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STAG2

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STAG2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13
External IDsOMIM: 300826; MGI: 1098583; HomoloGene: 38206; GeneCards: STAG2; OMA:STAG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077712
NM_001290713
NM_021465
NM_001358225

RefSeq (protein)

NP_001071180
NP_001277642
NP_067440
NP_001345154

Location (UCSC)Chr X: 123.96 – 124.42 MbChr X: 41.24 – 41.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.[5][6]

Function

STAG2 is part of the cohesin complex, which is a structure that holds the sister chromatids together after DNA replication.[7] STAG2 has been shown to interact with STAG1.[8]

Role in Disease

Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. [9] This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101972Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025862Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  6. ^ "Entrez Gene: STAG2 stromal antigen 2".
  7. ^ Mehta, Gunjan D.; Kumar, Ravinder; Srivastava, Sanjeeva; Ghosh, Santanu Kumar (2013-08-02). "Cohesin: Functions beyond sister chromatid cohesion". FEBS Letters. 587 (15): 2299–2312. doi:10.1016/j.febslet.2013.06.035. ISSN 1873-3468.
  8. ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  9. ^ Cosmic. "STAG2 Gene - COSMIC". cancer.sanger.ac.uk. Retrieved 2018-02-13.
  10. ^ Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo; Wutz, Gordana; Hill, Victoria; Peters, Jan-Michael; Compton, Duane A.; Waldman, Todd (2016-02-12). "Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2". PLOS Genetics. 12 (2): e1005865. doi:10.1371/journal.pgen.1005865. ISSN 1553-7404.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading