STAG2

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STAG2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2
External IDs MGI: 1098583 HomoloGene: 38206 GeneCards: STAG2
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for STAG2
Genomic location for STAG2
Band Xq25 Start 123,960,212 bp[1]
End 124,422,664 bp[1]
RNA expression pattern
PBB GE STAG2 209023 s at fs.png

PBB GE STAG2 209022 at fs.png

PBB GE STAG2 207983 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042749
NM_001042750
NM_001042751
NM_001282418
NM_006603

NM_001077712
NM_001290713
NM_021465
NM_001358225

RefSeq (protein)

NP_001036214
NP_001036215
NP_001036216
NP_001269347
NP_006594

NP_001071180
NP_001277642
NP_067440
NP_001345154

Location (UCSC) Chr X: 123.96 – 124.42 Mb Chr X: 42.15 – 42.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.[5][6]

Function[edit]

STAG2 is part of the cohesin complex, which is a structure that holds the sister chromatids together after DNA replication.[7] STAG2 has been shown to interact with STAG1.[8]

Role in Disease[edit]

Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. [9] This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.[10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101972 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025862 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759. 
  6. ^ "Entrez Gene: STAG2 stromal antigen 2". 
  7. ^ Mehta, Gunjan D.; Kumar, Ravinder; Srivastava, Sanjeeva; Ghosh, Santanu Kumar (2013-08-02). "Cohesin: Functions beyond sister chromatid cohesion". FEBS Letters. 587 (15): 2299–2312. doi:10.1016/j.febslet.2013.06.035. ISSN 1873-3468. 
  8. ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443Freely accessible. PMID 11076961. 
  9. ^ Cosmic. "STAG2 Gene - COSMIC". cancer.sanger.ac.uk. Retrieved 2018-02-13. 
  10. ^ Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo; Wutz, Gordana; Hill, Victoria; Peters, Jan-Michael; Compton, Duane A.; Waldman, Todd (2016-02-12). "Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2". PLOS Genetics. 12 (2): e1005865. doi:10.1371/journal.pgen.1005865. ISSN 1553-7404. 

Further reading[edit]