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Revision as of 18:01, 13 February 2018 by Psanchez820(talk | contribs)(Added information about function and it's role in cancer)
Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. [9] This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.[10]
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Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K (December 2001). "A potential role for human cohesin in mitotic spindle aster assembly". The Journal of Biological Chemistry. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID11590136.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Lara-Pezzi E, Pezzi N, Prieto I, Barthelemy I, Carreiro C, Martínez A, Maldonado-Rodríguez A, López-Cabrera M, Barbero JL (February 2004). "Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3". The Journal of Biological Chemistry. 279 (8): 6553–9. doi:10.1074/jbc.M307663200. PMID14660624.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". Journal of Cell Science. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID15855230.