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Breast biopsy

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Surgical Breast Biopsy
Surgeon doing a surgical breast biopsy
ICD-9-CM85.11-85.12

A breast biopsy is usually done after a suspicious lesion is discovered on either mammography or ultrasound in order to get tissue for pathological diagnosis.[1] Several methods for a breast biopsy now exist. The most appropriate method of biopsy for a patient depends upon a variety of factors, including the size, location, appearance and characteristics of the abnormality.[2] The different types of breast biopsies include fine needle aspiration (FNA), vacuum assisted biopsy, core needle biopsy, and surgical biopsy. Breast biopsies can be done under ultrasound, MRI or a stereotactic technique. [3][4][5][6] Vacuum assisted biopsies are typically done using stereotactic techniques when the suspicious lesion can only be seen on mammography. [4] On average, 5-10 biopsies of a suspicious breast lesion will lead to the diagnosis of one case of breast cancer. [7]

Indications

There are many reasons why your doctor may order a breast biopsy. Typical indications include:

  • A suspicious area of mammography or ultrasound
  • A suspicious palpable lump
  • Skin changes like crusting, scaling, or dimpling of the breast, which may signal an underlying breast cancer
  • Abnormal nipple discharge [7][8]

Fine needle aspiration

Main article: Fine-needle aspiration

Fine needle aspiration (FNA) is a percutaneous ("through the skin") procedure that uses a fine needle and a syringe to sample fluid from a breast cyst or remove clusters of cells from a solid mass. It is mainly used to differentiate between a cyst and a mass. If the aspirated contents are not cyst-like, then a tissue sample must be taken to better evaluate the mass. [6] Fine needle aspiration is one of the most commonly used initial diagnostic tools for suspicious lesions. The doctor will typically use a 22 or 27 gauge needle to aspirate out free fluid and cells. It can be done in an outpatient setting and is associated with minimal pain. However, in up to 30% of cases, pathological slides from fine needle aspiration of breast lesions may be inconclusive, necessitating the need for further testing.[9] FNA can be done to aspirate the contents of a cyst, which may relieve any pain that the cyst caused, or can be used to aspirate a suspicious lesion in conjunction with cytology. If aspirating the contents of a cyst, the aspirate is usually not sent for cytology unless it is bloody. If the cyst is not palpable, it may be located using ultrasound, MRI, or stereotactic mammography. Recovery time from an outpatient FNA is minimal. [10]

Core needle biopsy

here is info for core needle

Vacuum assisted breast biopsy

Vacuum assisted breast biopsy (VABB) is a more recent version of core needle biopsy using a vacuum technique to assist the collection of the tissue sample. Similarly to core needle biopsy the needle has a lateral ("from the side") opening and can be rotated allowing multiple samples to be collected through a single skin incision. This method has become more popular than FNA, CNB, and surgical biopsies due to the benefits of low invasiveness with high tissue sample. Greater tissue helps reduce sampling error since breast lesions are often heterogeneous (cancer cells are spread unevenly) and therefore cancer can be missed if not enough tissue is taken.[11] The vacuum assisted biopsy category also includes automated rotational core devices.[12]

Direct and frontal biopsy

Recent innovations in tissue acquisition for the human breast have led to the development of unique direct frontal systems. Efficacy is considered optimal if the diagnosis by transcutaneous biopsy is identical to the surgical specimen in case of malignancy or in line with clinical follow-up when benign.[citation needed]

The direct and frontal biopsy systems can even be considered relatively painless. The quality of the sample is sufficient for research on molecular biology.[13][14][15]

Adverse Effects

Adverse effects of breast biopsies tend to vary depending on what type of biopsy is performed. The more invasive, such as surgery, tend to have more severe types of adverse incidents, whereas less invasive such as FNA or CNB tend to have less severe. For vacuum assisted biopsies, some complications of the procedure can include bleeding, post operative pain, and hematoma formation. However, most can be avoided with proper application of pressure and rest.[11] Some examples of adverse effects of core needle biopsies can include rare biopsy risks like infection, abscess formation, fistula formation, migration of any markers placed in the breast, and potential seeding of the tumor. [1] [16] Another potential adverse effect occurs when taking a biopsy of an area of microcalcification. If the entire area of microcalcification is removed, it is then very difficult to find the suspicious area in the future for treatment. [16] Bleeding into the site of the suspicious lesion caused by the biopsy procedure can appear to look like a complex cyst on ultrasound, which could lead to additional unnecessary management. The false negative rate of the results of a breast biopsy is approximately 1%. [10]

