2-aminoadipate transaminase

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2-aminoadipate transaminase
EC no.
CAS no.9033-00-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-aminoadipate transaminase (EC is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate + 2-oxoglutarate 2-oxoadipate + L-glutamate

Thus, the two substrates of this enzyme are L-2-aminoadipate and 2-oxoglutarate, whereas its two products are 2-oxoadipate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-2-aminoadipate:2-oxoglutarate aminotransferase. Other names in common use include alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, and glutamate-alpha-ketoadipate transaminase. This enzyme participates in lysine biosynthesis and lysine degradation. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DTV.


  • Matsuda M, Ogur M (1969). "Separation and specificity of the yeast glutamate-alpha-ketoadipate transaminase". J. Biol. Chem. 244 (12): 3352–8. PMID 5792664.