Talk:Ageing

This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 July 2019 and 23 August 2019. Further details are available on the course page. Student editor(s): Tnguyen26, Allydiiorio (article contribs).

Guardian article: strategies for life extension

The Guardian (London, 6 Oct 2018) summarises current research strategies for living longer, focussing especially on removal of senescent cells from the body that are believed to cause inflammation. Other strategies mentioned are metformin, rapamycin, NAD-plus, cellular rejuvenation back to stem cell stage, and of course lifestyle. Can a scientist please find reputable review articles for these subjects and work them into the article where necessary (some of the points are already mentioned)? Thanks. 86.180.158.120 (talk) 17:35, 15 November 2018 (UTC)

References

Section “Physical basis” into the article “Ageing”

Dear Colleagues, I would like to ask you to discuss the possibility of introducing the section “Physical basis”

Dear Gladderstock, I am not persuaded by the merits of your suggested thermodynamics paragraph below ("Physical basis"). The thermodynamics theory fails to explain why some organisms age (animals, fungi), while others do not (bacteria, perennial plants). Indeed the thermodynamics theory, as presented, does not even seem to be aware of this basic biological distinction. But perhaps I am doing the authors an injustice - please defend them if you can.86.180.157.149 (talk) 21:23, 14 December 2018 (UTC)

For example -

Physical basis

Thermodynamics of aging of living beings (or the thermodynamic theory of aging) studies the phenomenon of aging of objects of the living world from the standpoint of hierarchical thermodynamics . The thermodynamic theory of aging is part of a general theory of the origin of life, its evolution and aging. The foundations of the theory were laid by G. P. Gladyshev on the basis of the extended theory of J. W. Gibbs, applicable to supramolecular natural systems close to an equilibrium state. The theory describes aging from the standpoint of ontogenesis, which, in terms of hierarchical thermodynamics, repeats phylogenesis . Within the framework of applicability, the theory, like classical thermodynamics, cannot be refuted. Aging is accompanied by a desire to minimize the Gibbs specific free energy of formation of the supramolecular structures of the body, due to changes in its chemical composition and structure . These changes, due to the spontaneous guiding action of the second law, occur against the background of involuntary (non-spontaneous) processes initiated by the environment . The aging of the body proceeds in the same way as the aging of a wick of a burning candle or a sorbent of a non-stationary chromatographic column. In this connection, the thermodynamic theory of aging is sometimes called the chromatographic theory of aging . Thermodynamics of aging contributed to the emergence of new branches of science, such as thermodynamic dietetics. The use of the Gibbs-Helmholtz equation and its analogue made it possible on a quantitative basis to make predictions concerning anti-aging diets and indicators determining the gerontological value of food products and cosmetics. Thus, in the monographs and articles of the author of the thermodynamic theory, the quantitatively substantiated statements are presented: “Diets that include thermodynamically evolutionarily young products of plant and animal origin contribute to longevity and improve the quality of human life. The exponent of evolutionary youth of a natural food product is determined by its chemical composition and supramolecular structure. The chemical composition and supramolecular structure of the product, in turn, depend on its ontogenetic and phylogenetic ages, as well as the habitat of the organism - the source of this product. An important quantitative characteristic of the ‘gerontological utility of a natural food product is the value of the Gibbs specific function of the formation of its supramolecular structure.” In accordance with theory, the food of cold regions has an increased value . Gladderstock (talk) 14:30, 11 December 2018 (UTC)

UCSF Foundations 2 , 2019 , Group 6b Goals

The Group Goals: is to 1) Verify the validity of sources . 2) Expand on the relevance of certain sections. 3) Revise paragraphs for clarity. Tnguyen26 (talk) 21:09, 30 July 2019 (UTC)