References

  1. ^ a b Jain A, Khalid M, Qureshi MM, Georgian-Smith D, Kaplan JA, Buch K, Grinstaff MW, Hirsch AE, Hines NL, Anderson SW, Gallagher KM, Bates DD, Bloch BN (November 2017). "Stereotactic core needle breast biopsy marker migration: An analysis of factors contributing to immediate marker migration". European Radiology. 27 (11): 4797–4803. doi:10.1007/s00330-017-4851-7. PMID 28526892.
  2. ^ "Complications associated with ultrasound-guided breast core needle biopsy (CNB)". Zenodo. 2016-05-03. doi:10.5281/zenodo.1038518.
  3. ^ Wang M, He X, Chang Y, Sun G, Thabane L (February 2017). "A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: A systematic review and meta-analysis". Breast. 31: 157–166. doi:10.1016/j.breast.2016.11.009. PMID 27866091.
  4. ^ a b Esen G, Tutar B, Uras C, Calay Z, İnce Ü, Tutar O (July 2016). "Vacuum-assisted stereotactic breast biopsy in the diagnosis and management of suspicious microcalcifications". Diagnostic and Interventional Radiology. 22 (4): 326–33. doi:10.5152/dir.2015.14522. PMC 4956017. PMID 27306660.
  5. ^ Fernández-García P, Marco-Doménech SF, Lizán-Tudela L, Ibáñez-Gual MV, Navarro-Ballester A, Casanovas-Feliu E (January 2017). "The cost effectiveness of vacuum-assisted versus core-needle versus surgical biopsy of breast lesions". Radiologia. 59 (1): 40–46. doi:10.1016/j.rx.2016.09.006. PMID 27865561.
  6. ^ a b Dinas K, Pratilas GC, Nasioutziki M, Vavoulidis E, Makris V, Loufopoulos PD, Kalder M (September 2018). "Clinical Significance of Fine Needle Aspiration in Managing Patients with Breast Lesions". Folia Medica. 60 (3): 364–372. doi:10.2478/folmed-2018-0002. PMID 30355841.
  7. ^ a b Jameson, J. Harrison's Principles of Internal Medicine. Breast Cancer: McGraw-Hill.
  8. ^ Gantenbein H, Spieler P (November 1986). "[Fine-needle aspiration biopsy of the breast. Frequency, indication and accuracy, studied on material from the Cytological Laboratory of the Pathology Institute, St. Gallen Canton Hospital, 1981-1984]". Schweizerische Medizinische Wochenschrift. 116 (44): 1513–8. PMID 3024311.
  9. ^ Joudeh AA, Shareef SQ, Al-Abbadi MA (2016). "Fine-Needle Aspiration Followed by Core-Needle Biopsy in the Same Setting: Modifying Our Approach". Acta Cytologica. 60 (1): 1–13. doi:10.1159/000444386. PMID 26963594.
  10. ^ a b YM, Michael (2011). Basic Radiology. Chapter 5: McGraw-Hill.{{cite book}}: CS1 maint: location (link)
  11. ^ a b Park, Hai-Lin; Hong, Jisun (2014-5). "Vacuum-assisted breast biopsy for breast cancer". Gland Surgery. 3 (2): 120–127. doi:10.3978/j.issn.2227-684X.2014.02.03. ISSN 2227-684X. PMC 4115763. PMID 25083505. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
  12. ^ "ADVANCE for Health Information Professionals - Editorial". advanceweb.com.
  13. ^ Cornelis A, Verjans M, Van den Bosch T, Wouters K, Van Robaeys J, Janssens JP (August 2009). "Efficacy and safety of direct and frontal macrobiopsies in breast cancer". European Journal of Cancer Prevention. 18 (4): 280–4. doi:10.1097/CEJ.0b013e328329d885. PMID 19352188.
  14. ^ High-Precision Direct and Frontal Breast Biopsy to Assure Adequate Surgical Margin Interpretation; Jaak Janssens, MD, PhD; Ruediger Schulz-Wendtland, MD, PhD; Luc Rotenberg, MD; John-Paul Bogers, MD, PhD
  15. ^ Goss PE, Ingle JN, Alés-Martínez JE, Cheung AM, Chlebowski RT, Wactawski-Wende J, et al. (June 2011). "Exemestane for breast-cancer prevention in postmenopausal women". The New England Journal of Medicine. 364 (25): 2381–91. doi:10.1056/NEJMoa1103507. PMID 21639806.
  16. ^ a b Nathan C, Rolland Y (2002). "Pharmacological treatments that affect CNS activity: serotonin". Annals of the New York Academy of Sciences. 499 (Suppl 1): 277–96. doi:10.1186/bcr513. PMC 3300487.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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