Y linkage: Difference between revisions

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{{refimprove|date=April 2009}}
{{refimprove|date=April 2009}}
In mammals, '''Y-linkage''' refers to when a phenotypic trait is determined by an allele (or gene) on the [[Y chromosome]]. It is also known as holandric inheritance.
In mammals, '''Y-linkage''', also known as '''holandric inheritance,''' is the determination of a [[phenotypic trait]] by an [[allele]] (or gene) on the [[Y chromosome]].


The Y-chromosome is small and does not contain many genes, therefore few traits are Y-linked, and Y-linked diseases are rare. Because the only humans which have a Y chromosome are males, the genes are simply passed from father to son, with no interchromosomal [[genetic recombination]].
Because the Y-chromosome is small and does not contain many genes, few traits are Y-linked, and Y-linked diseases are rare. Since the only humans who have a Y chromosome are males, Y-linked traits are passed only from father to son, with no interchromosomal [[genetic recombination]].


Chromosome Y deletions are a frequent genetic cause of [[male infertility]]. Another example in humans of a y-linked trait was thought to be hairy ears (it may also be sex-limited).<ref>[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=425500 Online Mendelian Inheritance of Man], HAIRY EARS, Y-LINKED, although see [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139500 HAIRY EARS].</ref>
[[Y-Chromosome deletions]] are a frequent genetic cause of [[male infertility]]. Having hairy ears was once though to be a Y-linked trait in humans,<ref>[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=425500 Online Mendelian Inheritance of Man], HAIRY EARS, Y-LINKED, although see [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139500 HAIRY EARS].</ref>
However, this has been discredited.<ref>http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS0-4JVTBNK-1&_user=10&_coverDate=06%2F30%2F2006&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1759287863&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce69fbedf159884f9ec161c3477b26b7&searchtype=a</ref>
but that hypothesis has been discredited.<ref>http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS0-4JVTBNK-1&_user=10&_coverDate=06%2F30%2F2006&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1759287863&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce69fbedf159884f9ec161c3477b26b7&searchtype=a</ref>


==Genes contained on the Y chromosome==
==Genes known to be contained on the Y chromosome==
As of the year 2000, a number of genes were known to be Y-linked including:<ref>http://www.medterms.com/script/main/art.asp?articlekey=15745</ref>
As of the year 2000, a number of genes were known to be Y-linked, including:<ref>http://www.medterms.com/script/main/art.asp?articlekey=15745</ref>
*ASMTY (which stands for acetylserotonin methyltransferase),
*ASMTY (acetylserotonin methyltransferase),
*[[TSPY1|TSPY (testis-specific protein)]],
*[[TSPY1|TSPY (testis-specific protein)]],
*IL3RAY (interleukin-3 receptor),
*IL3RAY (interleukin-3 receptor),
*[[SRY|SRY (sex-determining region)]],
*[[SRY|SRY (sex-determining region)]],
*[[Testis determining factor|TDF (testis determining factor)]],
*[[Testis determining factor|TDF (testis determining factor)]],
*ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
*ZFY (zinc finger protein)
*PRKY (protein kinase, Y-linked),
*[[Amelogenin|AMGL (amelogenin)]],
*[[Amelogenin|AMGL (amelogenin)]],
*CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
*CSF2RY (granulocyte-macrophage, colony-stimulating factor receptor, alpha subunit on the Y chromosome),
*ANT3Y (adenine nucleotide translocator-3 on the Y),
*ANT3Y (adenine nucleotide translocator-3 on the Y),
*[[SOX21|SOX21(known to cause baldness)]],
*[[./SOX21|SOX21 (known to cause baldness)]],
*AZF2 (azoospermia factor 2),
*AZF2 (azoospermia factor 2),
*BPY2 (basic protein on the Y chromosome),
*BPY2 (basic protein on the Y chromosome),

Revision as of 16:56, 18 December 2012

In mammals, Y-linkage, also known as holandric inheritance, is the determination of a phenotypic trait by an allele (or gene) on the Y chromosome.

Because the Y-chromosome is small and does not contain many genes, few traits are Y-linked, and Y-linked diseases are rare. Since the only humans who have a Y chromosome are males, Y-linked traits are passed only from father to son, with no interchromosomal genetic recombination.

Y-Chromosome deletions are a frequent genetic cause of male infertility. Having hairy ears was once though to be a Y-linked trait in humans,[1] 

but that hypothesis has been discredited.[2]

Genes known to be contained on the Y chromosome

As of the year 2000, a number of genes were known to be Y-linked, including:[3]

See also

References

  1. ^ Online Mendelian Inheritance of Man, HAIRY EARS, Y-LINKED, although see HAIRY EARS.
  2. ^ http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS0-4JVTBNK-1&_user=10&_coverDate=06%2F30%2F2006&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1759287863&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce69fbedf159884f9ec161c3477b26b7&searchtype=a
  3. ^ http://www.medterms.com/script/main/art.asp?articlekey=15745

External links


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