite appropriately. In addition I added some citation requests. Thank you, -Anon. —Preceding unsigned comment added by 71.237.18.204 (talk) 06:40, 14 July 2009 (UTC)[reply]

Older industrial process

In an older process, NO is produced by an eletric arc. This method is well studed and used in the production of nitic acid before the Oswald process, and is caled Birkeland-Eyde process. —Preceding unsigned comment added by 189.42.228.115 (talk) 06:31, 15 February 2009 (UTC)[reply]

Nutraceutical marketing

I have removed this following section, as it seems to be a couple of editors' contributions in disagreement, and unless it is tidied up it really doesn't add to the article. Cheers, Freestyle-69 (talk) 05:16, 12 August 2009 (UTC)[reply]

GNC markets the following: Increases Power Output at the Onset of Fatigue by 20%** Delays the Onset of Neuromuscular Fatigue During Exercise** Micronized Arginine Amplifies Nitric Oxide Effects* from here: http://www.gnc.com/product/index.jsp?productId=3535343 They do not claim dramatic muscle growth. The powder form, N.O. Loaded, claims "Volumizes Muscle Cells & Improves Strength* Micronized Arginine for Fast Absorption Generates Increase in Muscle Power* Triggers Physical & Mental Intensity*" from here http://www.gnc.com/product/index.jsp?productId=3523713 Again, they do not claim dramatic muscle growth with this product. GNC has begun to sell an oral "nitric oxide" product targeted for bodybuilders, with the claim that it dramatically increases muscle growth. The claim is grounded in an understanding of NO as being a vasodilator, and when taken prior to and after workouts, it enables muscles to receive more blood and therefore, more oxygen and nutrients. This is critical to maximal muscle exertion during training and recovery afterward. However, there are currently no valid studies supporting the hypothesis that orally ingested NO actually will cause vasodilation; additionally, while users of some supplements have claimed to experience results^{[citation needed]}, these results are generally attributable to ingredients besides NO itself (proteins, creatine etc).^{[citation needed]}

Importance

How do we get the importance of this page rated? It desperately needs this as this is a critical biological mediator and is key to regulating blood pressure and the prevention of atherosclerosis. Indeed, the importance of NO was highlighted in 1998 when Robert F Furchgott, Louis J Ignarro and Ferid Murad were awarded the Nobel Prize for Physiology or Medicine for work that led to the discovery of NO as a biological mediator. NO even has it's own peer-reviewed journal. JustAnotherKinase (talk) 21:22, 5 October 2009 (UTC)[reply]

Hello and welcome to Wikipedia. This being a wiki, you can WP:Be bold, and rate it yourself. Go to the top of this talk, choose the project(s) that interest you, follow the links to their project page and look to see what they might say about their criteria for importance, and then come back here and edit the template to rate it yourself. By the way, these ratings are really only for internal use by their respective projects, and have little or no effect on how the general reading public sees the pages. --Tryptofish (talk) 22:15, 5 October 2009 (UTC)[reply]

Thanks, Have added importance JustAnotherKinase (talk) 22:02, 18 October 2009 (UTC).[reply]