Talk:Antipsychotic

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Neuroleptic vs. antipsychotic

"also known as neuroleptic even though not all antipsychotics have neuroleptic effect". Then what is a neuroleptic/the neuroleptic effect; neuroleptic redirects to antipsychotic, implying they (neuroleptic and antipsychotic) are one and the same, which contradicts the quoted sentence.ZFT (talk) 01:59, 25 September 2013 (UTC)[reply]

The term "neuroleptic" was introduced in a 1955 paper by Delay and Deniker, PMID 14392209. Unfortunately the text is not available to me, but as far as I can tell they defined a neuroleptic drug as one that induces Parkinsonian symptoms in high doses -- which basically means a drug that antagonizes dopamine transmission. Looie496 (talk) 02:49, 25 September 2013 (UTC)[reply]

Per this they are used synonomously [1] Will correct. Doc James (talk · contribs · email) (if I write on your page reply on mine) 12:36, 25 September 2013 (UTC)[reply]

Permanent Side Effects of Antipsychotic

I suggest the inclussion of more information about the permanent or semi-permanent side effects of the antipsychotic drugs. For example, while most side effects of antipsychotic drugs resolve quickly after discontinuation, several side effects are permanent or semi-permanent, such as tardive akathisia (in 98% irriversible), tardive dysckinesia, tardive dystonia, tardive dysphrenia, tardive psychosis, cataracts, glaucoma, side effects on the heart such as QT interval prolongation which leads to torsades des pointes (potentially fatal), etc. Many side effects are fatal: eg. stroke, neuroleptic malignant syndrome (may kill within 24 hrs if untreated), etc.

In the list of side effects, only very few common side effects are listed. The probability of some of them happening is greater than 1%, yes, but this is misleading, as many of them, for example insomnia, can happen with a probability of up to 40%. So I would recommend to change it to read "a probability of more than 1% up to 50%"

I would also recommend including the following: "The probability of side effects, ranging from less than 1% to 50%, is tipically obtained from drug trials of a few thaousand people for a few months. Since each person has different neurochemistry and genetics, the probability of side effects ocurring on one particular person is unpredictable, and it could happen at any time" — Preceding unsigned comment added by 190.52.139.38 (talk) 15:26, 6 October 2013 (UTC)[reply]

Hi 190.52.139.38 and thank you for your comments. Do you have good sources for your statements? Before adding any of your suggestions, please make sure that you have sources that are good enough according to WP:MEDRS. With friendly regards, Lova Falk talk 08:17, 20 October 2013 (UTC)[reply]

There are several references on the subject. To name a few: Metabolic syndrome: [2], Prolonged neurological sequelae: [3]; Tardive dyskinesia: [4]; Tardive akhatisia: [5]; Tardive dystonia: [6]; Tardive dysmentia: [7]; Potentially permanent effects on the heart: [8]; Neuroleptic malignant syndrome: [9]; Cerebrovascular adverse events (stroke): [10] 190.23.90.121 (talk) 09:37, 5 November 2013 (UTC)[reply]

Schizophrenia

This section is biased. It cherry-picks sources and reads like a sale pitch against antipsychotics. The section should be rewritten to include actual medical use of antipsychotics in schizophrenia and its existing content should be moved to the "Controversy" section. Jm292 (talk) 02:59, 16 November 2013 (UTC)[reply]

It is based on systematic reviews and meta analysis from the Cochrane collaboration. The evidence for antipsychotic use is poor. Which incredible seeing that they are so extensively used and the condition is relatively common. Doc James (talk · contribs · email) (if I write on your page reply on mine) 09:08, 17 November 2013 (UTC)[reply]

5HT2A

The section on 5HT2A claimed two things that are not substantiated. One, it claimed that antipsychotics antagonize the receptor, instead of partially agonizing it, which is an important distinction, in particular with this receptor. It also claimed that agonism of this receptor is associated with psychosis. This is not well-substantiated, as antipsychotics do agonize the drug, not antagonize it, and also because psychedelic drug use, which also agonize to antagonize this receptor, are associated with lower psychosis risk.

I added reviews claiming that different alleles are associated with psychosis, and also that higher receptor concentrations in certain areas associate with psychosis. I also added brief mention to SSRIs and psychedelic drugs. — Preceding unsigned comment added by 205.208.122.240 (talk) 22:14, 16 December 2013 (UTC)[reply]

Ok I fixed what you messed up, atypical antipsychotics DO antagonize the 5HT2A receptor, not agonize, I believe that you are confusing the tendency of atypical antipsychotics to partially agonize the 5HT1A receptor with the 2A receptor. Psychedelic drugs agonize the 5HT2A receptor and have been shown to potentiate psychosis in schizophrenic patients.